SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 8 LEU A  88
LEU A  29
ALA A  32
LYS A  33
 None
 0.69A 1e7cA-3a5vA:
undetectable		 1e7cA-3a5vA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 ILE A 277
ILE A 269
VAL A 274
ILE A  35
ILE A  49
 None
 1.05A 1oipA-3a5vA:
undetectable		 1oipA-3a5vA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 ILE A 277
ILE A 269
VAL A 274
ILE A  35
ILE A  49
 None
 1.08A 1r5lA-3a5vA:
undetectable		 1r5lA-3a5vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		3 / 3 GLY A 271
GLU A 243
ASN A  14
 None
 0.65A 1zq9A-3a5vA:
undetectable		 1zq9A-3a5vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 11 ILE A  28
ALA A  31
ALA A  32
LEU A  88
ILE A  76
 None
 0.85A 2aclE-3a5vA:
undetectable		 2aclE-3a5vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 8 LEU A 328
VAL A 217
VAL A 225
VAL A 307
 None
 0.88A 2bdmA-3a5vA:
undetectable		 2bdmA-3a5vA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 10 ASN A 130
ASP A 240
ARG A 185
ASP A  52
ALA A 211
 None
None
None
TRS  A 841 (-3.6A)
None
 1.40A 2ecpB-3a5vA:
2.1		 2ecpB-3a5vA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 5 ILE A  35
LEU A  40
ASP A 273
ALA A  31
 None
 1.00A 2opxA-3a5vA:
undetectable		 2opxA-3a5vA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		3 / 3 SER A 373
ASP A 342
ASP A 353
 None
 0.54A 2plwA-3a5vA:
undetectable		 2plwA-3a5vA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 4 LEU A 388
ASP A 296
VAL A 290
THR A 259
 None
1PG  A 851 (-4.3A)
None
None
 1.32A 3cyxB-3a5vA:
undetectable		 3cyxB-3a5vA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_2
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 6 THR A 278
ASN A 246
TYR A 258
TRP A 364
 None
 1.37A 3jzjA-3a5vA:
0.0		 3jzjA-3a5vA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
 None
 1.02A 3sudC-3a5vA:
undetectable		 3sudC-3a5vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
 None
 0.99A 3sueA-3a5vA:
undetectable		 3sueA-3a5vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
 None
 1.02A 3sufD-3a5vA:
undetectable		 3sufD-3a5vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 ASP A 189
ARG A 185
SER A 181
PHE A 176
ALA A  96
 None
 1.00A 3ua1A-3a5vA:
undetectable		 3ua1A-3a5vA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 ILE A  28
ALA A  31
ALA A  32
LEU A  88
ILE A  92
 None
 1.21A 3uvvB-3a5vA:
undetectable		 3uvvB-3a5vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 VAL A 274
SER A  37
SER A  38
TRP A  13
TYR A  19
 None
 1.29A 4amjA-3a5vA:
undetectable		 4amjA-3a5vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 VAL A 274
SER A  37
SER A  38
TRP A  13
TYR A  19
 None
 1.28A 4amjB-3a5vA:
undetectable		 4amjB-3a5vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 MET A 150
ILE A  49
ASP A  51
ARG A  59
ILE A  92
 None
None
TRS  A 841 (-3.3A)
None
None
 1.34A 4djfA-3a5vA:
10.4		 4djfA-3a5vA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 7 ASP A 129
ASP A  51
ASP A 238
ASN A  14
 TRS  A 841 (-4.0A)
TRS  A 841 (-3.3A)
None
None
 1.22A 4fevB-3a5vA:
undetectable		 4fevB-3a5vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 8 ASP A 129
ASP A  51
ASP A 238
ASN A  14
 TRS  A 841 (-4.0A)
TRS  A 841 (-3.3A)
None
None
 1.20A 4gkhD-3a5vA:
undetectable		 4gkhD-3a5vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 6 ASP A 129
ASP A  51
ASP A 238
ASN A  14
 TRS  A 841 (-4.0A)
TRS  A 841 (-3.3A)
None
None
 1.25A 4gkhJ-3a5vA:
undetectable		 4gkhJ-3a5vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 8 LEU A 270
LEU A 242
VAL A 244
ILE A 284
 None
 0.96A 4oj4A-3a5vA:
undetectable		 4oj4A-3a5vA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		3 / 3 ASP A 129
TYR A  93
TRP A 168
 TRS  A 841 (-4.0A)
TRS  A 841 (-4.2A)
None
 0.95A 4p7nA-3a5vA:
10.9		 4p7nA-3a5vA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 5 GLN A 136
LEU A 142
SER A 143
ASP A 189
 None
 1.26A 4qtuD-3a5vA:
undetectable		 4qtuD-3a5vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 PHE A 194
MET A 218
ILE A 221
ALA A 330
VAL A 290
 None
 1.33A 4qynA-3a5vA:
undetectable		 4qynA-3a5vA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		3 / 3 SER A 164
TYR A 125
ASP A 240
 None
 0.87A 4rp8C-3a5vA:
undetectable		 4rp8C-3a5vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 8 ILE A  76
ILE A  83
ILE A  28
GLU A  25
 None
 0.63A 5mvmA-3a5vA:
undetectable
5mvmB-3a5vA:
undetectable		 5mvmA-3a5vA:
15.11
5mvmB-3a5vA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 VAL A 293
ASP A 296
LEU A 313
ALA A 263
PRO A 301
 1PG  A 851 ( 4.5A)
1PG  A 851 (-4.3A)
None
None
None
 1.03A 5nd3B-3a5vA:
undetectable		 5nd3B-3a5vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 8 GLY A 188
TRP A 261
ASP A 238
ASP A 129
 None
None
None
TRS  A 841 (-4.0A)
 1.03A 5vlmB-3a5vA:
undetectable		 5vlmB-3a5vA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		4 / 5 ALA A 177
SER A 181
TYR A 163
TYR A 147
 None
 1.36A 5yodF-3a5vA:
1.1		 5yodF-3a5vA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 ILE A  28
ALA A  31
ALA A  32
LEU A  88
ILE A  76
 None
 0.91A 6a60D-3a5vA:
undetectable		 6a60D-3a5vA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 3a5v ALPHA-GALACTOSIDASE
(Umbelopsis
vinacea) 		5 / 12 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
 None
 1.04A 6c2mD-3a5vA:
undetectable		 6c2mD-3a5vA:
11.11