SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3acp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 5 THR A   4
THR A 353
HIS A   9
LEU A  36
 None
 1.35A 1d4fC-3acpA:
undetectable		 1d4fC-3acpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 144
VAL A  99
ASP A 100
ILE A 110
 None
 1.01A 1p7rA-3acpA:
undetectable		 1p7rA-3acpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 135
VAL A 193
VAL A 181
LEU A 174
THR A 173
 None
 0.91A 1z9yA-3acpA:
undetectable		 1z9yA-3acpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 12 ARG A  72
ALA A   8
ASP A  77
PHE A 372
PHE A 377
 None
 1.21A 2ejtA-3acpA:
undetectable		 2ejtA-3acpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 297
TYR A 339
ASN A 298
ASP A 236
 None
 1.06A 2g72B-3acpA:
undetectable		 2g72B-3acpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 406
ASP A  33
ILE A  39
ASP A 382
HIS A   9
 None
 1.48A 2qmjA-3acpA:
undetectable		 2qmjA-3acpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 4 SER A 349
GLY A 350
GLY A 310
GLY A 332
 None
 0.77A 3bogB-3acpA:
undetectable
3bogD-3acpA:
undetectable		 3bogB-3acpA:
undetectable
3bogD-3acpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 330
VAL A  32
VAL A 347
LEU A 312
ILE A 355
 None
 1.20A 3elzC-3acpA:
2.3		 3elzC-3acpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  46
PHE A  61
VAL A 379
ILE A  10
GLN A  11
 None
 1.38A 3elzC-3acpA:
2.3		 3elzC-3acpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 347
LEU A 401
ILE A 370
ILE A 355
 None
 0.88A 3gcsA-3acpA:
undetectable		 3gcsA-3acpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		3 / 3 LYS A   1
ILE A 355
PHE A 346
 None
 0.79A 3j7zS-3acpA:
undetectable
3j7za-3acpA:
undetectable		 3j7zS-3acpA:
15.23
3j7za-3acpA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 134
ILE A 139
ILE A 162
ILE A 110
ILE A 118
 None
 0.99A 3s43A-3acpA:
undetectable		 3s43A-3acpA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 134
ILE A 139
ILE A 162
ILE A 110
ILE A 118
 None
 0.98A 3s45A-3acpA:
undetectable		 3s45A-3acpA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 5 SER A 349
THR A 333
GLU A 384
ASP A  95
 None
 1.42A 3tm4A-3acpA:
undetectable		 3tm4A-3acpA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 5 SER A 349
THR A 333
GLU A 384
ASP A  95
 None
 1.44A 3tm4B-3acpA:
undetectable		 3tm4B-3acpA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 156
ALA A  98
GLN A 387
SER A 386
 None
 1.15A 5km8A-3acpA:
undetectable
5km8B-3acpA:
undetectable		 5km8A-3acpA:
17.63
5km8B-3acpA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 8 SER A 195
THR A 201
SER A 197
THR A 212
 None
 0.99A 5l4eA-3acpA:
undetectable
5l4eB-3acpA:
undetectable
5l4eC-3acpA:
undetectable
5l4eD-3acpA:
undetectable
5l4eE-3acpA:
undetectable		 5l4eA-3acpA:
20.65
5l4eB-3acpA:
20.65
5l4eC-3acpA:
20.65
5l4eD-3acpA:
20.65
5l4eE-3acpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 8 THR A 212
SER A 195
THR A 201
SER A 197
 None
 0.96A 5l4eA-3acpA:
undetectable
5l4eB-3acpA:
undetectable
5l4eC-3acpA:
undetectable
5l4eD-3acpA:
undetectable
5l4eE-3acpA:
undetectable		 5l4eA-3acpA:
20.65
5l4eB-3acpA:
20.65
5l4eC-3acpA:
20.65
5l4eD-3acpA:
20.65
5l4eE-3acpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 377
ILE A  39
SER A 349
THR A 353
 None
 1.01A 5vkqA-3acpA:
undetectable
5vkqD-3acpA:
undetectable		 5vkqA-3acpA:
13.18
5vkqD-3acpA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 7 SER A 349
THR A 353
PHE A 377
ILE A  39
 None
 1.05A 5vkqA-3acpA:
undetectable
5vkqB-3acpA:
undetectable		 5vkqA-3acpA:
13.18
5vkqB-3acpA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 8 SER A 349
THR A 353
PHE A 377
ILE A  39
 None
 1.05A 5vkqB-3acpA:
undetectable
5vkqC-3acpA:
undetectable		 5vkqB-3acpA:
13.18
5vkqC-3acpA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		4 / 7 SER A 349
THR A 353
PHE A 377
ILE A  39
 None
 1.03A 5vkqC-3acpA:
undetectable
5vkqD-3acpA:
undetectable		 5vkqC-3acpA:
13.18
5vkqD-3acpA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 135
VAL A 193
VAL A 181
LEU A 174
THR A 173
 None
 0.98A 6bccA-3acpA:
undetectable		 6bccA-3acpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3acp WD REPEAT-CONTAINING
PROTEIN YGL004C
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 390
ALA A 344
LEU A 414
 None
 0.77A 6d9kF-3acpA:
undetectable		 6d9kF-3acpA:
20.45