SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 ASP A 275
TYR A 216
ASN A 223
GLU A 263
 None
 1.33A 1rjdA-3a62A:
undetectable		 1rjdA-3a62A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 ASP A 275
TYR A 216
ASN A 223
GLU A 263
 None
 1.32A 1rjdB-3a62A:
undetectable		 1rjdB-3a62A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 7 LYS A 123
LEU A 147
ILE A 155
ILE A 214
 STU  A 400 ( 4.3A)
None
None
None
 0.68A 1uwjA-3a62A:
6.8		 1uwjA-3a62A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 220
ASN A 223
MET A 225
ASP A 236
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
STU  A 400 (-3.6A)
STU  A 400 ( 3.8A)
 0.97A 2fumA-3a62A:
26.7		 2fumA-3a62A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		9 / 12 LEU A  97
GLY A  98
VAL A 105
ALA A 121
TYR A 174
LYS A 220
ASN A 223
MET A 225
ASP A 236
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 (-4.7A)
None
None
STU  A 400 (-3.6A)
STU  A 400 ( 3.8A)
 1.01A 2fumB-3a62A:
26.8		 2fumB-3a62A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
GLY A  98
VAL A 105
ALA A 121
TYR A 174
ASN A 223
MET A 225
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 (-4.7A)
None
STU  A 400 (-3.6A)
 1.04A 2fumC-3a62A:
25.9		 2fumC-3a62A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 220
ASN A 223
MET A 225
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
STU  A 400 (-3.6A)
 1.09A 2fumD-3a62A:
26.1		 2fumD-3a62A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
GLY A  98
VAL A 105
GLU A 143
LEU A 147
LEU A 170
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
None
STU  A 400 (-4.7A)
 0.66A 2ivuA-3a62A:
23.2		 2ivuA-3a62A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
GLY A  98
VAL A 105
LYS A 123
GLU A 143
LEU A 147
LEU A 170
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.72A 2ivuA-3a62A:
23.2		 2ivuA-3a62A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 THR A 301
TYR A 284
TRP A 277
THR A 256
 None
 1.48A 2qmjA-3a62A:
0.0		 2qmjA-3a62A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 GLY A  98
VAL A 105
ALA A 121
LEU A 172
TYR A 174
GLY A 178
MET A 225
ASP A 236
 STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
STU  A 400 ( 3.8A)
 0.89A 2wgjA-3a62A:
21.8		 2wgjA-3a62A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		5 / 12 GLY A 100
GLY A  98
LEU A 180
GLU A 222
ASP A 236
 None
STU  A 400 (-3.6A)
None
None
STU  A 400 ( 3.8A)
 0.89A 3embA-3a62A:
undetectable		 3embA-3a62A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 LEU A  97
GLY A  98
GLY A 100
GLY A 103
VAL A 105
ALA A 121
LYS A 123
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 (-4.7A)
 0.38A 3fupA-3a62A:
22.7		 3fupA-3a62A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 123
VAL A 156
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 (-4.7A)
 0.49A 3fupB-3a62A:
22.7		 3fupB-3a62A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 123
VAL A 156
TYR A 174
LEU A 175
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 (-4.7A)
STU  A 400 (-3.8A)
 0.56A 3fupB-3a62A:
22.7		 3fupB-3a62A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 123
VAL A 156
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 (-4.7A)
 0.49A 3lxkA-3a62A:
22.8		 3lxkA-3a62A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 123
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 (-4.7A)
 0.39A 3lxnA-3a62A:
22.5		 3lxnA-3a62A:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		5 / 12 LEU A 323
VAL A 346
HIS A 208
ILE A 155
LEU A 219
 None
 1.28A 3sp9B-3a62A:
undetectable		 3sp9B-3a62A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		3 / 3 LYS A 370
PRO A 371
LEU A 372
 None
 0.82A 3tpxE-3a62A:
undetectable		 3tpxE-3a62A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 12 GLY A 100
GLY A 103
VAL A 105
ALA A 121
LEU A 125
VAL A 156
 None
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
 0.75A 3v5wA-3a62A:
11.6		 3v5wA-3a62A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 12 LEU A  97
VAL A 105
ALA A 121
GLU A 143
LEU A 147
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 ( 4.4A)
 0.52A 3wzdA-3a62A:
21.3		 3wzdA-3a62A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 5 LYS A 123
ILE A 146
VAL A 156
ASP A 236
 STU  A 400 ( 4.3A)
None
None
STU  A 400 ( 3.8A)
 0.98A 3wzdA-3a62A:
21.4		 3wzdA-3a62A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 11 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 (-4.7A)
 0.79A 4ckiA-3a62A:
17.2		 4ckiA-3a62A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 GLY A  98
VAL A 105
ALA A 121
LEU A 158
LEU A 170
GLY A 178
GLU A 179
 STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
 0.71A 4ifgA-3a62A:
21.4		 4ifgA-3a62A:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 LEU A  97
GLY A  98
VAL A 105
ALA A 121
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
 0.26A 4o0wA-3a62A:
29.7		 4o0wA-3a62A:
33.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 5 PHE A 352
PHE A 351
LEU A 328
PRO A 292
 None
