SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		4 / 6 MET A 133
LEU A 125
ALA A 128
LEU A 164
 L2P  A 295 (-4.2A)
None
None
None
 0.99A 1etb1-3a7kA:
undetectable		 1etb1-3a7kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 12 LEU A 135
LEU A 138
LEU A 141
ALA A 142
LEU A 195
 None
None
None
None
L3P  A 331 (-3.7A)
 0.52A 1ya3C-3a7kA:
undetectable		 1ya3C-3a7kA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		4 / 8 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.96A 2bfpA-3a7kA:
undetectable		 2bfpA-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		4 / 8 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.97A 2bfpB-3a7kA:
undetectable		 2bfpB-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		4 / 8 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.95A 2bfpC-3a7kA:
undetectable		 2bfpC-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		4 / 8 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.96A 2bfpD-3a7kA:
undetectable		 2bfpD-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 12 TRP A 121
LEU A 125
LEU A 129
GLY A  84
LEU A  89
 None
None
L1P  A 293 ( 4.9A)
L1P  A 293 ( 4.5A)
L1P  A 293 (-4.4A)
 1.05A 2jfaB-3a7kA:
undetectable		 2jfaB-3a7kA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		4 / 7 GLY A 139
ILE A  67
THR A  71
LEU A 138
 None
 1.02A 2xrhA-3a7kA:
undetectable		 2xrhA-3a7kA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 10 THR A 207
GLY A 143
LEU A 141
LEU A 140
ILE A  67
 None
 1.20A 3kvrA-3a7kA:
undetectable		 3kvrA-3a7kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 10 THR A 207
GLY A 143
LEU A 141
LEU A 140
ILE A  67
 None
 1.20A 3kvrB-3a7kA:
undetectable		 3kvrB-3a7kA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 9 THR A 207
GLY A 143
LEU A 141
LEU A 140
ILE A  67
 None
 1.19A 3nbqA-3a7kA:
undetectable		 3nbqA-3a7kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 12 TRP A 121
LEU A 125
LEU A 129
GLY A  84
LEU A  89
 None
None
L1P  A 293 ( 4.9A)
L1P  A 293 ( 4.5A)
L1P  A 293 (-4.4A)
 1.07A 4xi3C-3a7kA:
2.3		 4xi3C-3a7kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3a7k HALORHODOPSIN
(Natronomonas
pharaonis) 		5 / 11 TRP A 246
SER A  37
VAL A 233
GLY A 235
VAL A 228
 L3P  A 333 (-3.6A)
None
None
None
None
 1.26A 6hu9A-3a7kA:
2.5
6hu9E-3a7kA:
0.0
6hu9I-3a7kA:
undetectable		 6hu9A-3a7kA:
20.28
6hu9E-3a7kA:
21.25
6hu9I-3a7kA:
12.97