SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 5 HIS A  69
SER A  86
LEU A  82
GLY A 110
 PO4  A 272 (-4.0A)
None
None
None
 1.11A 1a4lB-3aamA:
7.0		 1a4lB-3aamA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 8 PHE A 152
HIS A 172
LEU A 168
VAL A 187
 None
MN  A 271 ( 3.4A)
None
None
 0.88A 1fslA-3aamA:
undetectable		 1fslA-3aamA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.39A 1v7zA-3aamA:
2.7		 1v7zA-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.40A 1v7zB-3aamA:
2.7		 1v7zB-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.40A 1v7zC-3aamA:
2.7		 1v7zC-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.39A 1v7zD-3aamA:
2.7		 1v7zD-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.38A 1v7zE-3aamA:
2.7		 1v7zE-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.40A 1v7zF-3aamA:
2.6		 1v7zF-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 11 LEU A 136
ALA A  97
ILE A  33
VAL A 107
VAL A 105
 None
 0.97A 2nnpB-3aamA:
undetectable		 2nnpB-3aamA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		3 / 3 LEU A 185
PRO A 184
LEU A 188
 None
 0.61A 2po5B-3aamA:
2.1		 2po5B-3aamA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.39A 3a6jA-3aamA:
2.7		 3a6jA-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 7 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.38A 3a6jB-3aamA:
undetectable		 3a6jB-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.39A 3a6jC-3aamA:
undetectable		 3a6jC-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.37A 3a6jE-3aamA:
2.5		 3a6jE-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 8 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.40A 3a6jF-3aamA:
undetectable		 3a6jF-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A  94
 None
 1.02A 3hs6A-3aamA:
undetectable		 3hs6A-3aamA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 125
 None
 0.89A 3hs6A-3aamA:
undetectable		 3hs6A-3aamA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 5 HIS A 108
GLU A 139
HIS A 172
HIS A 219
 PO4  A 272 ( 4.9A)
PO4  A 272 (-2.9A)
MN  A 271 ( 3.4A)
MN  A 271 ( 3.4A)
 0.95A 3likA-3aamA:
undetectable		 3likA-3aamA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 5 HIS A 108
GLU A 139
HIS A 172
HIS A 219
 PO4  A 272 ( 4.9A)
PO4  A 272 (-2.9A)
MN  A 271 ( 3.4A)
MN  A 271 ( 3.4A)
 0.97A 3lkaA-3aamA:
undetectable		 3lkaA-3aamA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.05A 3nt1A-3aamA:
undetectable		 3nt1A-3aamA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.03A 3nt1B-3aamA:
undetectable		 3nt1B-3aamA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 10 LEU A 136
ASP A 169
VAL A 166
GLY A 149
VAL A 148
 None
MN  A 271 ( 4.7A)
None
None
None
 1.02A 3oxwA-3aamA:
undetectable		 3oxwA-3aamA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.07A 3pghD-3aamA:
undetectable		 3pghD-3aamA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 ILE A 246
LEU A   8
GLU A  22
ARG A 251
ASP A 256
 None
 1.16A 4b9zA-3aamA:
7.0		 4b9zA-3aamA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		3 / 3 LEU A  57
GLU A  59
SER A  61
 None
 0.71A 4ccqA-3aamA:
2.2		 4ccqA-3aamA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.07A 4coxB-3aamA:
undetectable		 4coxB-3aamA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.07A 4coxC-3aamA:
