SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 ASP A 180
ASP A 174
LYS A 187
 TRE  A2001 (-4.0A)
None
None
 1.00A 1lqtB-3a9gA:
undetectable		 1lqtB-3a9gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 ASP A 180
ASP A 174
LYS A 187
 TRE  A2001 (-4.0A)
None
None
 1.00A 1lquB-3a9gA:
undetectable		 1lquB-3a9gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 281
ASP A 220
VAL A 229
ILE A 320
 None
 0.84A 1t7iB-3a9gA:
undetectable		 1t7iB-3a9gA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 ALA A 281
ASP A 220
VAL A 229
ILE A 320
 None
 0.84A 1t7jB-3a9gA:
undetectable		 1t7jB-3a9gA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 SER A 304
GLY A 303
ARG A 352
 None
 0.68A 1t9wA-3a9gA:
undetectable		 1t9wA-3a9gA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.51A 1usqA-3a9gA:
undetectable		 1usqA-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.48A 1usqB-3a9gA:
undetectable		 1usqB-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.50A 1usqC-3a9gA:
undetectable		 1usqC-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.50A 1usqD-3a9gA:
undetectable		 1usqD-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.51A 1usqE-3a9gA:
undetectable		 1usqE-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.50A 1usqF-3a9gA:
undetectable		 1usqF-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  82
LEU A 136
LEU A  60
LEU A  95
 None
 0.95A 2bfpA-3a9gA:
undetectable		 2bfpA-3a9gA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  82
LEU A 136
LEU A  60
LEU A  95
 None
 0.96A 2bfpB-3a9gA:
undetectable		 2bfpB-3a9gA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.50A 2jkjA-3a9gA:
undetectable		 2jkjA-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.49A 2jkjB-3a9gA:
undetectable		 2jkjB-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.50A 2jkjC-3a9gA:
undetectable		 2jkjC-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.50A 2jkjE-3a9gA:
undetectable		 2jkjE-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.51A 2jklA-3a9gA:
undetectable		 2jklA-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.51A 2jklB-3a9gA:
undetectable		 2jklB-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.51A 2jklC-3a9gA:
undetectable		 2jklC-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 PRO A  53
GLY A  55
GLY A  57
TYR A  59
 None
 0.52A 2jklE-3a9gA:
undetectable		 2jklE-3a9gA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PHE A  82
THR A  62
LEU A  95
VAL A 107
 None
 1.09A 2zuhA-3a9gA:
undetectable		 2zuhA-3a9gA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 ILE A 342
SER A  39
ASP A 339
SER A 367
 None
 1.05A 2zw9B-3a9gA:
1.7		 2zw9B-3a9gA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 212
GLY A 248
GLY A 247
LEU A 254
ALA A 178
 None
 0.97A 3douA-3a9gA:
undetectable		 3douA-3a9gA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 THR A 256
GLU A 232
HIS A 152
 None
CA  A1001 ( 4.6A)
None
 0.79A 3g1uB-3a9gA:
undetectable		 3g1uB-3a9gA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		6 / 11 PHE A 311
ILE A 244
ARG A 158
PHE A 283
SER A 282
ILE A 269
 None
 1.37A 4dm8A-3a9gA:
undetectable		 4dm8A-3a9gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 ARG A 190
TRP A 221
GLY A 160
 None
 0.73A 4e7cA-3a9gA:
undetectable		 4e7cA-3a9gA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 PRO A 267
GLY A 234
ALA A 255
GLN A 217
 None
 1.08A 4g0uA-3a9gA:
undetectable		 4g0uA-3a9gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 ASP A 360
LEU A 363
VAL A 335
 None
 0.61A 4jecB-3a9gA:
undetectable		 4jecB-3a9gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 ASN A 122
ARG A 121
ASN A 153
ILE A 151
 None
 0.99A 4k0bA-3a9gA:
undetectable		 4k0bA-3a9gA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 11 HIS A 370
PHE A 289
ASP A 339
ILE A 336
ILE A 342
 None
 1.50A 4ktvC-3a9gA:
undetectable
4ktvD-3a9gA:
undetectable		 4ktvC-3a9gA:
24.48
4ktvD-3a9gA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 124
ILE A 125
LEU A  60
LEU A  68
 None
 1.04A 4l1wA-3a9gA:
undetectable		 4l1wA-3a9gA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 ASN A 122
ARG A 121
ASN A 153
ILE A 151
 None
 0.96A 4l7iA-3a9gA:
