SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A  87
LYS A  98
ALA A 100
THR A 271
 None
 0.91A 1ie4B-3aatA:
undetectable
1ie4D-3aatA:
undetectable		 1ie4B-3aatA:
17.03
1ie4D-3aatA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 PHE A  88
SER A  92
ALA A 237
LEU A 240
ALA A 244
 None
 1.41A 1jb0B-3aatA:
undetectable		 1jb0B-3aatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 410 (-2.4A)
PLP  A 410 (-3.2A)
None
None
 0.99A 1meiA-3aatA:
undetectable		 1meiA-3aatA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 365
HIS A 166
ILE A 353
PHE A 337
ILE A 404
 None
 1.25A 1ot7B-3aatA:
undetectable		 1ot7B-3aatA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 390
GLY A 197
ILE A 330
ILE A 198
TYR A 161
 None
 1.10A 1x1aA-3aatA:
5.0		 1x1aA-3aatA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A 256
PHE A  79
ALA A 253
LEU A  87
 None
 1.18A 1x8vA-3aatA:
undetectable		 1x8vA-3aatA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 SER A 212
TRP A 205
PHE A 188
PHE A 221
HIS A 247
 None
 1.39A 1y7iB-3aatA:
3.8		 1y7iB-3aatA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 CYH A 270
SER A 254
LEU A 112
LEU A 250
LEU A  87
 None
 1.45A 2prgB-3aatA:
undetectable		 2prgB-3aatA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 330
GLN A 331
ASN A 357
GLY A 227
LEU A 323
 None
 1.07A 2zw9A-3aatA:
3.3		 2zw9A-3aatA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  20
CYH A 401
ALA A 381
VAL A 387
PHE A 337
 None
 1.19A 3b0wA-3aatA:
undetectable		 3b0wA-3aatA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  20
CYH A 401
ALA A 381
VAL A 387
PHE A 337
 None
 1.23A 3b0wB-3aatA:
undetectable		 3b0wB-3aatA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ASP A 236
ASP A 199
GLY A 358
ILE A 330
 None
 0.83A 3el9A-3aatA:
undetectable		 3el9A-3aatA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 CYH A 270
PRO A 106
ASP A 117
 None
 0.92A 3hlwB-3aatA:
undetectable		 3hlwB-3aatA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		6 / 10 PHE A 260
VAL A 267
GLY A 268
VAL A  53
TRP A 319
GLY A 302
 None
 1.48A 3km6A-3aatA:
undetectable		 3km6A-3aatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 PHE A 260
VAL A 267
VAL A  53
TRP A 319
GLY A 302
 None
 1.49A 3km6B-3aatA:
undetectable		 3km6B-3aatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		6 / 9 PHE A 260
VAL A 267
GLY A 268
VAL A  53
TRP A 319
GLY A 302
 None
 1.49A 3kmoA-3aatA:
undetectable		 3kmoA-3aatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 365
VAL A 408
LEU A  35
ALA A 403
ALA A 381
 None
 1.08A 3mdvA-3aatA:
undetectable		 3mdvA-3aatA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 PHE A  88
SER A  92
ALA A 237
LEU A 240
ALA A 244
 None
 1.41A 3pcqB-3aatA:
undetectable		 3pcqB-3aatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 HIS A 143
VAL A 133
HIS A 189
TYR A 225
LEU A 220
 None
None
PLP  A 410 (-4.4A)
PLP  A 410 (-4.1A)
None
 1.48A 3whxA-3aatA:
undetectable
3whxB-3aatA:
undetectable		 3whxA-3aatA:
18.72
3whxB-3aatA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 272
ALA A 115
VAL A 133
ILE A 251
 None
 0.81A 3wsjB-3aatA:
undetectable		 3wsjB-3aatA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 CYH A 270
SER A 254
LEU A 112
LEU A 250
LEU A  87
 None
 1.44A 4emaA-3aatA:
undetectable		 4emaA-3aatA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 410 (-2.4A)
PLP  A 410 (-3.2A)
None
None
 0.89A 4fo4A-3aatA:
undetectable		 4fo4A-3aatA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 410 (-2.4A)
PLP  A 410 (-3.2A)
None
None
 0.87A 4fo4B-3aatA:
undetectable		 4fo4B-3aatA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A 358
GLY A 197
GLN A 356
ILE A 330
ASN A 194
 None
None
None
None
SO4  A 411 ( 3.1A)
 1.08A 4fr0A-3aatA:
undetectable		 4fr0A-3aatA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 CYH A 270
SER A 254
LEU A 112
LEU A 250
LEU A  87
 None
 1.39A 4o8fB-3aatA:
undetectable		 4o8fB-3aatA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ALA A 159
TYR A 158
PRO A 200
 None
 0.68A 4zdyA-3aatA:
undetectable		 4zdyA-3aatA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ALA A 159
TYR A 158
PRO A 200
GLY A 231
 None
 0.79A 5eslA-3aatA:
undetectable		 5eslA-3aatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 PHE A  88
SER A  92
ALA A 237
LEU A 240
ALA A 244
 None
 1.43A 5oy0b-3aatA:
undetectable		 5oy0b-3aatA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 CYH A 270
SER A 254
LEU A 112
LEU A 250
LEU A  87
 None
 1.45A 5y2oA-3aatA:
undetectable		 5y2oA-3aatA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A 107
THR A 109
GLY A 110
THR A  83
PHE A  79
 PLP  A 410 (-4.7A)
PLP  A 410 (-3.4A)
None
None
None
 1.18A 5ybbA-3aatA:
undetectable		 5ybbA-3aatA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 271
ALA A 100
LYS A  98
 None
 0.68A 6fgcA-3aatA:
undetectable		 6fgcA-3aatA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3aat ASPARTATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 271
ALA A 100
LYS A  98
 None
 0.65A 6fgdA-3aatA:
2.2		 6fgdA-3aatA:
22.54