SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ab7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 11 ILE A 257
ASN A 259
ASP A 124
GLY A 125
PHE A 126
 ILE  A 257 ( 0.6A)
ASN  A 259 ( 0.6A)
ASP  A 124 ( 0.6A)
GLY  A 125 ( 0.0A)
PHE  A 126 ( 1.3A)
 1.34A 1hvyC-3ab7A:
undetectable		 1hvyC-3ab7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 11 LEU A 137
ALA A 170
VAL A 136
LEU A 113
ARG A 117
 LEU  A 137 ( 0.6A)
ALA  A 170 ( 0.0A)
VAL  A 136 ( 0.6A)
LEU  A 113 ( 0.6A)
ARG  A 117 ( 0.6A)
 1.43A 1kt6A-3ab7A:
undetectable		 1kt6A-3ab7A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 ALA A 167
ALA A 170
LEU A  19
GLY A 160
LEU A 237
 ALA  A 167 ( 0.0A)
ALA  A 170 ( 0.0A)
LEU  A  19 ( 0.6A)
GLY  A 160 ( 0.0A)
LEU  A 237 ( 0.6A)
 1.18A 1qabF-3ab7A:
undetectable		 1qabF-3ab7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.09A 2bm9A-3ab7A:
2.8		 2bm9A-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.17A 2bm9D-3ab7A:
2.5		 2bm9D-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.11A 2br4C-3ab7A:
2.2		 2br4C-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.12A 2br4D-3ab7A:
2.2		 2br4D-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.09A 2br4E-3ab7A:
2.2		 2br4E-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.10A 2br4F-3ab7A:
2.3		 2br4F-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 208
VAL A 213
GLY A 212
LEU A 171
ALA A 175
 LEU  A 208 ( 0.6A)
VAL  A 213 ( 0.6A)
GLY  A 212 ( 0.0A)
LEU  A 171 ( 0.6A)
ALA  A 175 ( 0.0A)
 0.88A 2egvA-3ab7A:
3.0		 2egvA-3ab7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 LEU A 208
VAL A 213
GLY A 212
LEU A 171
ALA A 175
 LEU  A 208 ( 0.6A)
VAL  A 213 ( 0.6A)
GLY  A 212 ( 0.0A)
LEU  A 171 ( 0.6A)
ALA  A 175 ( 0.0A)
 0.91A 2egvB-3ab7A:
2.5		 2egvB-3ab7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 THR A 266
ALA A  13
THR A   7
ALA A   6
ALA A 133
 THR  A 266 ( 0.8A)
ALA  A  13 ( 0.0A)
THR  A   7 ( 0.8A)
ALA  A   6 ( 0.0A)
ALA  A 133 ( 0.0A)
 1.02A 2gluB-3ab7A:
3.2		 2gluB-3ab7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 10 LEU A 208
VAL A 213
GLY A 212
LEU A 171
ALA A 175
 LEU  A 208 ( 0.6A)
VAL  A 213 ( 0.6A)
GLY  A 212 ( 0.0A)
LEU  A 171 ( 0.6A)
ALA  A 175 ( 0.0A)
 0.98A 2v3kA-3ab7A:
undetectable		 2v3kA-3ab7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		4 / 7 LEU A  23
LEU A  27
LEU A 145
PRO A 176
 LEU  A  23 ( 0.6A)
LEU  A  27 ( 0.6A)
LEU  A 145 ( 0.6A)
PRO  A 176 ( 1.1A)
 0.80A 2vq5B-3ab7A:
undetectable		 2vq5B-3ab7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		4 / 6 ALA A 147
LEU A 146
ALA A 133
THR A 132
 ALA  A 147 ( 0.0A)
LEU  A 146 ( 0.6A)
ALA  A 133 ( 0.0A)
THR  A 132 ( 0.8A)
 0.90A 3b6hA-3ab7A:
undetectable		 3b6hA-3ab7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		4 / 6 ALA A 147
LEU A 146
ALA A 133
THR A 132
 ALA  A 147 ( 0.0A)
LEU  A 146 ( 0.6A)
ALA  A 133 ( 0.0A)
THR  A 132 ( 0.8A)
 0.92A 3b6hB-3ab7A:
undetectable		 3b6hB-3ab7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		4 / 8 ALA A  16
LEU A 115
ASP A   8
SER A  10
 ALA  A  16 ( 0.0A)
LEU  A 115 ( 0.6A)
ASP  A   8 ( 0.6A)
SER  A  10 ( 0.0A)
 1.01A 3qj7A-3ab7A:
undetectable
3qj7D-3ab7A:
undetectable		 3qj7A-3ab7A:
27.16
3qj7D-3ab7A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		3 / 3 PHE A 126
ASP A 124
ARG A 258
 PHE  A 126 ( 1.3A)
ASP  A 124 ( 0.6A)
ARG  A 258 ( 0.6A)
 0.80A 4eahF-3ab7A:
undetectable		 4eahF-3ab7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		3 / 3 PHE A 126
ASP A 124
ARG A 258
 PHE  A 126 ( 1.3A)
ASP  A 124 ( 0.6A)
ARG  A 258 ( 0.6A)
 0.80A 4eahG-3ab7A:
undetectable		 4eahG-3ab7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 12 ALA A   6
LEU A   4
ILE A   3
LEU A 137
ILE A 103
 ALA  A   6 ( 0.0A)
LEU  A   4 ( 0.6A)
ILE  A   3 ( 0.7A)
LEU  A 137 ( 0.6A)
ILE  A 103 ( 0.7A)
 1.05A 5m24A-3ab7A:
undetectable		 5m24A-3ab7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 11 LEU A 115
GLY A  15
LEU A 113
THR A   7
ALA A   6
 LEU  A 115 ( 0.6A)
GLY  A  15 ( 0.0A)
LEU  A 113 ( 0.6A)
THR  A   7 ( 0.8A)
ALA  A   6 ( 0.0A)
 1.03A 5o96G-3ab7A:
undetectable		 5o96G-3ab7A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 10 LEU A 115
GLY A  15
LEU A 113
THR A   7
ALA A   6
 LEU  A 115 ( 0.6A)
GLY  A  15 ( 0.0A)
LEU  A 113 ( 0.6A)
THR  A   7 ( 0.8A)
ALA  A   6 ( 0.0A)
 1.08A 5o96G-3ab7A:
undetectable
5o96H-3ab7A:
2.0		 5o96G-3ab7A:
26.04
5o96H-3ab7A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 10 ARG A 179
ALA A 239
LEU A 208
VAL A 185
GLY A 184
 ARG  A 179 ( 0.6A)
ALA  A 239 ( 0.0A)
LEU  A 208 ( 0.6A)
VAL  A 185 ( 0.6A)
GLY  A 184 ( 0.0A)
 1.24A 5zbdA-3ab7A:
2.6		 5zbdA-3ab7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		5 / 10 ARG A 179
ALA A 239
LEU A 208
VAL A 185
GLY A 184
 ARG  A 179 ( 0.6A)
ALA  A 239 ( 0.0A)
LEU  A 208 ( 0.6A)
VAL  A 185 ( 0.6A)
GLY  A 184 ( 0.0A)
 1.23A 5zbdB-3ab7A:
undetectable		 5zbdB-3ab7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		3 / 3 GLU A 101
LEU A 104
ARG A 108
 GLU  A 101 ( 0.6A)
LEU  A 104 ( 0.6A)
ARG  A 108 ( 0.6A)
 0.66A 6d8fA-3ab7A:
2.7		 6d8fA-3ab7A:
17.56