SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3abb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 4 HIS A 245
LEU A 128
LEU A 132
LEU A 145
 None
 1.24A 1a4lD-3abbA:
undetectable		 1a4lD-3abbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 5 LEU A 125
GLU A 364
ALA A 366
LEU A 128
 None
 1.20A 1eta1-3abbA:
undetectable		 1eta1-3abbA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.30A 1hrkB-3abbA:
undetectable		 1hrkB-3abbA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 215
LEU A 214
SER A 112
VAL A 203
LEU A 228
 None
 1.22A 1ie9A-3abbA:
undetectable		 1ie9A-3abbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 GLU A 362
LEU A 358
LEU A 162
GLY A 163
 HEM  A1430 ( 4.7A)
HEM  A1430 ( 4.8A)
None
None
 0.90A 1mt1H-3abbA:
undetectable
1mt1K-3abbA:
undetectable		 1mt1H-3abbA:
15.02
1mt1K-3abbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		6 / 11 LEU A 145
PHE A 149
GLY A 255
VAL A 279
LEU A 283
LEU A 377
 None
 1.42A 1mx1A-3abbA:
undetectable		 1mx1A-3abbA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 256
GLY A 368
GLY A 369
LEU A 133
LEU A 128
 None
 1.03A 1ya4A-3abbA:
undetectable		 1ya4A-3abbA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 GLY A 369
GLY A 368
VAL A 279
LEU A 377
LEU A 283
 None
 1.28A 1ya4B-3abbA:
undetectable		 1ya4B-3abbA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 5 LEU A 161
PRO A 154
ALA A 157
ILE A 158
 None
 1.01A 2aofB-3abbA:
undetectable		 2aofB-3abbA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 LYS A  11
ASP A 312
ASP A 300
 None
 0.86A 2br4A-3abbA:
undetectable		 2br4A-3abbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.23A 2f78A-3abbA:
undetectable		 2f78A-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.22A 2f78B-3abbA:
undetectable		 2f78B-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.25A 2f7aA-3abbA:
undetectable		 2f7aA-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.24A 2f7aB-3abbA:
undetectable		 2f7aB-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.19A 2po5A-3abbA:
undetectable		 2po5A-3abbA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.22A 2po7A-3abbA:
undetectable		 2po7A-3abbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.23A 2po7B-3abbA:
undetectable		 2po7B-3abbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ARG A 285
ASN A 250
THR A 258
 None
 0.83A 2q63A-3abbA:
undetectable		 2q63A-3abbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 243
THR A 248
PHE A 172
GLY A 355
LEU A 214
 HEM  A1430 (-3.5A)
HEM  A1430 (-3.8A)
None
HEM  A1430 (-3.5A)
None
 1.40A 3aobC-3abbA:
undetectable		 3aobC-3abbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.30A 3aqiB-3abbA:
undetectable		 3aqiB-3abbA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 243
THR A 247
CYH A 353
 HEM  A1430 (-3.5A)
HEM  A1430 (-4.0A)
HEM  A1430 (-2.3A)
 0.55A 3e4eA-3abbA:
30.9		 3e4eA-3abbA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 243
THR A 247
CYH A 353
 HEM  A1430 (-3.5A)
HEM  A1430 (-4.0A)
HEM  A1430 (-2.3A)
 0.48A 3e4eB-3abbA:
30.9		 3e4eB-3abbA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 GLY A 396
THR A 258
GLU A 246
GLU A 362
 None
None
None
HEM  A1430 ( 4.7A)
 1.05A 3fpjA-3abbA:
undetectable		 3fpjA-3abbA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 316
LEU A  68
SER A  37
VAL A 314
ILE A 301
 None
 0.98A 3frqA-3abbA:
undetectable		 3frqA-3abbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 316
LEU A  68
SER A  37
VAL A 314
ILE A 301
 None
 1.01A 3frqB-3abbA:
0.8		 3frqB-3abbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 THR A 258
LEU A 254
VAL A 289
THR A 319
 None
 0.95A 3fwiA-3abbA:
38.0		 3fwiA-3abbA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 ILE A 388
TYR A  24
GLY A 255
ALA A 256
LEU A 379
 None
 1.03A 3hs6B-3abbA:
0.0		 3hs6B-3abbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.28A 3w1wA-3abbA:
undetectable		 3w1wA-3abbA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 ILE A 388
TYR A  24
GLY A 255
ALA A 256
LEU A 379
 None
 1.09A 4e1gB-3abbA:
1.9		 4e1gB-3abbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 THR A 247
LEU A 367
GLN A 126
LEU A 125
 HEM  A1430 (-4.0A)
None
None
None
 1.10A 4nc3A-3abbA:
undetectable		 4nc3A-3abbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 359
GLN A 352
GLY A 349
 HEM  A1430 (-3.6A)
None
None
 0.61A 4odoC-3abbA:
undetectable		 4odoC-3abbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 129
ILE A 252
GLY A 255
VAL A 279
LEU A 269
 None
 1.01A 4y8wA-3abbA:
34.5		 4y8wA-3abbA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 129
ILE A 252
GLY A 255
VAL A 279
LEU A 269
 None
 1.05A 4y8wB-3abbA:
34.6		 4y8wB-3abbA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 129
ILE A 252
GLY A 255
VAL A 279
LEU A 269
 None
 1.00A 4y8wC-3abbA:
34.4		 4y8wC-3abbA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 LEU A 363
LEU A 367
THR A 258
THR A 287
 None
 0.93A 4z90A-3abbA:
undetectable
4z90B-3abbA:
1.5
4z90C-3abbA:
undetectable
4z90D-3abbA:
undetectable
4z90E-3abbA:
undetectable		 4z90A-3abbA:
23.34
4z90B-3abbA:
23.34
4z90C-3abbA:
23.34
4z90D-3abbA:
23.34
4z90E-3abbA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ASP A 189
ASN A 178
PHE A 172
 None
 0.71A 5dsgB-3abbA:
1.2		 5dsgB-3abbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 ARG A 124
GLU A 160
GLY A 213
ASP A 212
 None
 1.06A 5kgpA-3abbA:
undetectable		 5kgpA-3abbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 ARG A 124
GLU A 160
GLY A 213
ASP A 212
 None
 1.07A 5kgpB-3abbA:
undetectable		 5kgpB-3abbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 ASN A 357
PHE A 113
THR A 248
GLY A 244
 None
None
HEM  A1430 (-3.8A)
HEM  A1430 (-3.2A)
 0.99A 5nzxA-3abbA:
undetectable		 5nzxA-3abbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3abb CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 LEU A 109
LEU A 354
ILE A 158
LEU A 215
ALA A 243
 None
HEM  A1430 ( 4.5A)
None
None
HEM  A1430 (-3.5A)
 1.39A 5og9A-3abbA:
31.4		 5og9A-3abbA:
24.19