undetectable		 4l7iA-3a9gA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 MET A 228
ILE A 146
ILE A 143
VAL A 124
 None
 0.85A 4ojbA-3a9gA:
undetectable		 4ojbA-3a9gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 6 MET A 228
ILE A 146
ILE A 143
VAL A 124
 None
 0.95A 4olmA-3a9gA:
undetectable		 4olmA-3a9gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 11 LEU A  95
LEU A  70
LEU A  97
LEU A  54
ALA A  52
 None
 1.07A 4p65B-3a9gA:
undetectable
4p65D-3a9gA:
undetectable
4p65G-3a9gA:
undetectable
4p65H-3a9gA:
undetectable		 4p65B-3a9gA:
5.95
4p65D-3a9gA:
5.95
4p65G-3a9gA:
4.12
4p65H-3a9gA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 ASP A 144
ALA A 172
ALA A 185
ASN A 153
TYR A 113
 None
 1.30A 4u14A-3a9gA:
undetectable		 4u14A-3a9gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 5 GLY A 257
THR A 256
GLY A 237
GLU A 240
 None
None
None
CA  A1001 (-2.3A)
 0.84A 4v20A-3a9gA:
undetectable		 4v20A-3a9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 5 GLY A 257
THR A 256
GLY A 272
GLU A 240
 None
None
None
CA  A1001 (-2.3A)
 0.88A 4v20A-3a9gA:
undetectable		 4v20A-3a9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  38
VAL A  41
ASP A 360
THR A 346
ASN A 348
 None
 1.46A 4xe0A-3a9gA:
undetectable		 4xe0A-3a9gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 ASP A 339
ASP A 338
TYR A  59
ASP A 337
 None
 0.88A 4xjeA-3a9gA:
undetectable		 4xjeA-3a9gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 124
ILE A 125
LEU A  60
LEU A  68
 None
 1.01A 4xo7A-3a9gA:
undetectable		 4xo7A-3a9gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 ILE A 344
GLY A 280
THR A 231
LEU A 296
 None
 0.95A 4zdzA-3a9gA:
undetectable		 4zdzA-3a9gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 155
GLY A 154
THR A 169
ASN A 215
ILE A 167
 None
 1.20A 4zvmA-3a9gA:
undetectable
4zvmB-3a9gA:
undetectable		 4zvmA-3a9gA:
20.89
4zvmB-3a9gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 155
GLY A 154
THR A 169
ILE A 167
ILE A 219
 None
 1.22A 4zvmA-3a9gA:
undetectable
4zvmB-3a9gA:
undetectable		 4zvmA-3a9gA:
20.89
4zvmB-3a9gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 8 ASP A 339
ASP A 338
TYR A  59
ASP A 337
 None
 0.94A 5cfsA-3a9gA:
undetectable		 5cfsA-3a9gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 7 ILE A 344
GLY A 280
THR A 231
LEU A 296
 None
 0.94A 5esmA-3a9gA:
undetectable		 5esmA-3a9gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 5 ARG A 156
GLN A 217
PRO A 216
ILE A 219
 None
 1.18A 5ki6A-3a9gA:
undetectable		 5ki6A-3a9gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 4 SER A 282
ALA A 281
GLN A 217
THR A 231
 None
 1.43A 5n0rA-3a9gA:
undetectable		 5n0rA-3a9gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 4 SER A 282
ALA A 281
GLN A 217
THR A 231
 None
 1.44A 5n0sA-3a9gA:
undetectable		 5n0sA-3a9gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 4 SER A 282
ALA A 281
GLN A 217
THR A 231
 None
 1.42A 5n0wA-3a9gA:
undetectable		 5n0wA-3a9gA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 4 SER A 282
ALA A 281
GLN A 217
THR A 231
 None
 1.45A 5n0xA-3a9gA:
undetectable		 5n0xA-3a9gA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		4 / 4 VAL A 366
GLY A 341
ASP A 339
ASP A 287
 None
 1.34A 6cjkC-3a9gA:
undetectable		 6cjkC-3a9gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 229
THR A 231
PHE A 311
VAL A 265
TYR A 250
 None
None
None
TRE  A2002 (-3.8A)
None
 1.16A 6drzA-3a9gA:
undetectable		 6drzA-3a9gA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 11 GLY A 127
LEU A 109
ALA A 111
ARG A 123
PHE A  82
 None
 1.01A 6qgbA-3a9gA:
undetectable		 6qgbA-3a9gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 10 GLY A 127
LEU A 109
ALA A 111
ARG A 123
PHE A  82
 None
 1.04A 6qgbB-3a9gA:
undetectable		 6qgbB-3a9gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 10 GLY A 127
LEU A 109
ALA A 111
ARG A 123
PHE A  82
 None
 1.01A 6qgbD-3a9gA:
undetectable		 6qgbD-3a9gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 11 GLY A 127
LEU A 109
ALA A 111
ARG A 123
PHE A  82
 None
 1.02A 6qgbE-3a9gA:
undetectable		 6qgbE-3a9gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 10 GLY A 127
LEU A 109
ALA A 111
ARG A 123
PHE A  82
 None
 1.03A 6qgbF-3a9gA:
undetectable		 6qgbF-3a9gA:
20.30