SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 7 GLN X 177
ASP X 178
LEU X 211
SER X 161
 None
 1.24A 1ig3A-3a8uX:
1.5
1ig3B-3a8uX:
undetectable		 1ig3A-3a8uX:
18.60
1ig3B-3a8uX:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 8 LEU X 350
GLY X 293
ILE X  71
GLU X 348
 None
 0.87A 1n13A-3a8uX:
undetectable
1n13F-3a8uX:
undetectable		 1n13A-3a8uX:
7.96
1n13F-3a8uX:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 8 ASP X 117
SER X 118
SER X 120
ASN X 156
 None
PLP  X 450 (-3.8A)
PLP  X 450 (-2.6A)
None
 1.00A 2cmlB-3a8uX:
undetectable		 2cmlB-3a8uX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		3 / 3 LEU X 182
PRO X 183
ARG X 244
 None
 0.63A 2qd4B-3a8uX:
undetectable		 2qd4B-3a8uX:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 7 GLY X 298
PHE X 265
ILE X 102
PHE X 272
 None
 1.01A 2qmzA-3a8uX:
undetectable
2qmzB-3a8uX:
undetectable		 2qmzA-3a8uX:
19.41
2qmzB-3a8uX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		3 / 3 LEU X  56
VAL X 261
ARG X 267
 None
PLP  X 450 (-4.2A)
None
 0.85A 3b0wB-3a8uX:
undetectable		 3b0wB-3a8uX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 12 GLY X 163
GLY X 151
ASN X 168
VAL X 179
GLY X 159
 None
 0.99A 3sglA-3a8uX:
undetectable		 3sglA-3a8uX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 4 ASN X 292
ALA X  64
GLY X  63
THR X 425
 None
 1.18A 4bboC-3a8uX:
undetectable		 4bboC-3a8uX:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU X 186
GLY X 416
GLY X 417
ASN X 168
GLY X 167
 None
 0.99A 4n09D-3a8uX:
undetectable		 4n09D-3a8uX:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 6 ARG X 435
ALA X 439
LEU X 406
SER X  55
 None
 1.12A 4ot2A-3a8uX:
undetectable		 4ot2A-3a8uX:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 7 GLU X 226
ARG X 378
GLY X 233
GLY X 230
 PLP  X 450 (-4.0A)
None
None
None
 0.86A 4rdxA-3a8uX:
undetectable		 4rdxA-3a8uX:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 5 GLY X 151
HIS X 153
GLY X 147
GLU X 226
 None
None
None
PLP  X 450 (-4.0A)
 1.12A 4v20A-3a8uX:
undetectable		 4v20A-3a8uX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 12 GLY X 338
ILE X  71
THR X 291
GLY X 293
GLY X 264
 None
 1.00A 5d4uD-3a8uX:
3.1		 5d4uD-3a8uX:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 12 GLY X 338
ILE X  71
THR X 291
ILE X 295
GLY X 264
 None
 0.94A 5d4uD-3a8uX:
3.1		 5d4uD-3a8uX:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 12 VAL X 113
PHE X 114
LEU X 162
LEU X 283
ALA X 222
 None
 1.03A 5fctB-3a8uX:
undetectable		 5fctB-3a8uX:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 4 LEU X 406
LEU X 444
GLY X 441
GLU X 442
 None
 1.03A 5hhjA-3a8uX:
undetectable		 5hhjA-3a8uX:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 6 PHE X 400
PRO X 399
ARG X 391
ILE X 396
 None
 1.15A 5ih0A-3a8uX:
undetectable		 5ih0A-3a8uX:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 11 ALA X 341
THR X 291
ALA X 294
GLY X  63
ALA X  64
 None
 1.04A 5lf3Y-3a8uX:
undetectable
5lf3Z-3a8uX:
undetectable		 5lf3Y-3a8uX:
18.22
5lf3Z-3a8uX:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		3 / 3 GLY X  63
THR X  61
ASN X 292
 None
 0.63A 5odiG-3a8uX:
undetectable		 5odiG-3a8uX:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU X 345
GLY X 264
GLU X 226
PHE X 258
THR X 263
 None
None
PLP  X 450 (-4.0A)
None
None
 1.20A 5x6yC-3a8uX:
undetectable		 5x6yC-3a8uX:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 6 ASN X 427
TYR X  53
LEU X 382
SER X  57
 None
 0.98A 6a7pB-3a8uX:
undetectable		 6a7pB-3a8uX:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		4 / 6 VAL X 279
LEU X 187
ARG X 378
PRO X 197
 None
 1.33A 6brdB-3a8uX:
undetectable		 6brdB-3a8uX:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		6 / 11 ALA X 341
THR X 291
ALA X 294
ALA X 337
GLY X  63
GLY X  65
 None
 1.36A 6hwdK-3a8uX:
undetectable
6hwdL-3a8uX:
undetectable		 6hwdK-3a8uX:
13.60
6hwdL-3a8uX:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
putida) 		6 / 11 ALA X 341
THR X 291
ALA X 294
ALA X 337
GLY X  63
GLY X  65
 None
 1.36A 6hwdY-3a8uX:
undetectable
6hwdZ-3a8uX:
undetectable		 6hwdY-3a8uX:
13.60
6hwdZ-3a8uX:
11.32