SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		4 / 7 GLY A 295
THR A 236
THR A 292
ILE A 297
 None
 0.94A 1gtnF-3a9cA:
undetectable
1gtnG-3a9cA:
undetectable		 1gtnF-3a9cA:
13.90
1gtnG-3a9cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		4 / 7 GLY A 295
THR A 236
THR A 292
ILE A 297
 None
 0.96A 1gtnJ-3a9cA:
undetectable
1gtnK-3a9cA:
undetectable		 1gtnJ-3a9cA:
13.90
1gtnK-3a9cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		4 / 7 ALA A 209
ILE A 251
ASP A 280
PHE A 279
 None
 0.80A 1upfB-3a9cA:
3.6		 1upfB-3a9cA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		4 / 8 PHE A 279
ILE A 251
ALA A 201
VAL A  67
 None
 0.69A 3me6B-3a9cA:
undetectable		 3me6B-3a9cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		5 / 12 GLY A 119
GLY A 116
ILE A 123
ALA A 145
MET A 231
 None
 1.13A 4kicA-3a9cA:
4.3		 4kicA-3a9cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		5 / 12 GLY A 119
GLY A 116
ILE A 123
ALA A 145
MET A 231
 None
 1.11A 4kicB-3a9cA:
4.3		 4kicB-3a9cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 ASP A  89
ASN A  44
SER A  86
 None
 0.87A 4obwA-3a9cA:
5.9		 4obwA-3a9cA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 PHE A 279
ASP A 280
LEU A 245
 None
 0.75A 5uhbC-3a9cA:
undetectable		 5uhbC-3a9cA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		3 / 3 PHE A 279
ASP A 280
LEU A 245
 None
 0.77A 5uhcC-3a9cA:
undetectable		 5uhcC-3a9cA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT
(Thermococcus
kodakarensis) 		5 / 10 GLY A  23
ALA A  29
SER A  68
LEU A  69
ASN A  71
 None
 1.20A 5x6yB-3a9cA:
undetectable		 5x6yB-3a9cA:
18.06