SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 THR A 260
HIS A 229
HIS A 182
VAL A 108
TYR A  34
 None
ZN  A 303 ( 3.3A)
ZN  A 303 ( 3.2A)
None
None
 1.25A 1j36A-3aalA:
undetectable		 1j36A-3aalA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 THR A 260
HIS A 229
HIS A 182
VAL A 108
TYR A  34
 None
ZN  A 303 ( 3.3A)
ZN  A 303 ( 3.2A)
None
None
 1.25A 1j36B-3aalA:
undetectable		 1j36B-3aalA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 GLY A  77
PHE A  85
ASN A  81
ILE A 126
LEU A 109
 None
 1.29A 1lhuA-3aalA:
undetectable		 1lhuA-3aalA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ASP A 179
GLU A 145
HIS A 214
ARG A 228
GLU A 259
 FE  A 302 ( 3.2A)
FE  A 301 (-2.6A)
FE  A 302 (-3.4A)
None
FE  A 302 ( 2.4A)
 1.39A 1rnrB-3aalA:
undetectable		 1rnrB-3aalA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 8 GLU A 259
HIS A 229
ASP A 179
HIS A 214
 FE  A 302 ( 2.4A)
ZN  A 303 ( 3.3A)
FE  A 302 ( 3.2A)
FE  A 302 (-3.4A)
 0.99A 1v7zD-3aalA:
undetectable		 1v7zD-3aalA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 8 GLU A 259
HIS A 229
ASP A 179
HIS A 214
 FE  A 302 ( 2.4A)
ZN  A 303 ( 3.3A)
FE  A 302 ( 3.2A)
FE  A 302 (-3.4A)
 0.99A 1v7zE-3aalA:
undetectable		 1v7zE-3aalA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 8 TYR A 188
GLY A 155
GLY A 149
ALA A 186
ALA A 148
 None
 1.46A 2ej3C-3aalA:
undetectable		 2ej3C-3aalA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 11 ILE A 237
LEU A 213
LEU A 242
ILE A 215
THR A 260
 None
 1.07A 3a50B-3aalA:
undetectable		 3a50B-3aalA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 11 ILE A 237
LEU A 213
LEU A 242
ILE A 215
THR A 260
 None
 1.03A 3a50C-3aalA:
undetectable		 3a50C-3aalA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ILE A 237
LEU A 213
LEU A 242
ILE A 215
THR A 260
 None
 0.96A 3a50E-3aalA:
undetectable		 3a50E-3aalA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 10 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.14A 3eqmA-3aalA:
undetectable		 3eqmA-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 10 ALA A  70
LEU A 107
ALA A 104
ILE A 102
LEU A  49
 None
 1.00A 3fl9A-3aalA:
undetectable		 3fl9A-3aalA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 10 ALA A  70
LEU A 107
ALA A 104
ILE A 102
LEU A  49
 None
 0.97A 3fl9F-3aalA:
undetectable		 3fl9F-3aalA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 5 HIS A  61
ALA A  24
GLU A  21
HIS A  57
 None
 1.18A 3mbgB-3aalA:
0.0
3mbgC-3aalA:
0.0		 3mbgB-3aalA:
19.03
3mbgC-3aalA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 5 GLU A  21
HIS A  57
HIS A  61
ALA A  24
 None
 1.18A 3mbgB-3aalA:
0.0
3mbgC-3aalA:
0.0		 3mbgB-3aalA:
19.03
3mbgC-3aalA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 207
 None
None
FE  A 302 ( 3.2A)
None
None
 1.15A 3s79A-3aalA:
undetectable		 3s79A-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.15A 3s79A-3aalA:
undetectable		 3s79A-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 GLY A 112
TYR A  34
VAL A  67
VAL A 212
HIS A 214
 None
None
None
None
FE  A 302 (-3.4A)
 1.37A 4ffwA-3aalA:
undetectable		 4ffwA-3aalA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 GLY A 112
TYR A  34
VAL A  67
VAL A 212
HIS A 214
 None
None
None
None
FE  A 302 (-3.4A)
 1.38A 4ffwB-3aalA:
undetectable		 4ffwB-3aalA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 7 HIS A 110
HIS A 229
ASN A 216
HIS A 182
 FE  A 301 ( 3.2A)
ZN  A 303 ( 3.3A)
CAC  A 300 ( 4.8A)
ZN  A 303 ( 3.2A)
 0.98A 4p6sB-3aalA:
undetectable		 4p6sB-3aalA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 GLY A 103
ALA A 104
VAL A  68
GLU A  95
ILE A  46
 None
 1.21A 4pd5A-3aalA:
undetectable		 4pd5A-3aalA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		3 / 3 THR A 260
HIS A 248
LEU A 213
 None
 0.87A 5axdC-3aalA:
undetectable		 5axdC-3aalA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 7 HIS A 110
HIS A 229
ASN A 216
HIS A 182
 FE  A 301 ( 3.2A)
ZN  A 303 ( 3.3A)
CAC  A 300 ( 4.8A)
ZN  A 303 ( 3.2A)
 0.92A 5i3aA-3aalA:
undetectable		 5i3aA-3aalA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 7 HIS A 110
HIS A 229
ASN A 216
HIS A 182
 FE  A 301 ( 3.2A)
ZN  A 303 ( 3.3A)
CAC  A 300 ( 4.8A)
ZN  A 303 ( 3.2A)
 0.91A 5i3aB-3aalA:
undetectable		 5i3aB-3aalA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 207
 None
None
FE  A 302 ( 3.2A)
None
None
 1.12A 5jkvA-3aalA:
undetectable		 5jkvA-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.11A 5jkvA-3aalA:
undetectable		 5jkvA-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 11 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.21A 5jkwA-3aalA:
undetectable		 5jkwA-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 10 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.20A 5jl7A-3aalA:
undetectable		 5jl7A-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		4 / 6 HIS A  69
ASP A 179
HIS A 182
HIS A 214
 FE  A 301 (-3.4A)
FE  A 302 ( 3.2A)
ZN  A 303 ( 3.2A)
FE  A 302 (-3.4A)
 1.08A 5nelB-3aalA:
2.6
5nelC-3aalA:
2.8		 5nelB-3aalA:
21.94
5nelC-3aalA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 11 HIS A 110
HIS A 229
ASN A 216
HIS A 182
HIS A 214
 FE  A 301 ( 3.2A)
ZN  A 303 ( 3.3A)
CAC  A 300 ( 4.8A)
ZN  A 303 ( 3.2A)
FE  A 302 (-3.4A)
 1.03A 5z0fA-3aalA:
undetectable
5z0fB-3aalA:
undetectable		 5z0fA-3aalA:
15.22
5z0fB-3aalA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 11 HIS A 110
HIS A 229
ASN A 216
HIS A 182
HIS A 214
 FE  A 301 ( 3.2A)
ZN  A 303 ( 3.3A)
CAC  A 300 ( 4.8A)
ZN  A 303 ( 3.2A)
FE  A 302 (-3.4A)
 1.00A 5z0gA-3aalA:
undetectable
5z0gB-3aalA:
undetectable		 5z0gA-3aalA:
15.22
5z0gB-3aalA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3aal PROBABLE
ENDONUCLEASE 4
(Geobacillus
kaustophilus) 		5 / 12 ASN A 216
PRO A 261
VAL A 263
ILE A 215
ILE A 294
 CAC  A 300 ( 4.8A)
None
None
None
None
 1.31A 6j20A-3aalA:
undetectable		 6j20A-3aalA:
20.49