SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3abz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 TRP A 226
VAL A  25
TRP A  28
 GOL  A5001 (-3.5A)
None
None
 0.91A 1c4dA-3abzA:
undetectable
1c4dB-3abzA:
undetectable		 1c4dA-3abzA:
4.50
1c4dB-3abzA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 6 LEU A 463
VAL A 437
SER A 440
GLN A 551
 None
GOL  A5002 (-3.3A)
None
None
 0.86A 1e7aB-3abzA:
undetectable		 1e7aB-3abzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 6 LEU A 208
GLU A 199
THR A 231
ALA A 235
 None
 1.20A 1etb2-3abzA:
undetectable		 1etb2-3abzA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 6 LYS A 206
VAL A 149
ILE A 211
ARG A 167
 None
 1.02A 1iepA-3abzA:
undetectable		 1iepA-3abzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 4 SER A  61
LEU A 313
TYR A 362
GLY A  49
 None
 1.29A 1liiA-3abzA:
4.0		 1liiA-3abzA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 9 GLY A 355
GLU A 588
GLY A 585
GLY A 112
GLY A 114
 None
 1.18A 1mxdA-3abzA:
1.2		 1mxdA-3abzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QYX_A_ASDA500_1
(ESTRADIOL 17
BETA-DEHYDROGENASE 1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 9 VAL A 529
LEU A 413
SER A 440
PHE A 487
VAL A 442
 None
None
None
None
GOL  A5002 ( 3.8A)
 1.44A 1qyxA-3abzA:
0.9		 1qyxA-3abzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 SER A 398
TYR A 475
GLY A 553
LEU A 394
PHE A 487
 None
 1.19A 1vpoH-3abzA:
5.0
1vpoL-3abzA:
4.8		 1vpoH-3abzA:
12.85
1vpoL-3abzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 10 GLY A 392
GLY A 553
GLU A 396
SER A 440
PHE A 487
 None
 1.20A 1w76B-3abzA:
undetectable		 1w76B-3abzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 SER A 117
ASP A 152
LEU A 169
LEU A 174
 None
 0.94A 2bfpB-3abzA:
undetectable		 2bfpB-3abzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 ALA A  95
GLY A  46
SER A  61
 None
 0.56A 2ivuA-3abzA:
undetectable		 2ivuA-3abzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 TYR A 643
GLY A  69
PHE A 115
 None
 0.71A 2m2pB-3abzA:
undetectable		 2m2pB-3abzA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 ASN A  66
GLY A 624
THR A 625
SER A  72
 None
 1.00A 2o5yH-3abzA:
3.6
2o5yL-3abzA:
4.8		 2o5yH-3abzA:
14.16
2o5yL-3abzA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 ASN A  66
GLY A 624
THR A 625
SER A 667
 None
 1.22A 2o5yH-3abzA:
3.6
2o5yL-3abzA:
4.8		 2o5yH-3abzA:
14.16
2o5yL-3abzA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 ALA A  71
GLY A  69
GLY A  67
ASN A  66
GLY A 624
 None
 0.93A 2pkmA-3abzA:
3.8		 2pkmA-3abzA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 VAL A 529
TYR A 467
VAL A 554
SER A 440
 None
 1.14A 2x45A-3abzA:
undetectable		 2x45A-3abzA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 4 VAL A 529
TYR A 467
VAL A 554
SER A 440
 None
 1.14A 2x45B-3abzA:
undetectable		 2x45B-3abzA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 VAL A 529
TYR A 467
VAL A 554
SER A 440
 None
 1.15A 2x45C-3abzA:
undetectable		 2x45C-3abzA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 4 ARG A 113
GLY A 111
GLU A 154
SER A 667
 None
 1.21A 2xctS-3abzA:
undetectable
2xctU-3abzA:
