SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ab1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 ALA A  66
LEU A 313
SER A  79
LEU A  53
ILE A  62
 None
None
None
FAD  A 361 (-4.8A)
FAD  A 361 ( 4.1A)
 0.84A 1dhiA-3ab1A:
2.1		 1dhiA-3ab1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 ALA A  66
LEU A 313
SER A  79
LEU A  53
ILE A  62
 None
None
None
FAD  A 361 (-4.8A)
FAD  A 361 ( 4.1A)
 0.86A 1dhjA-3ab1A:
2.1		 1dhjA-3ab1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 ALA A  66
LEU A 313
SER A  79
LEU A  53
ILE A  62
 None
None
None
FAD  A 361 (-4.8A)
FAD  A 361 ( 4.1A)
 0.87A 1draA-3ab1A:
undetectable		 1draA-3ab1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 ALA A  66
LEU A 313
SER A  79
LEU A  53
ILE A  62
 None
None
None
FAD  A 361 (-4.8A)
FAD  A 361 ( 4.1A)
 0.88A 1drbA-3ab1A:
2.1		 1drbA-3ab1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 ALA A  66
LEU A 313
SER A  79
LEU A  53
ILE A  62
 None
None
None
FAD  A 361 (-4.8A)
FAD  A 361 ( 4.1A)
 0.91A 2drcA-3ab1A:
undetectable		 2drcA-3ab1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 GLY A  22
GLY A  26
ILE A  74
GLY A  51
GLY A  50
 FAD  A 361 ( 4.7A)
None
None
FAD  A 361 (-3.0A)
None
 1.00A 3axzA-3ab1A:
undetectable		 3axzA-3ab1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 11 ALA A  73
LEU A  76
ILE A  27
PRO A  24
GLY A  50
 None
None
None
FAD  A 361 (-3.8A)
None
 1.28A 3bpxA-3ab1A:
undetectable
3bpxB-3ab1A:
undetectable		 3bpxA-3ab1A:
18.07
3bpxB-3ab1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 268
THR A 110
VAL A 123
ILE A 125
THR A  18
 FAD  A 361 (-4.5A)
None
None
None
None
 1.05A 3c6gA-3ab1A:
undetectable		 3c6gA-3ab1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 ALA A  66
LEU A 313
SER A  79
LEU A  53
ILE A  62
 None
None
None
FAD  A 361 (-4.8A)
FAD  A 361 ( 4.1A)
 0.88A 3drcA-3ab1A:
2.1		 3drcA-3ab1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		4 / 4 GLY A 106
TYR A 326
GLY A 292
ASP A 291
 None
 1.34A 3kl3A-3ab1A:
undetectable		 3kl3A-3ab1A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		4 / 7 LEU A 256
ALA A 175
VAL A 208
ILE A 168
 None
 0.97A 3wsjB-3ab1A:
undetectable		 3wsjB-3ab1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 11 GLY A 171
ALA A 175
ILE A 168
LEU A 137
ILE A 257
 None
 1.07A 4dt8A-3ab1A:
undetectable		 4dt8A-3ab1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 11 GLU A  44
LEU A  53
ASP A 298
LEU A 129
GLY A 128
 FAD  A 361 (-2.7A)
FAD  A 361 (-4.8A)
FAD  A 361 (-2.8A)
None
FAD  A 361 (-3.2A)
 1.41A 4foxC-3ab1A:
undetectable		 4foxC-3ab1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		5 / 12 GLY A  22
GLY A  26
ILE A  74
GLY A  51
GLY A  50
 FAD  A 361 ( 4.7A)
None
None
FAD  A 361 (-3.0A)
None
 1.02A 4yvgA-3ab1A:
undetectable		 4yvgA-3ab1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3ab1 FERREDOXIN--NADP
REDUCTASE
(Chlorobaculum
tepidum) 		4 / 8 ALA A 279
GLY A 128
ALA A 295
GLU A 315
 None
FAD  A 361 (-3.2A)
None
None
 0.81A 6mdqA-3ab1A:
undetectable		 6mdqA-3ab1A:
13.84