SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 SER A 478
THR A 476
ASN A 477
TYR A 303
 None
 0.94A 1dssG-3a74A:
undetectable		 1dssG-3a74A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 478
THR A 476
ASN A 477
TYR A 303
 None
 0.93A 1dssR-3a74A:
undetectable		 1dssR-3a74A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 188
GLY A 192
LEU A 194
TYR A 246
 None
 0.90A 1gtiA-3a74A:
undetectable		 1gtiA-3a74A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 188
GLY A 192
LEU A 194
TYR A 246
 None
 0.91A 1gtiB-3a74A:
undetectable		 1gtiB-3a74A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 188
GLY A 192
LEU A 194
TYR A 246
 None
 0.90A 1gtiD-3a74A:
undetectable		 1gtiD-3a74A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 188
GLY A 192
LEU A 194
TYR A 246
 None
 0.90A 1gtiE-3a74A:
undetectable		 1gtiE-3a74A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 283
ASN A 286
ALA A 289
LEU A 471
LEU A 405
 None
 1.46A 1ya3B-3a74A:
undetectable		 1ya3B-3a74A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 477
LEU A 310
LEU A 307
ILE A 407
 None
 1.02A 1z95A-3a74A:
undetectable		 1z95A-3a74A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 413
THR A 284
PHE A 406
 None
 0.78A 2c6nB-3a74A:
undetectable		 2c6nB-3a74A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 283
ASN A 286
ALA A 289
LEU A 471
LEU A 405
 None
 1.45A 2oaxC-3a74A:
undetectable		 2oaxC-3a74A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 389
LEU A 419
LEU A 232
PRO A 422
 None
 0.93A 2vq5B-3a74A:
undetectable		 2vq5B-3a74A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 THR A 284
LEU A 188
LEU A 268
LEU A 270
 None
 0.76A 3bgdB-3a74A:
undetectable		 3bgdB-3a74A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 103
VAL A 130
ALA A  74
VAL A  61
ILE A  86
 None
 1.10A 3czhA-3a74A:
undetectable		 3czhA-3a74A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 478
THR A 476
ASN A 477
TYR A 303
 None
 0.81A 3dmtC-3a74A:
undetectable		 3dmtC-3a74A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 5 THR A 121
VAL A 123
GLY A 124
LYS A 120
 None
 1.08A 3elzA-3a74A:
undetectable		 3elzA-3a74A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 193
GLY A 192
LEU A 194
ASP A 189
 None
 0.96A 3ps9A-3a74A:
undetectable		 3ps9A-3a74A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 283
ASN A 286
ALA A 289
LEU A 471
LEU A 405
 None
 1.45A 3vhuA-3a74A:
undetectable		 3vhuA-3a74A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  36
THR A  83
ILE A 175
 None
 0.79A 4e0fB-3a74A:
undetectable		 4e0fB-3a74A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 9 ASN A 440
ALA A 443
GLY A 206
ILE A 228
ILE A 386
 None
 1.10A 4nptA-3a74A:
undetectable		 4nptA-3a74A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 235
ARG A 236
HIS A 233
 None
 0.97A 4zbrA-3a74A:
undetectable		 4zbrA-3a74A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A 414
ALA A 209
GLU A 418
GLU A 231
LEU A 232
 B4P  A 494 (-3.8A)
None
LYN  A 495 (-2.9A)
LYN  A 495 (-3.0A)
None
 1.35A 4zjoA-3a74A:
1.7		 4zjoA-3a74A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A  90
SER A 106
MET A  66
 None
 0.87A 5ikqA-3a74A:
undetectable		 5ikqA-3a74A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 283
LEU A 287
ASN A 286
ALA A 289
LEU A 471
LEU A 405
 None
 1.35A 5mwyA-3a74A:
undetectable		 5mwyA-3a74A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		7 / 10 ARG A 253
GLU A 255
HIS A 261
PHE A 265
GLY A 467
ARG A 470
ILE A 481
 B4P  A 494 ( 2.7A)
B4P  A 494 (-3.7A)
B4P  A 494 (-3.5A)
B4P  A 494 (-3.4A)
B4P  A 494 (-3.2A)
B4P  A 494 (-2.8A)
None
 0.32A 6bniA-3a74A:
44.7		 6bniA-3a74A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 10 GLU A 255
HIS A 261
GLU A 411
ARG A 470
ILE A 481
 B4P  A 494 (-3.7A)
B4P  A 494 (-3.5A)
B4P  A 494 (-3.4A)
B4P  A 494 (-2.8A)
None
 1.16A 6bniA-3a74A:
44.7		 6bniA-3a74A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		7 / 10 ARG A 253
GLU A 255
HIS A 261
PHE A 265
GLY A 467
ARG A 470
ILE A 481
 B4P  A 494 ( 2.7A)
B4P  A 494 (-3.7A)
B4P  A 494 (-3.5A)
B4P  A 494 (-3.4A)
B4P  A 494 (-3.2A)
B4P  A 494 (-2.8A)
None
 0.35A 6bniB-3a74A:
44.4		 6bniB-3a74A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3a74 LYSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 10 GLU A 255
HIS A 261
GLU A 411
ARG A 470
ILE A 481
 B4P  A 494 (-3.7A)
B4P  A 494 (-3.5A)
B4P  A 494 (-3.4A)
B4P  A 494 (-2.8A)
None
 1.17A 6bniB-3a74A:
44.4		 6bniB-3a74A:
9.07