 1.28A 4o8zA-3a62A:
undetectable		 4o8zA-3a62A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
GLY A  98
GLY A 100
GLY A 103
VAL A 105
ALA A 121
VAL A 156
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
 0.49A 4otiA-3a62A:
25.9		 4otiA-3a62A:
40.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		3 / 3 LEU A 168
MET A 122
TYR A 102
 None
 0.90A 4p6xG-3a62A:
undetectable		 4p6xG-3a62A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 LEU A  97
VAL A 105
LYS A 123
ILE A 155
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
 0.28A 4tyjA-3a62A:
22.2		 4tyjA-3a62A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 LEU A  97
VAL A 105
LYS A 123
ILE A 155
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
 0.66A 4tyjA-3a62A:
22.2		 4tyjA-3a62A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 10 LEU A  97
VAL A 105
GLU A 143
ILE A 155
VAL A 156
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
None
STU  A 400 (-4.7A)
 0.51A 4u0iA-3a62A:
21.8		 4u0iA-3a62A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 5 LEU A 282
ASP A 285
TYR A 198
LEU A 199
 None
 1.18A 4wozF-3a62A:
undetectable
4wozH-3a62A:
undetectable		 4wozF-3a62A:
22.04
4wozH-3a62A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 7 GLY A  98
LEU A 158
ASP A 236
PHE A 237
 STU  A 400 (-3.6A)
None
STU  A 400 ( 3.8A)
None
 0.88A 5hieB-3a62A:
22.9		 5hieB-3a62A:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 11 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LEU A 172
TYR A 174
GLU A 179
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
STU  A 400 (-3.6A)
 0.60A 5lvnA-3a62A:
31.7		 5lvnA-3a62A:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 11 LEU A  97
GLY A  98
VAL A 105
ALA A 121
VAL A 156
LEU A 172
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
 0.51A 5lvnA-3a62A:
31.7		 5lvnA-3a62A:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		8 / 12 GLY A  98
VAL A 105
ALA A 121
GLU A 143
LEU A 172
TYR A 174
GLY A 178
GLU A 179
 STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
 0.92A 5mafA-3a62A:
28.7		 5mafA-3a62A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		5 / 10 LEU A  97
VAL A 105
LYS A 123
GLU A 143
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.45A 5mo4A-3a62A:
18.0		 5mo4A-3a62A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 10 LEU A  97
VAL A 105
ALA A 121
VAL A 156
TYR A 174
THR A 235
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
STU  A 400 (-4.7A)
STU  A 400 (-4.4A)
 0.70A 5n3hA-3a62A:
32.1		 5n3hA-3a62A:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 12 LEU A  97
ALA A 121
LYS A 123
GLU A 143
VAL A 156
LEU A 170
 STU  A 400 (-3.8A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.76A 5vcvA-3a62A:
22.7		 5vcvA-3a62A:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
LEU A 170
GLY A 177
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.84A 5vcyA-3a62A:
22.5		 5vcyA-3a62A:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
LEU A 170
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
STU  A 400 ( 4.4A)
 0.95A 5vcyA-3a62A:
22.5		 5vcyA-3a62A:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		5 / 9 LEU A  97
ALA A 121
GLY A 178
MET A 225
THR A 235
 STU  A 400 (-3.8A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
STU  A 400 (-4.4A)
 0.91A 5w5vA-3a62A:
14.0		 5w5vA-3a62A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 ARG A  95
LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
 None
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.86A 5y7zA-3a62A:
24.5		 5y7zA-3a62A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 ARG A  95
LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
 None
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.86A 5y7zA-3a62A:
24.5		 5y7zA-3a62A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		7 / 12 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
ASP A 236
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
STU  A 400 ( 3.8A)
 0.60A 5y80A-3a62A:
6.5		 5y80A-3a62A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 12 LEU A  97
VAL A 105
ALA A 121
GLU A 143
TYR A 174
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
 0.47A 5zv2A-3a62A:
18.3		 5zv2A-3a62A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 12 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.63A 5zv2B-3a62A:
21.8		 5zv2B-3a62A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 PHE A 253
ARG A 298
ILE A 264
MET A 260
 TPO  A 252 ( 4.1A)
None
None
TPO  A 252 ( 4.2A)
 1.18A 6dhbA-3a62A:
undetectable		 6dhbA-3a62A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		6 / 12 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
VAL A 156
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
 0.48A 6hd6B-3a62A:
21.2		 6hd6B-3a62A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		5 / 11 ILE A 202
HIS A 210
ASP A 342
ALA A 343
GLY A 337
 None
 1.17A 6ieyA-3a62A:
undetectable
6ieyB-3a62A:
undetectable		 6ieyA-3a62A:
19.45
6ieyB-3a62A:
19.45