SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.91A 1hrkA-3a8kA:
undetectable		 1hrkA-3a8kA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		8 / 12 MET A  51
TYR A  84
TYR A 101
VAL A 111
ASN A 113
TYR A 188
ARG A 223
TRP A 252
 None
 0.50A 1wopA-3a8kA:
47.8		 1wopA-3a8kA:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		7 / 12 MET A  51
ILE A  99
VAL A 111
ASN A 113
TYR A 188
ARG A 223
TRP A 252
 None
 0.62A 1wsvA-3a8kA:
46.5		 1wsvA-3a8kA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		6 / 12 MET A  51
ILE A  99
VAL A 111
ASN A 113
TYR A 188
TRP A 252
 None
 0.65A 1wsvB-3a8kA:
46.5		 1wsvB-3a8kA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 PHE A 355
ARG A 357
GLY A 282
THR A 351
 None
 0.95A 2f7fA-3a8kA:
undetectable		 2f7fA-3a8kA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 THR A 189
GLN A 147
ILE A  99
VAL A 111
ALA A 145
 None
 1.24A 2g72B-3a8kA:
undetectable		 2g72B-3a8kA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.91A 2hrcA-3a8kA:
undetectable		 2hrcA-3a8kA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.96A 2hrcB-3a8kA:
undetectable		 2hrcB-3a8kA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.99A 2pnjA-3a8kA:
undetectable		 2pnjA-3a8kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.90A 2po5A-3a8kA:
undetectable		 2po5A-3a8kA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.85A 2po7A-3a8kA:
undetectable		 2po7A-3a8kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.86A 2po7B-3a8kA:
undetectable		 2po7B-3a8kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 ASP A  55
VAL A  54
PHE A 103
THR A  61
 None
 1.47A 2q6oB-3a8kA:
undetectable		 2q6oB-3a8kA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 GLU A 331
PRO A 330
ILE A 333
GLY A 332
 None
 1.09A 2qeuA-3a8kA:
undetectable
2qeuC-3a8kA:
undetectable		 2qeuA-3a8kA:
18.87
2qeuC-3a8kA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 LEU A 291
ARG A 292
ALA A 325
ILE A 341
 None
 1.15A 2qhfA-3a8kA:
undetectable		 2qhfA-3a8kA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		6 / 12 GLY A 282
LEU A 280
ALA A 327
VAL A 284
LEU A 283
VAL A 297
 None
 1.35A 2yqzB-3a8kA:
undetectable		 2yqzB-3a8kA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 GLN A 163
ALA A 178
GLN A 177
ILE A 183
 None
 1.15A 2z0aA-3a8kA:
undetectable		 2z0aA-3a8kA:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		8 / 12 MET A  51
ASP A  96
ILE A  99
TYR A 101
VAL A 111
ASN A 113
MET A 143
ARG A 223
 None
 1.36A 3a8iA-3a8kA:
60.9		 3a8iA-3a8kA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		11 / 12 MET A  51
TYR A  84
ILE A  99
TYR A 101
VAL A 111
ASN A 113
MET A 143
PHE A 173
TYR A 188
ARG A 223
MET A 232
 None
 0.47A 3a8iA-3a8kA:
60.9		 3a8iA-3a8kA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		6 / 12 MET A  51
ASP A  96
TYR A 101
VAL A 111
ASN A 113
ARG A 223
 None
 1.37A 3a8iB-3a8kA:
59.4		 3a8iB-3a8kA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		11 / 12 MET A  51
TYR A  84
ILE A  99
TYR A 101
VAL A 111
ASN A 113
PHE A 173
TYR A 188
ARG A 223
MET A 232
TRP A 252
 None
 0.52A 3a8iB-3a8kA:
59.4		 3a8iB-3a8kA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		12 / 12 MET A  51
TYR A  84
ILE A  99
TYR A 101
VAL A 111
ASN A 113
PHE A 173
THR A 186
TYR A 188
ARG A 223
MET A 232
TRP A 252
 None
 0.49A 3a8iC-3a8kA:
58.8		 3a8iC-3a8kA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		7 / 12 MET A  51
ASP A  96
ILE A  99
TYR A 101
VAL A 111
ASN A 113
ARG A 223
 None
 1.33A 3a8iD-3a8kA:
58.8		 3a8iD-3a8kA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		11 / 12 MET A  51
TYR A  84
ILE A  99
TYR A 101
VAL A 111
ASN A 113
PHE A 173
TYR A 188
ARG A 223
MET A 232
TRP A 252
 None
 0.47A 3a8iD-3a8kA:
58.8		 3a8iD-3a8kA:
99.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		3 / 3 ARG A 273
LEU A 246
THR A 253
 None
 0.80A 3oxcA-3a8kA:
undetectable		 3oxcA-3a8kA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 ALA A 203
LEU A 181
ALA A 155
VAL A 167
VAL A 176
 None
 1.42A 3r9cA-3a8kA:
undetectable		 3r9cA-3a8kA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 ALA A 155
ILE A 196
LEU A 210
ALA A  43
 None
 0.79A 3r9sA-3a8kA:
undetectable		 3r9sA-3a8kA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 8 ALA A 155
ILE A 196
LEU A 210
ALA A  43
 None
 0.75A 3r9tA-3a8kA:
undetectable		 3r9tA-3a8kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 MET A 232
GLY A 231
GLU A 191
ARG A  40
 None
 1.45A 4bqfA-3a8kA:
undetectable		 4bqfA-3a8kA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 GLY A  58
ASP A 106
ILE A 133
ALA A 128
PHE A 131
 None
 1.39A 4wh5A-3a8kA:
undetectable		 4wh5A-3a8kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 8 ASP A 120
LEU A  98
THR A 116
VAL A  94
 None
 1.21A 5ov9B-3a8kA:
undetectable		 5ov9B-3a8kA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 VAL A  48
ARG A 223
GLY A 187
TYR A 188
 None
 0.96A 5x80A-3a8kA:
undetectable
5x80B-3a8kA:
undetectable		 5x80A-3a8kA:
19.89
5x80B-3a8kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 GLY A 187
TYR A 188
VAL A  48
ARG A 223
 None
 1.05A 5x80C-3a8kA:
undetectable
5x80D-3a8kA:
undetectable		 5x80C-3a8kA:
19.89
5x80D-3a8kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 ILE A 333
PHE A 299
ARG A 328
THR A 277
 None
 1.31A 5z84N-3a8kA:
undetectable
5z84W-3a8kA:
undetectable		 5z84N-3a8kA:
22.87
5z84W-3a8kA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 GLY A 282
PHE A 173
ILE A  99
GLY A 187
THR A 189
 None
 1.23A 6e8qA-3a8kA:
undetectable		 6e8qA-3a8kA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		3 / 3 VAL A 329
GLU A 278
ILE A 333
 None
 0.64A 6f7lB-3a8kA:
undetectable		 6f7lB-3a8kA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3a8k AMINOMETHYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 VAL A 176
PHE A  46
MET A  45
GLY A  44
 None
 1.07A 6hd4A-3a8kA:
undetectable		 6hd4A-3a8kA:
15.11