SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		5 / 12 PHE A  79
GLY A  60
ASN A  82
ILE A  91
VAL A  63
 None
 1.08A 2hmyB-3a75A:
undetectable		 2hmyB-3a75A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.11A 3ag1J-3a75A:
undetectable		 3ag1J-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 6 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.02A 3ag1N-3a75A:
undetectable
3ag1W-3a75A:
undetectable		 3ag1N-3a75A:
23.06
3ag1W-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 7 ASN A 371
ILE A 365
PHE A 308
GLN A 322
 None
 1.27A 3tvxB-3a75A:
undetectable		 3tvxB-3a75A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 8 VAL A  83
LEU A 225
ILE A 170
MET A 166
 None
 0.90A 3u5kA-3a75A:
undetectable		 3u5kA-3a75A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		5 / 12 ILE A  91
THR A 228
ASN A  82
PRO A  86
LEU A 187
 None
 1.11A 3v8vA-3a75A:
undetectable		 3v8vA-3a75A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		5 / 12 LEU A 249
PHE A 229
LEU A 225
ALA A 202
ALA A 203
 None
 1.03A 3vw7A-3a75A:
undetectable		 3vw7A-3a75A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 6 ALA A  70
GLY A  60
LEU A  64
VAL A  63
 None
 0.90A 4dubB-3a75A:
undetectable		 4dubB-3a75A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		5 / 12 LEU A  64
ALA A 157
ALA A  74
VAL A  75
GLY A 162
 None
 1.12A 4hfpD-3a75A:
undetectable		 4hfpD-3a75A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.06A 5w97J-3a75A:
undetectable		 5w97J-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.02A 5x19J-3a75A:
undetectable		 5x19J-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.06A 5x1bJ-3a75A:
undetectable		 5x1bJ-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.07A 5x1bW-3a75A:
undetectable		 5x1bW-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 6 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.08A 5x1fA-3a75A:
undetectable
5x1fJ-3a75A:
undetectable		 5x1fA-3a75A:
23.06
5x1fJ-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.03A 5x1fW-3a75A:
undetectable		 5x1fW-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		5 / 12 PHE A  79
GLY A  60
ASN A  82
ILE A  91
VAL A  63
 None
 1.05A 6mhtA-3a75A:
undetectable		 6mhtA-3a75A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.05A 6nknJ-3a75A:
undetectable		 6nknJ-3a75A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN
(Bacillus
subtilis) 		4 / 5 TYR A 332
MET A 328
THR A 327
LEU A 324
 None
 1.07A 6nknW-3a75A:
undetectable		 6nknW-3a75A:
12.81