SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 11 PRO A 248
LEU A 265
VAL A 348
GLY A 349
LEU A 245
 None
 1.30A 1fkpA-3a77A:
undetectable		 1fkpA-3a77A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 GLU A 310
HIS A 290
ASP A 314
 None
 0.73A 1i9gA-3a77A:
undetectable		 1i9gA-3a77A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 11 PRO A 248
LEU A 265
VAL A 348
GLY A 349
LEU A 245
 None
 1.29A 1lwcA-3a77A:
undetectable		 1lwcA-3a77A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 12 ILE A 395
ASN A 190
LEU A 415
PRO A 191
LEU A 401
 None
None
None
None
SEP  A 402 ( 4.2A)
 1.28A 1mrlB-3a77A:
undetectable
1mrlC-3a77A:
undetectable		 1mrlB-3a77A:
17.07
1mrlC-3a77A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		4 / 8 GLN A 214
GLN A 217
GLU A 205
THR A 207
 None
 0.82A 3rglA-3a77A:
undetectable		 3rglA-3a77A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 12 CYH A 371
LEU A 196
LEU A 281
PHE A 325
TYR A 408
 None
 1.45A 3vn2A-3a77A:
undetectable		 3vn2A-3a77A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		6 / 12 GLY A 271
GLY A 270
GLY A 269
LEU A 228
ALA A 273
VAL A 311
 None
None
None
None
MPD  A3002 (-3.6A)
None
 1.34A 4htfA-3a77A:
undetectable		 4htfA-3a77A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		6 / 12 GLY A 271
GLY A 270
GLY A 269
LEU A 228
ALA A 273
VAL A 311
 None
None
None
None
MPD  A3002 (-3.6A)
None
 1.33A 4htfB-3a77A:
undetectable		 4htfB-3a77A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		4 / 5 GLY A 337
SER A 336
PHE A 332
GLU A 334
 None
 1.00A 4m93B-3a77A:
undetectable
4m93C-3a77A:
undetectable		 4m93B-3a77A:
23.70
4m93C-3a77A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		3 / 3 GLU A 310
HIS A 290
ASP A 314
 None
 0.68A 5c0oG-3a77A:
undetectable		 5c0oG-3a77A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 8 ALA A 374
VAL A 376
VAL A 368
GLU A 205
HIS A 394
 None
 1.39A 5ecnD-3a77A:
undetectable		 5ecnD-3a77A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens) 		5 / 12 ALA A 283
LEU A 281
SER A 396
VAL A 197
LEU A 226
 None
 1.06A 6djzC-3a77A:
undetectable		 6djzC-3a77A:
25.63