undetectable		 2xctS-3abzA:
23.02
2xctU-3abzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 ILE A 172
ILE A 696
GLY A 693
VAL A 690
ASP A 695
 None
 1.07A 2yvlB-3abzA:
undetectable		 2yvlB-3abzA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 SER A 419
PRO A 421
PRO A 431
PHE A 432
PHE A 460
 None
 0.88A 2zifA-3abzA:
undetectable		 2zifA-3abzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 TYR A 193
ARG A 157
GLU A 590
SER A 356
 None
None
GOL  A5001 ( 4.6A)
GOL  A5001 (-3.5A)
 1.24A 2zt7A-3abzA:
undetectable		 2zt7A-3abzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 LEU A 579
VAL A 383
GLY A 384
THR A 603
ILE A 581
 None
 1.23A 3bf1A-3abzA:
undetectable
3bf1B-3abzA:
undetectable		 3bf1A-3abzA:
16.06
3bf1B-3abzA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 ASP A  26
PHE A 244
SER A  44
 None
 0.96A 3i5uB-3abzA:
3.4		 3i5uB-3abzA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 PHE A 118
GLY A 100
PHE A  74
PHE A 777
 None
 1.09A 3ko0B-3abzA:
undetectable
3ko0J-3abzA:
undetectable		 3ko0B-3abzA:
9.16
3ko0J-3abzA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 GLY A 100
PHE A  74
PHE A 777
PHE A 118
 None
 1.10A 3ko0L-3abzA:
undetectable
3ko0N-3abzA:
undetectable		 3ko0L-3abzA:
9.16
3ko0N-3abzA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 PHE A 118
GLY A 100
PHE A  74
PHE A 777
 None
 1.09A 3ko0K-3abzA:
undetectable
3ko0S-3abzA:
undetectable		 3ko0K-3abzA:
9.16
3ko0S-3abzA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 PHE A 118
GLY A 100
PHE A  74
PHE A 777
 None
 1.07A 3ko0R-3abzA:
undetectable
3ko0T-3abzA:
undetectable		 3ko0R-3abzA:
9.16
3ko0T-3abzA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 10 ASN A 650
VAL A 365
TYR A 368
GLY A 649
LEU A 375
 None
 1.36A 3lp1A-3abzA:
undetectable		 3lp1A-3abzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 LYS A 206
VAL A 149
ILE A 211
ARG A 167
 None
 1.06A 3mssB-3abzA:
undetectable		 3mssB-3abzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 ARG A 178
VAL A 145
THR A 129
 None
 0.80A 3ndtA-3abzA:
undetectable		 3ndtA-3abzA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 LYS A 280
ARG A 276
ASP A 214
 None
 1.42A 3o7wA-3abzA:
undetectable		 3o7wA-3abzA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 ASN A 194
ASP A 593
THR A 625
SER A 162
 None
 1.27A 3p2kC-3abzA:
undetectable		 3p2kC-3abzA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 11 TYR A 475
ILE A 476
PHE A 477
THR A 382
GLU A 563
 None
 1.43A 3qelA-3abzA:
4.5
3qelB-3abzA:
4.9		 3qelA-3abzA:
18.71
3qelB-3abzA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 TYR A 841
GLU A 839
GLU A 813
TYR A 802
 None
 1.12A 3rqwC-3abzA:
3.1
3rqwD-3abzA:
3.1		 3rqwC-3abzA:
17.65
3rqwD-3abzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 GLU A 839
GLU A 813
TYR A 802
TYR A 841
 None
 1.14A 3rqwF-3abzA:
2.8
3rqwJ-3abzA:
2.3		 3rqwF-3abzA:
17.65
3rqwJ-3abzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 7 LEU A  13
GLU A  17
LEU A   9
PRO A  39
ILE A  38
 None
 1.45A 3s56B-3abzA:
undetectable		 3s56B-3abzA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 TYR A 692
GLU A 120
TYR A 700
PRO A 626
