SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3acc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 12 MET A  52
LEU A  55
TYR A  34
GLY A  27
LEU A  63
 None
None
DIO  A 991 (-3.8A)
None
None
 0.91A 1pj7A-3accA:
undetectable		 1pj7A-3accA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 7 TYR A  73
GLN A 139
TYR A 113
ILE A  70
 None
 1.26A 2ph9A-3accA:
undetectable
2ph9B-3accA:
undetectable		 2ph9A-3accA:
22.69
2ph9B-3accA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 7 ARG A  32
LEU A  55
ARG A 127
ILE A 144
 None
None
DIO  A 991 (-3.2A)
None
 1.09A 3ln1C-3accA:
undetectable		 3ln1C-3accA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 5 ARG A  32
LEU A  55
ARG A 127
ILE A 144
 None
None
DIO  A 991 (-3.2A)
None
 1.11A 3ln1D-3accA:
undetectable		 3ln1D-3accA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 12 PHE A 149
LEU A 132
ILE A  99
PHE A  51
TYR A 159
 None
 1.44A 5dlvA-3accA:
undetectable		 5dlvA-3accA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 4 ASP A 162
GLY A  47
ASP A 103
ASP A 106
 5GP  A 817 (-4.6A)
None
5GP  A 817 (-3.0A)
5GP  A 817 (-4.2A)
 1.16A 5e72A-3accA:
undetectable		 5e72A-3accA:
22.65