SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3abs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		5 / 12 PRO B 230
SER B 235
VAL B 106
GLY B 168
GLY B 227
 None
 0.89A 1uakA-3absB:
undetectable		 1uakA-3absB:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 5 SER B 289
GLU B 210
TYR B 241
ASP B 255
 None
 1.42A 1vidA-3absB:
undetectable		 1vidA-3absB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 5 LEU B 225
PRO B 199
VAL B 163
ILE B 165
 None
 1.01A 2aoiB-3absB:
undetectable		 2aoiB-3absB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 6 SER B 289
GLU B 210
TYR B 241
ASP B 255
 None
 1.40A 2cl5B-3absB:
undetectable		 2cl5B-3absB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 6 SER B 289
GLU B 210
TYR B 241
ASP B 255
 None
 1.40A 2zvjA-3absB:
undetectable		 2zvjA-3absB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		3 / 3 ILE B 174
SER B 239
SER B 237
 None
 0.61A 3iltH-3absB:
undetectable		 3iltH-3absB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		5 / 10 VAL B 226
LEU B 224
SER B 239
GLY B 168
GLY B 205
 None
 0.99A 3ls4H-3absB:
undetectable		 3ls4H-3absB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 8 LEU B 182
ALA B 274
GLY B 197
PRO B 199
 None
 0.95A 3ny4A-3absB:
undetectable		 3ny4A-3absB:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 7 ASN B 177
GLU B 180
GLU B 179
TYR B 178
 None
 1.35A 4r87I-3absB:
undetectable		 4r87I-3absB:
21.83