SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3adf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		4 / 6 TYR A  87
GLU A 144
ILE A 118
TYR A 116
 None
None
None
CRQ  A  64 ( 4.6A)
 1.06A 1maaB-3adfA:
undetectable
1maaD-3adfA:
undetectable		 1maaB-3adfA:
15.84
1maaD-3adfA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		4 / 4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.19A 1u18A-3adfA:
undetectable		 1u18A-3adfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		5 / 12 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CRQ  A  64 ( 4.0A)
CRQ  A  64 ( 3.8A)
None
None
None
 0.92A 2jfaB-3adfA:
undetectable		 2jfaB-3adfA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		5 / 11 ILE A 100
GLY A  99
TYR A  95
PHE A 125
GLY A 122
 None
 1.11A 2y7kA-3adfA:
undetectable		 2y7kA-3adfA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		4 / 7 GLU A 144
TYR A 177
HIS A  88
VAL A 183
 None
 0.94A 4a97D-3adfA:
undetectable		 4a97D-3adfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		4 / 6 GLU A 144
TYR A 177
HIS A  88
VAL A 183
 None
 0.99A 4a97E-3adfA:
undetectable		 4a97E-3adfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		4 / 7 GLU A 144
TYR A 177
HIS A  88
VAL A 183
 None
 1.02A 4a97H-3adfA:
undetectable		 4a97H-3adfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		3 / 3 LEU A  50
PRO A  51
ARG A 119
 None
 0.67A 4klrB-3adfA:
undetectable		 4klrB-3adfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		5 / 12 LEU A  42
ALA A 103
TYR A 116
ILE A  10
GLY A  31
 None
None
CRQ  A  64 ( 4.6A)
None
None
 1.35A 4l9qA-3adfA:
undetectable		 4l9qA-3adfA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		5 / 12 VAL A 157
ASP A 156
GLU A 144
LEU A 161
SER A 142
 None
None
None
None
CRQ  A  64 ( 2.8A)
 1.19A 5m5cB-3adfA:
undetectable		 5m5cB-3adfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		5 / 10 VAL A 157
ASP A 156
GLU A 144
LEU A 161
SER A 142
 None
None
None
None
CRQ  A  64 ( 2.8A)
 1.21A 5m5cE-3adfA:
undetectable		 5m5cE-3adfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		4 / 6 PHE A 125
PRO A 126
GLY A 129
ASN A 128
 None
 0.88A 5x24A-3adfA:
undetectable		 5x24A-3adfA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		5 / 10 ASN A  32
TYR A 116
THR A  37
GLY A  29
ASP A  41
 None
CRQ  A  64 ( 4.6A)
None
None
None
 1.21A 6mb7A-3adfA:
0.0		 6mb7A-3adfA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3adf MONOMERIC AZAMI
GREEN
(Galaxea
fascicularis) 		3 / 3 ARG A  66
PHE A  61
PHE A  68
 CRQ  A  64 ( 3.8A)
None
None
 1.08A 6nknC-3adfA:
undetectable
6nknJ-3adfA:
undetectable		 6nknC-3adfA:
17.47
6nknJ-3adfA:
14.04