undetectable		 4coxC-3aamA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.09A 4coxD-3aamA:
undetectable		 4coxD-3aamA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 6 ALA A  53
GLY A  18
LEU A  57
VAL A  20
 None
 0.82A 4dubB-3aamA:
undetectable		 4dubB-3aamA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 7 HIS A  69
HIS A 204
HIS A 172
ASN A 140
VAL A 106
 PO4  A 272 (-4.0A)
PO4  A 272 ( 4.4A)
MN  A 271 ( 3.4A)
None
None
 1.04A 4p6sA-3aamA:
undetectable		 4p6sA-3aamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 7 HIS A  69
HIS A 204
HIS A 172
ASN A 140
VAL A 106
 PO4  A 272 (-4.0A)
PO4  A 272 ( 4.4A)
MN  A 271 ( 3.4A)
None
None
 1.02A 4p6sB-3aamA:
undetectable		 4p6sB-3aamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 GLY A   5
ASP A 256
ASN A 259
GLU A  22
ALA A  23
 None
 1.22A 4pclA-3aamA:
3.4		 4pclA-3aamA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 9 THR A 170
ALA A 173
GLY A 228
GLY A 230
ASP A 179
 None
 1.14A 4qwuK-3aamA:
undetectable
4qwuL-3aamA:
undetectable		 4qwuK-3aamA:
23.81
4qwuL-3aamA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 9 THR A 170
ALA A 173
GLY A 228
GLY A 230
ASP A 179
 None
 1.08A 4qwuY-3aamA:
undetectable
4qwuZ-3aamA:
undetectable		 4qwuY-3aamA:
23.81
4qwuZ-3aamA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 7 HIS A  69
HIS A 204
HIS A 172
ASN A 140
VAL A 106
 PO4  A 272 (-4.0A)
PO4  A 272 ( 4.4A)
MN  A 271 ( 3.4A)
None
None
 1.02A 5i3aA-3aamA:
undetectable		 5i3aA-3aamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 7 HIS A  69
HIS A 204
HIS A 172
ASN A 140
VAL A 106
 PO4  A 272 (-4.0A)
PO4  A 272 ( 4.4A)
MN  A 271 ( 3.4A)
None
None
 1.03A 5i3aB-3aamA:
undetectable		 5i3aB-3aamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 7 HIS A  69
HIS A 204
HIS A 172
ASN A 140
VAL A 106
 PO4  A 272 (-4.0A)
PO4  A 272 ( 4.4A)
MN  A 271 ( 3.4A)
None
None
 1.01A 5i3bA-3aamA:
undetectable		 5i3bA-3aamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.09A 5jvzA-3aamA:
undetectable		 5jvzA-3aamA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 117
GLY A 120
ALA A 121
LEU A 136
 None
 1.08A 5kirA-3aamA:
undetectable		 5kirA-3aamA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 10 HIS A  69
HIS A 204
HIS A 172
ASN A 140
LEU A 155
 PO4  A 272 (-4.0A)
PO4  A 272 ( 4.4A)
MN  A 271 ( 3.4A)
None
None
 1.28A 5m8nB-3aamA:
undetectable		 5m8nB-3aamA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 6 HIS A 108
HIS A 219
HIS A 172
HIS A  69
 PO4  A 272 ( 4.9A)
MN  A 271 ( 3.4A)
MN  A 271 ( 3.4A)
PO4  A 272 (-4.0A)
 0.99A 5nelB-3aamA:
2.2
5nelC-3aamA:
4.2		 5nelB-3aamA:
23.67
5nelC-3aamA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 6 LEU A 247
PHE A 245
PHE A 263
LEU A 222
 None
 1.12A 5x19P-3aamA:
undetectable		 5x19P-3aamA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		4 / 5 GLU A 139
ASP A 217
HIS A 219
THR A 141
 PO4  A 272 (-2.9A)
MN  A 271 (-2.1A)
MN  A 271 ( 3.4A)
None
 1.49A 6b58A-3aamA:
undetectable		 6b58A-3aamA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3aam ENDONUCLEASE IV
(Thermus
thermophilus) 		5 / 10 GLY A 120
VAL A 105
VAL A  74
ALA A  70
LEU A 136
 None
 1.01A 6czmA-3aamA:
undetectable
6czmC-3aamA:
undetectable		 6czmA-3aamA:
21.92
6czmC-3aamA:
21.92