SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aeh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 ASN A1093
ILE A1203
SER A1223
ASN A1207
 None
 1.22A 1h7xA-3aehA:
undetectable		 1h7xA-3aehA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 ASN A1093
ILE A1203
SER A1223
ASN A1207
 None
 1.21A 1h7xB-3aehA:
undetectable		 1h7xB-3aehA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 ASN A1093
ILE A1203
SER A1223
ASN A1207
 None
 1.22A 1h7xC-3aehA:
undetectable		 1h7xC-3aehA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 ASN A1093
ILE A1203
SER A1223
ASN A1207
 None
 1.22A 1h7xD-3aehA:
undetectable		 1h7xD-3aehA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		3 / 3 ASP A1111
ASP A1108
LYS A1147
 None
 1.13A 1lqtB-3aehA:
undetectable		 1lqtB-3aehA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		3 / 3 ASP A1111
ASP A1108
LYS A1147
 None
 1.12A 1lquB-3aehA:
undetectable		 1lquB-3aehA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 LEU A1123
ARG A1105
ILE A1199
GLU A1249
ARG A1282
 None
 1.40A 2htuA-3aehA:
undetectable		 2htuA-3aehA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		3 / 3 ASN A1372
ARG A1121
ASP A1197
 None
 0.99A 2qe6A-3aehA:
undetectable		 2qe6A-3aehA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		3 / 3 ASN A1372
ARG A1121
ASP A1197
 None
 0.95A 2qe6B-3aehA:
undetectable		 2qe6B-3aehA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 THR A1299
GLY A1107
GLY A1352
LEU A1109
GLU A1354
 None
 1.14A 2zw9B-3aehA:
undetectable		 2zw9B-3aehA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 11 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
 None
 0.97A 3a51A-3aehA:
undetectable		 3a51A-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
 None
 0.94A 3a51B-3aehA:
undetectable		 3a51B-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
 None
 0.94A 3a51C-3aehA:
undetectable		 3a51C-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
 None
 0.95A 3a51D-3aehA:
undetectable		 3a51D-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
 None
 0.95A 3a51E-3aehA:
undetectable		 3a51E-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 9 LEU A1139
LEU A1122
TRP A1119
ALA A1161
TYR A1227
 None
 1.49A 3cldA-3aehA:
undetectable		 3cldA-3aehA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 LEU A1139
ASP A1100
ARG A1121
GLU A1098
ALA A1228
 None
 1.46A 3k37B-3aehA:
undetectable		 3k37B-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 ARG A1282
GLY A1281
GLU A1231
GLU A1249
 None
 1.12A 3k9fA-3aehA:
undetectable
3k9fB-3aehA:
undetectable
3k9fD-3aehA:
undetectable		 3k9fA-3aehA:
21.22
3k9fB-3aehA:
21.22
3k9fD-3aehA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		3 / 3 TYR A1137
TYR A1363
GLU A1098
 None
 0.98A 3pfgA-3aehA:
undetectable		 3pfgA-3aehA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 GLY A1253
ALA A1228
TYR A1227
GLU A1249
 None
 0.86A 4ae1A-3aehA:
undetectable		 4ae1A-3aehA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 6 ALA A1343
ASN A1342
LEU A1351
GLU A1354
 None
 1.03A 4g24A-3aehA:
undetectable		 4g24A-3aehA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 7 ASN A1372
GLN A1141
ASN A1101
ASP A1100
 None
 1.43A 4kcnB-3aehA:
undetectable		 4kcnB-3aehA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		5 / 12 PRO A1278
LEU A1255
GLY A1127
ASP A1135
THR A1365
 None
 1.43A 4mubA-3aehA:
undetectable		 4mubA-3aehA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 7 ARG A1282
GLN A1247
GLU A1245
ARG A1301
 None
 1.29A 4mv7A-3aehA:
undetectable		 4mv7A-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 7 GLU A1098
PHE A1095
LYS A1201
TYR A1202
 None
 1.09A 4uciB-3aehA:
undetectable		 4uciB-3aehA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 5 SER A1287
VAL A1286
GLY A1303
ALA A1302
 None
 0.95A 5k50A-3aehA:
undetectable		 5k50A-3aehA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER
(Escherichia
coli) 		4 / 5 THR A1290
ASP A1108
GLU A1245
ASN A1101
 None
 1.42A 5ybbA-3aehA:
undetectable		 5ybbA-3aehA:
20.12