SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3acz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 7 MET A 252
SER A  77
SER A  70
ILE A  71
 None
 1.05A 1fxhA-3aczA:
undetectable
1fxhB-3aczA:
undetectable		 1fxhA-3aczA:
17.63
1fxhB-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 8 MET A 252
SER A  77
SER A  70
ILE A  71
 None
 1.03A 1gm7A-3aczA:
undetectable
1gm7B-3aczA:
undetectable		 1gm7A-3aczA:
17.63
1gm7B-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 8 HIS A 276
LEU A 386
ALA A 385
LEU A 320
 None
 0.84A 1hwiB-3aczA:
undetectable		 1hwiB-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 9 HIS A 276
LEU A 386
ALA A 385
LEU A 320
LEU A 324
 None
 1.07A 1hwiA-3aczA:
undetectable		 1hwiA-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 8 HIS A 276
LEU A 386
ALA A 385
LEU A 320
 None
 0.84A 1hwiD-3aczA:
2.1		 1hwiD-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 8 HIS A 276
LEU A 386
ALA A 385
LEU A 320
 None
 0.83A 1hwiC-3aczA:
undetectable		 1hwiC-3aczA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 6 SER A  90
ILE A 229
ALA A 220
ALA A 196
 None
 0.95A 1w0gA-3aczA:
undetectable		 1w0gA-3aczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 10 SER A 218
ILE A 198
PHE A 115
THR A 131
ILE A 229
 None
 1.32A 2v0mA-3aczA:
undetectable		 2v0mA-3aczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A  79
GLY A 216
HIS A 201
LEU A 239
SER A 238
 None
 1.41A 3bxoB-3aczA:
undetectable		 3bxoB-3aczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 GLY A 195
ASP A 162
ILE A 163
ARG A 176
LEU A 177
 None
None
None
SO4  A2003 (-3.1A)
None
 1.35A 3iv6C-3aczA:
2.3		 3iv6C-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 GLY A 195
ASP A 162
ILE A 163
ARG A 176
LEU A 177
 None
None
None
SO4  A2003 (-3.1A)
None
 1.18A 3iv6D-3aczA:
2.4		 3iv6D-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 9 GLY A 195
ALA A 196
ASP A 197
ILE A 198
ILE A 166
 None
 0.81A 3ogpA-3aczA:
undetectable		 3ogpA-3aczA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 GLY A 195
ALA A 196
ASP A 197
ILE A 198
MET A 147
 None
 0.74A 3ogqB-3aczA:
undetectable		 3ogqB-3aczA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A 330
LEU A 339
LEU A 333
ARG A 367
ILE A 214
 None
None
LLP  A 205 ( 4.3A)
SO4  A2001 (-2.9A)
LLP  A 205 ( 4.5A)
 1.30A 3olsB-3aczA:
undetectable		 3olsB-3aczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		3 / 3 LYS A 190
PRO A 191
LEU A 192
 None
 0.85A 3tpxE-3aczA:
undetectable		 3tpxE-3aczA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 7 LEU A 189
ALA A 196
ASP A 197
ILE A 102
 None
 0.72A 4eyrA-3aczA:
undetectable		 4eyrA-3aczA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 6 ASP A 105
GLY A 360
PRO A 343
THR A 347
 None
None
None
SO4  A2001 (-4.0A)
 1.05A 4l1aB-3aczA:
undetectable		 4l1aB-3aczA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 5 ASN A 208
SER A 202
LEU A 333
ASN A 155
 None
LLP  A 205 ( 2.8A)
LLP  A 205 ( 4.3A)
SO4  A2001 (-3.3A)
 1.09A 4n09C-3aczA:
undetectable		 4n09C-3aczA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 LEU A 324
ILE A 368
LEU A 320
LEU A 386
ALA A 385
 None
 1.05A 4p65F-3aczA:
undetectable
4p65H-3aczA:
undetectable
4p65K-3aczA:
undetectable
4p65L-3aczA:
undetectable		 4p65F-3aczA:
7.20
4p65H-3aczA:
7.20
4p65K-3aczA:
7.73
4p65L-3aczA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 THR A 306
MET A 300
THR A 182
GLY A 302
ALA A 296
 None
None
LLP  A 205 ( 3.6A)
None
None
 1.22A 4ypmA-3aczA:
undetectable		 4ypmA-3aczA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 6 ARG A 173
GLU A 172
GLU A 135
VAL A 134
 None
 1.32A 5h4dA-3aczA:
2.7		 5h4dA-3aczA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 10 PRO A 191
ILE A 295
LEU A 189
SER A 152
GLU A 151
 None
None
None
None
LLP  A 205 ( 3.8A)
 1.40A 5tixB-3aczA:
undetectable		 5tixB-3aczA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A 181
GLY A 304
SER A 202
ALA A 199
TYR A 149
 None
None
LLP  A 205 ( 2.8A)
None
None
 1.12A 5zvgA-3aczA:
4.0		 5zvgA-3aczA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A 181
GLY A 304
SER A 202
ALA A 199
TYR A 149
 None
None
LLP  A 205 ( 2.8A)
None
None
 1.10A 5zvgB-3aczA:
3.9		 5zvgB-3aczA:
22.96