 None
 1.32A 3ugrA-3abzA:
3.5		 3ugrA-3abzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 6 VAL A 149
LEU A 207
ILE A 211
VAL A 164
 None
 0.76A 4a9kA-3abzA:
undetectable		 4a9kA-3abzA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 ASN A  66
GLN A 106
ASN A 104
THR A 103
 None
 1.32A 4d1yA-3abzA:
3.5
4d1yB-3abzA:
3.5		 4d1yA-3abzA:
12.34
4d1yB-3abzA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 GLU A 175
GLU A 171
GLY A 844
ARG A 178
 None
 0.87A 4fgzA-3abzA:
undetectable		 4fgzA-3abzA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 ALA A 637
LEU A 323
TYR A 720
LEU A 331
 None
 0.91A 4jjkA-3abzA:
undetectable		 4jjkA-3abzA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 9 GLY A 355
SER A 358
SER A 352
GLY A 354
THR A 589
 None
 1.42A 4lb0A-3abzA:
undetectable		 4lb0A-3abzA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 VAL A 442
LEU A 463
VAL A 531
PHE A 550
 GOL  A5002 ( 3.8A)
None
None
None
 1.05A 4lb0B-3abzA:
undetectable		 4lb0B-3abzA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 VAL A 133
PRO A 101
THR A 102
GLU A 116
GLY A 114
 None
 1.32A 4q15B-3abzA:
undetectable		 4q15B-3abzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 ALA A 346
ILE A 558
THR A 603
VAL A 607
 None
 0.86A 4r20A-3abzA:
undetectable		 4r20A-3abzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 9 ALA A 385
ASN A 621
ILE A 619
VAL A 620
GLY A 582
 None
 1.16A 4r20B-3abzA:
undetectable		 4r20B-3abzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 GLU A 839
GLU A 813
TYR A 802
TYR A 841
 None
 1.15A 4twdA-3abzA:
3.1
4twdE-3abzA:
3.0		 4twdA-3abzA:
16.81
4twdE-3abzA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 TYR A 841
GLU A 839
GLU A 813
TYR A 802
 None
 1.12A 4twdA-3abzA:
3.1
4twdB-3abzA:
3.1		 4twdA-3abzA:
16.81
4twdB-3abzA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 GLU A 839
GLU A 813
TYR A 802
TYR A 841
 None
 1.14A 4twdF-3abzA:
2.3
4twdJ-3abzA:
2.3		 4twdF-3abzA:
16.81
4twdJ-3abzA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 6 TYR A 841
GLU A 839
GLU A 813
TYR A 802
 None
 1.15A 4twdG-3abzA:
2.3
4twdH-3abzA:
2.5		 4twdG-3abzA:
16.81
4twdH-3abzA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 TYR A 841
GLU A 839
GLU A 813
TYR A 802
 None
 1.16A 4twdH-3abzA:
2.5
4twdI-3abzA:
2.3		 4twdH-3abzA:
16.81
4twdI-3abzA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 GLU A  17
LYS A  18
LEU A  21
ARG A 276
 None
 0.70A 4wg0B-3abzA:
undetectable
4wg0C-3abzA:
undetectable		 4wg0B-3abzA:
1.63
4wg0C-3abzA:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		3 / 3 LEU A  21
VAL A 271
ASP A 272
 None
 0.61A 4y8wC-3abzA:
undetectable		 4y8wC-3abzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 VAL A 468
TYR A 381
ILE A 371
THR A 350
 None
 1.19A 4ze1A-3abzA:
undetectable		 4ze1A-3abzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 THR A  30
LEU A  99
MET A 281
THR A 144
 None
GOL  A5001 ( 3.9A)
None
None
 1.04A 5e4dA-3abzA:
undetectable
5e4dB-3abzA:
undetectable		 5e4dA-3abzA:
13.39
5e4dB-3abzA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 TYR A 475
ILE A 476
PHE A 477
THR A 382
GLU A 563
 None
 1.41A 5ewjC-3abzA:
