SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aeb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 7 LEU B 152
GLU B 148
ARG B 189
ASP B 193
LEU B 129
 None
 1.33A 1n13D-3aebB:
undetectable
1n13E-3aebB:
undetectable		 1n13D-3aebB:
19.51
1n13E-3aebB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa;
Sus
scrofa) 		4 / 6 LYS D  35
ALA B 204
GLU B 201
GLU B 200
 None
 1.49A 1qhyA-3aebD:
undetectable		 1qhyA-3aebD:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 ALA B  84
LEU B 111
PHE B  61
ILE B  51
ILE B  49
 None
 0.90A 1rx7A-3aebB:
undetectable		 1rx7A-3aebB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 9 LEU B 203
LEU B 212
ALA B 187
LEU B 184
ALA B 234
 None
 0.98A 2vcvE-3aebB:
undetectable		 2vcvE-3aebB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 LEU D 106
GLY D  83
GLN D  86
ARG B 214
VAL D  49
 None
HEM  C1305 (-3.4A)
None
None
None
 1.28A 2w8yA-3aebD:
undetectable		 2w8yA-3aebD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		4 / 5 ASN D 120
PHE D 119
GLY D 115
TYR D 118
 None
 1.18A 3bcrA-3aebD:
undetectable		 3bcrA-3aebD:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 9 VAL B  96
LEU B  48
ILE B  99
ALA B  15
ALA B  47
 None
 1.12A 3mdvA-3aebB:
undetectable		 3mdvA-3aebB:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		6 / 8 PRO B 169
HIS B 216
ILE B 218
MET C  39
ILE C  43
ARG C  46
 F7A  C1201 (-4.6A)
F7A  C1201 ( 4.1A)
F3S  B 304 (-4.2A)
F7A  C1201 (-3.2A)
None
F7A  C1201 ( 3.2A)
 0.65A 3sfeB-3aebB:
36.7
3sfeC-3aebB:
undetectable		 3sfeB-3aebB:
99.60
3sfeC-3aebB:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		6 / 8 PRO B 169
ILE B 218
MET C  39
SER C  42
ILE C  43
ARG C  46
 F7A  C1201 (-4.6A)
F3S  B 304 (-4.2A)
F7A  C1201 (-3.2A)
F7A  C1201 (-3.1A)
None
F7A  C1201 ( 3.2A)
 0.92A 3sfeB-3aebB:
36.7
3sfeC-3aebB:
undetectable		 3sfeB-3aebB:
99.60
3sfeC-3aebB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa;
Sus
scrofa) 		4 / 5 LYS D 135
LEU D 136
LEU C  74
LYS C  78
 None
 1.09A 4k4yA-3aebD:
undetectable		 4k4yA-3aebD:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa;
Sus
scrofa) 		4 / 5 LYS D 135
LEU D 136
LEU C  74
LYS C  78
 None
 1.10A 4k4yI-3aebD:
undetectable		 4k4yI-3aebD:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 ILE C  50
ALA C  54
SER C  57
LEU C  58
LEU C  61
 None
 0.93A 4o1zA-3aebC:
undetectable		 4o1zA-3aebC:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 9 ALA B 162
ALA B 182
LEU B 229
LEU B 160
SER B  72
 None
SF4  B 303 (-3.6A)
SF4  B 303 ( 4.5A)
None
None
 1.11A 4or0B-3aebB:
undetectable		 4or0B-3aebB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		3 / 3 ASP B  26
HIS B  29
LYS B  27
 None
 0.84A 4qzuD-3aebB:
undetectable		 4qzuD-3aebB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa;
Sus
scrofa;
Sus
scrofa) 		4 / 5 GLU D  46
SER D  40
GLN B 207
ASP C 112
 None
 1.47A 5fhrB-3aebD:
undetectable		 5fhrB-3aebD:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		5 / 12 PHE B  61
HIS B  29
ARG B  18
ILE B  51
ASP B  56
 None
 1.48A 6bxnA-3aebB:
undetectable		 6bxnA-3aebB:
20.41