SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		5 / 12 THR A  41
GLY A 128
ALA A 269
LEU A 268
PHE A 132
 PO4  A 900 (-4.6A)
ATP  A 800 (-4.6A)
None
ATP  A 800 (-3.9A)
None
 1.08A 2yvlD-3a8tA:
undetectable		 2yvlD-3a8tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		4 / 8 THR A 265
LEU A 268
GLN A 272
ALA A  38
 None
ATP  A 800 (-3.9A)
ATP  A 800 (-4.4A)
None
 1.01A 3kp6A-3a8tA:
undetectable		 3kp6A-3a8tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		4 / 8 ALA A 182
VAL A 185
ASP A 186
LEU A 189
 None
 0.81A 3roxA-3a8tA:
undetectable		 3roxA-3a8tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		4 / 6 SER A 173
LEU A 177
THR A 292
ARG A 296
 None
 1.44A 3thrB-3a8tA:
undetectable		 3thrB-3a8tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		4 / 7 LEU A 197
THR A  73
ILE A 222
MET A  64
 None
None
ATP  A 800 (-4.3A)
ATP  A 800 (-4.5A)
 0.98A 5fxtA-3a8tA:
undetectable		 5fxtA-3a8tA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		4 / 6 PHE A 227
PRO A 225
THR A  73
ILE A 261
 None
 1.32A 5ih0A-3a8tA:
undetectable		 5ih0A-3a8tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		5 / 10 SER A  61
LEU A 279
LEU A 137
ILE A 276
GLY A  37
 None
 1.28A 6dm0B-3a8tA:
undetectable
6dm0C-3a8tA:
undetectable		 6dm0B-3a8tA:
12.94
6dm0C-3a8tA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE
(Humulus
lupulus) 		3 / 3 LEU A  35
GLY A  37
PHE A 295
 None
 0.62A 6exiC-3a8tA:
undetectable		 6exiC-3a8tA:
12.76