SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		3 / 3 THR A 176
PRO A 174
THR A 175
 None
 0.86A 1i3wE-3a9xA:
undetectable		 1i3wE-3a9xA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		3 / 3 THR A 175
THR A 176
PRO A 174
 None
 0.84A 1i3wF-3a9xA:
undetectable		 1i3wF-3a9xA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		3 / 3 THR A 175
THR A 176
PRO A 174
 None
 0.81A 1mnvD-3a9xA:
undetectable		 1mnvD-3a9xA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		3 / 3 THR A 175
THR A 176
PRO A 174
 None
 0.84A 1qfiA-3a9xA:
undetectable		 1qfiA-3a9xA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 12 THR A  84
GLY A  86
ASP A 221
LEU A 236
VAL A 233
 None
PLP  A 501 ( 4.8A)
PLP  A 501 (-2.6A)
None
None
 1.04A 1r30A-3a9xA:
undetectable		 1r30A-3a9xA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 12 LEU A 226
LEU A 241
GLY A  75
ALA A  71
ALA A  68
 None
 1.17A 2bm9C-3a9xA:
2.2		 2bm9C-3a9xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 12 PHE A 240
LEU A 256
ASP A 239
VAL A 238
ALA A 225
 None
 1.31A 2g70A-3a9xA:
undetectable		 2g70A-3a9xA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 12 PHE A 240
LEU A 256
ASP A 239
VAL A 238
ALA A 225
 None
 1.30A 2g72A-3a9xA:
undetectable		 2g72A-3a9xA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		3 / 3 ALA A 223
GLY A  86
SER A 135
 PLP  A 501 (-3.4A)
PLP  A 501 ( 4.8A)
PLP  A 501 ( 3.7A)
 0.58A 2ivuA-3a9xA:
undetectable		 2ivuA-3a9xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 5 ALA A  37
LEU A  30
GLY A 250
THR A  84
 None
 0.80A 3dl9A-3a9xA:
undetectable		 3dl9A-3a9xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 9 VAL A 179
ILE A 197
ALA A 170
VAL A 154
VAL A 163
 None
 1.17A 3me6C-3a9xA:
undetectable		 3me6C-3a9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 9 VAL A 179
ILE A 197
ALA A 170
VAL A 154
VAL A 163
 None
 1.11A 3me6D-3a9xA:
undetectable		 3me6D-3a9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 5 ILE A 136
HIS A 219
VAL A  94
ASN A  91
 None
None
None
PLP  A 501 (-4.5A)
 0.92A 3nneA-3a9xA:
0.0		 3nneA-3a9xA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 6 ILE A 136
HIS A 219
VAL A  94
ASN A  91
 None
None
None
PLP  A 501 (-4.5A)
 1.03A 3nneG-3a9xA:
undetectable		 3nneG-3a9xA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 8 ARG A 173
THR A 152
LEU A 140
ALA A 149
 None
 0.88A 3ns1L-3a9xA:
undetectable		 3ns1L-3a9xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 11 PHE A 248
ALA A 223
THR A 220
VAL A 231
VAL A 233
 None
PLP  A 501 (-3.4A)
None
None
None
 1.10A 3tmzA-3a9xA:
undetectable		 3tmzA-3a9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 5 ASN A 399
ARG A 329
HIS A 331
LEU A 332
 None
 1.00A 4g5jA-3a9xA:
0.0		 4g5jA-3a9xA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		3 / 3 PRO A 393
ASN A 333
HIS A 331
 None
 0.93A 4ma3H-3a9xA:
undetectable
4ma3L-3a9xA:
undetectable		 4ma3H-3a9xA:
19.40
4ma3L-3a9xA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 10 LEU A 367
CYH A 346
LEU A 403
ALA A 369
LEU A 361
 None
 1.12A 4p65A-3a9xA:
undetectable
4p65B-3a9xA:
undetectable
4p65F-3a9xA:
undetectable
4p65H-3a9xA:
undetectable		 4p65A-3a9xA:
5.62
4p65B-3a9xA:
5.57
4p65F-3a9xA:
5.57
4p65H-3a9xA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 10 GLY A  75
LEU A  70
ALA A 297
ASP A 298
SER A 301
 None
 0.95A 4wnuD-3a9xA:
undetectable		 4wnuD-3a9xA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 12 GLU A 285
GLU A 277
GLY A 294
ALA A 297
ILE A 243
 None
 1.29A 4xe5A-3a9xA:
undetectable		 4xe5A-3a9xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 4 GLY A  87
LEU A 267
PHE A 280
ILE A  82
 PLP  A 501 (-3.7A)
None
None
None
 0.94A 4xv2A-3a9xA:
undetectable		 4xv2A-3a9xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 5 THR A 265
GLY A 260
GLU A 234
ASP A 239
 None
 0.96A 5c0oH-3a9xA:
2.6		 5c0oH-3a9xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 8 ALA A  26
HIS A 133
ASN A 186
LYS A 247
ARG A 402
 None
PLP  A 501 (-3.4A)
PLP  A 501 (-3.5A)
PLP  A 501 (-1.4A)
None
 1.08A 5db5A-3a9xA:
39.9
5db5B-3a9xA:
39.7		 5db5A-3a9xA:
27.18
5db5B-3a9xA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 6 PHE A 280
HIS A  96
PRO A 269
LEU A 271
 None
 1.49A 5dzka-3a9xA:
undetectable
5dzko-3a9xA:
undetectable		 5dzka-3a9xA:
20.24
5dzko-3a9xA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		4 / 5 PRO A 288
ALA A 291
ALA A  41
ILE A  62
 None
 0.61A 5jncD-3a9xA:
undetectable		 5jncD-3a9xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3a9x SELENOCYSTEINE LYASE
(Rattus
norvegicus) 		5 / 12 ILE A 253
GLY A 254
ILE A 243
ILE A  63
ILE A 290
 None
 1.05A 6emuB-3a9xA:
undetectable		 6emuB-3a9xA:
18.33