SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 12 ILE A 194
ALA A 160
SER A 205
ILE A 204
LEU A 285
 None
 1.06A 1ddsB-3aarA:
undetectable		 1ddsB-3aarA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 SER A 225
SER A 191
LEU A 227
ALA A 119
LEU A 123
 None
 1.45A 1hwkB-3aarA:
undetectable		 1hwkB-3aarA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 SER A 225
SER A 191
LEU A 227
ALA A 119
LEU A 123
 None
 1.45A 1hwkA-3aarA:
undetectable		 1hwkA-3aarA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 SER A 225
SER A 191
LEU A 227
ALA A 119
LEU A 123
 None
 1.45A 1hwkD-3aarA:
undetectable		 1hwkD-3aarA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 SER A 225
SER A 191
LEU A 227
ALA A 119
LEU A 123
 None
 1.45A 1hwkC-3aarA:
undetectable		 1hwkC-3aarA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifA-3aarA:
undetectable		 1kifA-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifB-3aarA:
undetectable		 1kifB-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifC-3aarA:
undetectable		 1kifC-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifD-3aarA:
undetectable		 1kifD-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifE-3aarA:
undetectable		 1kifE-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifF-3aarA:
undetectable		 1kifF-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifG-3aarA:
undetectable		 1kifG-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifH-3aarA:
undetectable		 1kifH-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 12 LEU A 337
SER A 306
PHE A 309
ILE A 329
TRP A 334
 None
 1.40A 1ot7B-3aarA:
undetectable		 1ot7B-3aarA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		6 / 12 ALA A  50
GLY A  54
GLY A  84
ILE A 154
ASP A 158
GLY A 156
 None
 1.42A 1sqfA-3aarA:
undetectable		 1sqfA-3aarA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.16A 1ve9A-3aarA:
undetectable		 1ve9A-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 8 GLY A  84
GLY A  51
THR A 118
ALA A 117
ALA A  50
 None
ANP  A   1 ( 4.6A)
None
None
None
 1.36A 2ej3C-3aarA:
undetectable		 2ej3C-3aarA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 10 ALA A 117
THR A 118
ALA A 119
GLY A  84
ALA A  86
 None
 0.99A 2f16K-3aarA:
undetectable
2f16L-3aarA:
undetectable		 2f16K-3aarA:
20.69
2f16L-3aarA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 10 ALA A 117
THR A 118
ALA A 119
GLY A  84
ALA A  86
 None
 0.99A 2f16Y-3aarA:
undetectable
2f16Z-3aarA:
undetectable		 2f16Y-3aarA:
20.69
2f16Z-3aarA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 7 GLY A 299
TYR A 356
ASN A 302
ASP A 383
 ANP  A   1 (-2.8A)
None
ANP  A   1 (-4.0A)
None
 1.03A 2g72B-3aarA:
undetectable		 2g72B-3aarA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 7 PHE A 309
LEU A 321
LEU A 316
PRO A 378
 None
 1.06A 2jn3A-3aarA:
undetectable		 2jn3A-3aarA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 12 ILE A 300
GLY A 298
GLY A 299
LEU A 321
GLY A 189
 None
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
ANP  A   1 (-3.4A)
 0.81A 4e3aB-3aarA:
undetectable		 4e3aB-3aarA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 9 SER A  55
ALA A 117
THR A 118
GLY A  84
ALA A  86
 None
 0.92A 5d0xK-3aarA:
undetectable
5d0xL-3aarA:
undetectable		 5d0xK-3aarA:
20.69
5d0xL-3aarA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 9 SER A  55
ALA A 117
THR A 118
GLY A  84
ALA A  86
 None
 0.92A 5d0xY-3aarA:
undetectable
5d0xZ-3aarA:
undetectable		 5d0xY-3aarA:
20.69
5d0xZ-3aarA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 7 GLU A 159
GLY A 189
SER A 191
GLY A 228
 None
ANP  A   1 (-3.4A)
None
None
 0.83A 5e26A-3aarA:
5.9
5e26B-3aarA:
5.4		 5e26A-3aarA:
21.48
5e26B-3aarA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 7 GLU A 159
GLY A 189
SER A 191
GLY A 228
 None
ANP  A   1 (-3.4A)
None
None
 0.85A 5e26A-3aarA:
5.9
5e26B-3aarA:
5.5		 5e26A-3aarA:
21.48
5e26B-3aarA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 7 GLU A 159
GLY A 189
SER A 191
GLY A 228
 None
ANP  A   1 (-3.4A)
None
None
 0.86A 5e26C-3aarA:
5.5
5e26D-3aarA:
5.5		 5e26C-3aarA:
21.48
5e26D-3aarA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 8 GLU A 159
GLY A 189
SER A 191
GLY A 228
 None
ANP  A   1 (-3.4A)
None
None
 0.84A 5e26C-3aarA:
5.5
5e26D-3aarA:
5.5		 5e26C-3aarA:
21.48
5e26D-3aarA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 6 SER A 355
GLY A 259
ASN A 260
ILE A 329
 None
 0.93A 5j4nA-3aarA:
undetectable		 5j4nA-3aarA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 12 LEU A 165
GLY A 387
VAL A 389
PHE A 162
LEU A 161
 None
 1.38A 5jo9A-3aarA:
undetectable		 5jo9A-3aarA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		4 / 5 GLU A 159
GLY A 189
SER A 191
GLY A 228
 None
ANP  A   1 (-3.4A)
None
None
 0.79A 5kprA-3aarA:
5.2		 5kprA-3aarA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  54
GLY A  84
 None
 0.89A 5lf3K-3aarA:
undetectable
5lf3L-3aarA:
undetectable		 5lf3K-3aarA:
21.07
5lf3L-3aarA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  54
GLY A  84
 None
 0.89A 5lf3Y-3aarA:
undetectable
5lf3Z-3aarA:
undetectable		 5lf3Y-3aarA:
21.07
5lf3Z-3aarA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  54
GLY A  84
 None
 0.92A 5lf7K-3aarA:
undetectable
5lf7L-3aarA:
undetectable		 5lf7K-3aarA:
21.07
5lf7L-3aarA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  84
ALA A  86
 None
 0.97A 5lf7K-3aarA:
undetectable
5lf7L-3aarA:
undetectable		 5lf7K-3aarA:
21.07
5lf7L-3aarA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  54
GLY A  84
 None
 0.91A 5lf7Y-3aarA:
undetectable
5lf7Z-3aarA:
undetectable		 5lf7Y-3aarA:
21.07
5lf7Z-3aarA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  84
ALA A  86
 None
 0.95A 5lf7Y-3aarA:
undetectable
5lf7Z-3aarA:
undetectable		 5lf7Y-3aarA:
21.07
5lf7Z-3aarA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 10 THR A  94
ILE A  95
LEU A  99
GLY A  84
PHE A  85
 None
 1.04A 5mxbA-3aarA:
undetectable		 5mxbA-3aarA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 9 VAL A 182
GLY A 183
ILE A 386
LEU A 390
ASP A 172
 None
 1.37A 6c2mC-3aarA:
undetectable		 6c2mC-3aarA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  54
GLY A  84
 None
 0.88A 6hwdK-3aarA:
undetectable
6hwdL-3aarA:
undetectable		 6hwdK-3aarA:
16.94
6hwdL-3aarA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I
(Legionella
pneumophila) 		5 / 11 ALA A 117
THR A 118
ALA A 119
GLY A  54
GLY A  84
 None
 0.88A 6hwdY-3aarA:
undetectable
6hwdZ-3aarA:
undetectable		 6hwdY-3aarA:
16.94
6hwdZ-3aarA:
12.61