4.3
5ewjD-3abzA:
4.9		 5ewjC-3abzA:
18.64
5ewjD-3abzA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 ASP A  26
HIS A  29
SER A  23
ILE A 242
MET A 221
 None
 1.06A 5igwA-3abzA:
1.6		 5igwA-3abzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 GLY A 370
VAL A 578
ILE A 339
VAL A 341
 None
 0.80A 5ik1A-3abzA:
undetectable		 5ik1A-3abzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 ILE A 321
PRO A 662
LEU A 656
LEU A 331
VAL A 618
 None
 1.17A 5im2A-3abzA:
undetectable		 5im2A-3abzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		6 / 12 ASP A  45
ARG A 113
LYS A 146
HIS A 147
MET A 190
GLU A 590
 GOL  A5001 (-3.1A)
None
GOL  A5001 (-2.9A)
None
GOL  A5001 (-3.8A)
GOL  A5001 ( 4.6A)
 0.43A 5m6gA-3abzA:
34.6		 5m6gA-3abzA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 TYR A 482
THR A 512
ARG A 515
GLN A 497
 None
 1.37A 5tzoB-3abzA:
undetectable		 5tzoB-3abzA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 ARG A  51
ASP A  45
LEU A  99
SER A 224
 GOL  A5001 ( 4.7A)
GOL  A5001 (-3.1A)
GOL  A5001 ( 3.9A)
None
 1.25A 5uxcA-3abzA:
undetectable		 5uxcA-3abzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 12 MET A 221
GLN A 277
GLU A   7
ILE A 282
ASP A   5
 None
 1.27A 5vlmG-3abzA:
undetectable		 5vlmG-3abzA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 VAL A 322
VAL A 755
GLY A 715
TYR A 716
 None
None
None
GOL  A5003 (-4.3A)
 0.99A 5x80C-3abzA:
undetectable
5x80D-3abzA:
undetectable		 5x80C-3abzA:
11.74
5x80D-3abzA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 10 LEU A 656
LEU A 375
ILE A 652
PRO A 367
GLY A 649
 None
 1.17A 6dm0B-3abzA:
3.8
6dm0C-3abzA:
4.5		 6dm0B-3abzA:
6.93
6dm0C-3abzA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 5 PHE A 148
VAL A 133
PRO A 176
VAL A 149
 None
 0.79A 6ekzA-3abzA:
undetectable		 6ekzA-3abzA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 8 VAL A 481
TYR A 533
HIS A 443
GLU A 586
 None
 1.05A 6gneB-3abzA:
3.2		 6gneB-3abzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 6 ILE A  50
ALA A  96
ARG A  42
ASP A  26
 None
 1.06A 6hu9m-3abzA:
1.6
6hu9q-3abzA:
undetectable		 6hu9m-3abzA:
20.05
6hu9q-3abzA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		4 / 7 GLY A 511
TYR A 482
GLU A 544
GLY A 546
 None
 0.88A 6n7fA-3abzA:
undetectable		 6n7fA-3abzA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 10 ASN A 677
LEU A 674
ASP A 593
LEU A 153
GLY A 111
 None
 1.37A 6r2eB-3abzA:
undetectable		 6r2eB-3abzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 10 ASN A 677
LEU A 674
ASP A 593
LEU A 153
GLY A 111
 None
 1.39A 6r2eC-3abzA:
undetectable		 6r2eC-3abzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 10 ASN A 677
LEU A 674
ASP A 593
LEU A 153
GLY A 111
 None
 1.30A 6r2eD-3abzA:
undetectable		 6r2eD-3abzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 11 ASN A 677
LEU A 674
ASP A 593
LEU A 153
GLY A 111
 None
 1.35A 6r2eF-3abzA:
undetectable		 6r2eF-3abzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3abz BETA-GLUCOSIDASE I
(Kluyveromyces
marxianus) 		5 / 11 ASN A 677
LEU A 674
ASP A 593
LEU A 153
GLY A 111
 None
 1.36A 6r2eG-3abzA:
undetectable		 6r2eG-3abzA:
16.83