SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 8 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.63A 1d0vA-3a9lA:
undetectable		 1d0vA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 8 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.67A 1jhaA-3a9lA:
undetectable		 1jhaA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 8 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.66A 1jhqA-3a9lA:
undetectable		 1jhqA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 8 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.61A 1jhvA-3a9lA:
undetectable		 1jhvA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 7 ASN A 154
GLY A 117
THR A 145
SER A  81
 None
None
None
PO4  A 261 (-2.5A)
 0.92A 2o5yH-3a9lA:
undetectable
2o5yL-3a9lA:
undetectable		 2o5yH-3a9lA:
19.51
2o5yL-3a9lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		3 / 3 GLU A 165
HIS A  78
GLU A  45
 PO4  A 261 (-3.2A)
PO4  A 261 (-3.9A)
ZN  A 251 ( 2.1A)
 0.79A 2x45B-3a9lA:
undetectable		 2x45B-3a9lA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		3 / 3 GLU A 165
HIS A  78
GLU A  45
 PO4  A 261 (-3.2A)
PO4  A 261 (-3.9A)
ZN  A 251 ( 2.1A)
 0.81A 2x45C-3a9lA:
undetectable		 2x45C-3a9lA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		5 / 12 GLY A  68
GLY A  42
ALA A  22
HIS A  40
LEU A  77
 None
None
None
ZN  A 251 ( 3.2A)
None
 0.97A 2yqzA-3a9lA:
undetectable		 2yqzA-3a9lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		5 / 12 GLY A  68
GLY A  42
ALA A  22
HIS A  78
LEU A  77
 None
None
None
PO4  A 261 (-3.9A)
None
 1.01A 2yqzA-3a9lA:
undetectable		 2yqzA-3a9lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		5 / 11 GLN A 176
VAL A 188
TYR A 105
ILE A 166
ILE A 135
 None
 1.41A 3ganA-3a9lA:
undetectable		 3ganA-3a9lA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		5 / 9 ASP A 150
HIS A 103
GLU A 165
HIS A  40
ILE A 152
 None
ZN  A 251 ( 3.2A)
PO4  A 261 (-3.2A)
ZN  A 251 ( 3.2A)
None
 1.12A 3hy7A-3a9lA:
undetectable		 3hy7A-3a9lA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 6 GLY A  42
ARG A  76
ILE A  44
LEU A  65
 None
 1.17A 4ac9C-3a9lA:
2.6		 4ac9C-3a9lA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		3 / 3 ARG A 143
LEU A 114
GLU A 165
 None
None
PO4  A 261 (-3.2A)
 0.59A 4l3gF-3a9lA:
undetectable		 4l3gF-3a9lA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 5 GLY A  47
THR A  48
GLY A  43
GLU A  50
 None
 0.97A 4v20A-3a9lA:
undetectable		 4v20A-3a9lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 7 ASN A 184
TYR A  53
LEU A  51
PHE A 102
 None
 1.08A 4yv5A-3a9lA:
1.4		 4yv5A-3a9lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 7 ASN A 184
TYR A  53
LEU A  51
PHE A 102
 None
 1.15A 4yv5B-3a9lA:
1.4		 4yv5B-3a9lA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		4 / 6 ILE A 152
ALA A  89
LEU A  93
ILE A  35
 None
 0.86A 5mvmB-3a9lA:
undetectable
5mvmC-3a9lA:
undetectable		 5mvmB-3a9lA:
18.27
5mvmC-3a9lA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		5 / 10 ILE A 152
PRO A  39
ALA A  89
LEU A  93
ILE A  35
 None
 1.04A 5mvmD-3a9lA:
undetectable
5mvmE-3a9lA:
undetectable		 5mvmD-3a9lA:
18.27
5mvmE-3a9lA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE
(Bacillus
virus
NIT1) 		5 / 9 LEU A  93
ALA A  99
VAL A 100
SER A 101
ASP A  98
 None
 1.22A 6c2mB-3a9lA:
undetectable		 6c2mB-3a9lA:
16.13