SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 10 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.42A 1fk9A-3a5wA:
undetectable		 1fk9A-3a5wA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 11 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.28A 1fkpA-3a5wA:
undetectable		 1fkpA-3a5wA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 10 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.50A 1h4oA-3a5wA:
16.3
1h4oB-3a5wA:
16.4		 1h4oA-3a5wA:
23.65
1h4oB-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.51A 1h4oB-3a5wA:
16.4		 1h4oB-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.53A 1h4oC-3a5wA:
16.3
1h4oD-3a5wA:
16.3		 1h4oC-3a5wA:
23.65
1h4oD-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.52A 1h4oD-3a5wA:
16.3		 1h4oD-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.50A 1h4oE-3a5wA:
16.4
1h4oF-3a5wA:
16.3		 1h4oE-3a5wA:
23.65
1h4oF-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_F_BEZF1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.52A 1h4oF-3a5wA:
16.3		 1h4oF-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.49A 1h4oG-3a5wA:
16.3		 1h4oG-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.51A 1h4oH-3a5wA:
16.4		 1h4oH-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.54A 1hd2A-3a5wA:
16.3		 1hd2A-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 11 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.30A 1jkhA-3a5wA:
undetectable
1jkhB-3a5wA:
undetectable		 1jkhA-3a5wA:
18.89
1jkhB-3a5wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 10 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.34A 1lw0A-3a5wA:
undetectable		 1lw0A-3a5wA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.51A 1oc3A-3a5wA:
16.3		 1oc3A-3a5wA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_B_BEZB201_0
(PEROXIREDOXIN 5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.53A 1oc3B-3a5wA:
15.9		 1oc3B-3a5wA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_A_CHCA202_1
(BILE ACID RECEPTOR)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 12 ALA A 233
SER A  56
PHE A  57
ILE A 154
TYR A 143
 None
 1.48A 1osvA-3a5wA:
undetectable		 1osvA-3a5wA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 ALA A 103
ASP A  77
GLY A  73
ILE A  72
 None
 0.84A 1t7iB-3a5wA:
undetectable		 1t7iB-3a5wA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 ALA A 103
ASP A  77
GLY A  73
ILE A  72
 None
 0.82A 1t7jB-3a5wA:
undetectable		 1t7jB-3a5wA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.28A 1vrtA-3a5wA:
undetectable		 1vrtA-3a5wA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 10 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.29A 2hndA-3a5wA:
undetectable		 2hndA-3a5wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 ILE A 154
ARG A 232
ARG A  59
PHE A  40
 None
 1.10A 2q6hA-3a5wA:
undetectable		 2q6hA-3a5wA:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.24A 2v2gA-3a5wA:
22.4
2v2gB-3a5wA:
22.4		 2v2gA-3a5wA:
33.20
2v2gB-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.22A 2v2gA-3a5wA:
22.4
2v2gB-3a5wA:
22.4		 2v2gA-3a5wA:
33.20
2v2gB-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.23A 2v2gC-3a5wA:
22.5
2v2gD-3a5wA:
22.4		 2v2gC-3a5wA:
33.20
2v2gD-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.22A 2v2gC-3a5wA:
22.5
2v2gD-3a5wA:
22.4		 2v2gC-3a5wA:
33.20
2v2gD-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 8 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.20A 2v32A-3a5wA:
22.4
2v32B-3a5wA:
22.3		 2v32A-3a5wA:
33.20
2v32B-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 8 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.23A 2v32A-3a5wA:
22.4
2v32B-3a5wA:
22.3		 2v32A-3a5wA:
33.20
2v32B-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.35A 2v32C-3a5wA:
22.5
2v32D-3a5wA:
23.3		 2v32C-3a5wA:
33.20
2v32D-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 8 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.22A 2v32C-3a5wA:
22.5
2v32D-3a5wA:
23.3		 2v32C-3a5wA:
33.20
2v32D-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.32A 2v41A-3a5wA:
22.3
2v41B-3a5wA:
22.4		 2v41A-3a5wA:
33.20
2v41B-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 9 PRO A  43
THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.32A 2v41A-3a5wA:
22.3
2v41B-3a5wA:
22.4		 2v41A-3a5wA:
33.20
2v41B-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.29A 2v41C-3a5wA:
23.1
2v41D-3a5wA:
23.6		 2v41C-3a5wA:
33.20
2v41D-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.35A 2v41C-3a5wA:
23.1
2v41D-3a5wA:
23.6		 2v41C-3a5wA:
33.20
2v41D-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.27A 2v41E-3a5wA:
22.4
2v41F-3a5wA:
22.5		 2v41E-3a5wA:
33.20
2v41F-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 7 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.25A 2v41E-3a5wA:
22.4
2v41F-3a5wA:
22.5		 2v41E-3a5wA:
33.20
2v41F-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 8 THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.28A 2v41G-3a5wA:
22.4
2v41H-3a5wA:
22.5		 2v41G-3a5wA:
33.20
2v41H-3a5wA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 8 PRO A  43
THR A  47
PRO A  48
VAL A  49
ARG A 126
 None
 0.27A 2v41G-3a5wA:
22.4
2v41H-3a5wA:
22.5		 2v41G-3a5wA:
33.20
2v41H-3a5wA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 10 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
 None
 0.51A 2vl2A-3a5wA:
16.3
2vl2C-3a5wA:
14.0		 2vl2A-3a5wA:
23.60
2vl2C-3a5wA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		5 / 10 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.33A 3lp1A-3a5wA:
undetectable		 3lp1A-3a5wA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		3 / 3 PRO A  43
THR A 124
LEU A  74
 None
 0.62A 3ttrA-3a5wA:
undetectable		 3ttrA-3a5wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 8 GLU A  53
VAL A 151
GLY A 127
LEU A 141
 None
 0.87A 5sxqA-3a5wA:
undetectable		 5sxqA-3a5wA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 8 GLU A  53
VAL A 151
GLY A 127
LEU A 141
 None
 0.91A 5syjB-3a5wA:
undetectable		 5syjB-3a5wA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3a5w PROBABLE
PEROXIREDOXIN
(Aeropyrum
pernix) 		4 / 5 THR A 108
THR A  19
HIS A  29
LEU A  26
 None
 1.08A 5utuH-3a5wA:
undetectable		 5utuH-3a5wA:
18.07