SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 GLY A 187
ALA A 289
THR A 236
THR A  85
 AN7  A1001 (-3.5A)
AN7  A1001 ( 3.9A)
None
AN7  A1001 (-3.7A)
 0.89A 1c9sT-3aexA:
undetectable
1c9sU-3aexA:
undetectable		 1c9sT-3aexA:
11.36
1c9sU-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 GLY A 187
ALA A 289
THR A 236
THR A  85
 AN7  A1001 (-3.5A)
AN7  A1001 ( 3.9A)
None
AN7  A1001 (-3.7A)
 0.91A 1gtfL-3aexA:
undetectable
1gtfM-3aexA:
undetectable		 1gtfL-3aexA:
11.36
1gtfM-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.04A 1gtnB-3aexA:
undetectable
1gtnC-3aexA:
undetectable		 1gtnB-3aexA:
11.36
1gtnC-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.04A 1gtnH-3aexA:
undetectable
1gtnI-3aexA:
undetectable		 1gtnH-3aexA:
11.36
1gtnI-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 11 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.08A 1gtnM-3aexA:
undetectable
1gtnN-3aexA:
undetectable		 1gtnM-3aexA:
11.36
1gtnN-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.04A 1gtnU-3aexA:
undetectable
1gtnV-3aexA:
undetectable		 1gtnU-3aexA:
11.36
1gtnV-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.04A 1gtnL-3aexA:
undetectable
1gtnV-3aexA:
undetectable		 1gtnL-3aexA:
11.36
1gtnV-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 8 SER A 155
ASN A 157
GLN A 164
THR A 193
 PO4  A6265 (-3.0A)
None
None
None
 1.02A 1ig3A-3aexA:
2.2
1ig3B-3aexA:
2.2		 1ig3A-3aexA:
20.50
1ig3B-3aexA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 9 THR A  29
GLY A  27
GLY A 318
GLU A  52
GLY A  58
 None
None
AN7  A1001 ( 4.0A)
None
None
 1.26A 1l5kA-3aexA:
undetectable		 1l5kA-3aexA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 1utdT-3aexA:
undetectable
1utdU-3aexA:
undetectable		 1utdT-3aexA:
11.36
1utdU-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 PRO A 288
PHE A 285
ALA A 325
THR A 326
TYR A 275
 None
 1.46A 2axnA-3aexA:
undetectable		 2axnA-3aexA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 THR A  57
ASP A  62
VAL A 153
LEU A 107
 None
 1.03A 2hdnE-3aexA:
undetectable
2hdnF-3aexA:
2.9
2hdnH-3aexA:
2.5		 2hdnE-3aexA:
7.06
2hdnF-3aexA:
22.22
2hdnH-3aexA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 VAL A 153
LEU A 107
THR A  57
ASP A  62
 None
 0.99A 2hdnF-3aexA:
2.8
2hdnG-3aexA:
undetectable
2hdnH-3aexA:
2.5		 2hdnF-3aexA:
22.22
2hdnG-3aexA:
7.06
2hdnH-3aexA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ARG A  63
GLY A  64
SER A 248
 None
 0.62A 2xctB-3aexA:
undetectable		 2xctB-3aexA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 6 HIS A 159
ALA A  72
ALA A 151
THR A 145
 None
 0.84A 2xfhA-3aexA:
undetectable		 2xfhA-3aexA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 PHE A  60
GLY A  64
ALA A 194
LEU A 161
VAL A  69
 AN7  A1001 (-4.7A)
None
None
None
None
 1.06A 2zulA-3aexA:
undetectable		 2zulA-3aexA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 PHE A  60
GLY A  64
ALA A 194
LEU A 161
VAL A  69
 AN7  A1001 (-4.7A)
None
None
None
None
 1.07A 3dmhA-3aexA:
2.0		 3dmhA-3aexA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 THR A 317
THR A 315
HIS A 182
ILE A 241
TYR A 199
 AN7  A1001 (-2.8A)
None
None
AN7  A1001 (-4.7A)
None
 1.47A 3gwxB-3aexA:
undetectable		 3gwxB-3aexA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 THR A 166
LYS A 322
GLU A 170
 None
 0.93A 3ijdB-3aexA:
undetectable		 3ijdB-3aexA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 ARG A 242
ASP A 135
ASP A 136
ARG A 233
 None
 1.48A 3naiC-3aexA:
undetectable		 3naiC-3aexA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 LEU A 301
GLU A  39
LEU A 306
ILE A  45
 None
 0.83A 3s56B-3aexA:
undetectable		 3s56B-3aexA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 GLU A 264
ALA A 265
PHE A 217
 None
 0.63A 4v1fA-3aexA:
undetectable		 4v1fA-3aexA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 GLU A 264
ALA A 265
PHE A 217
 None
 0.60A 4v1fC-3aexA:
undetectable		 4v1fC-3aexA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.06A 5eeuF-3aexA:
undetectable
5eeuG-3aexA:
undetectable		 5eeuF-3aexA:
11.36
5eeuG-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.06A 5eeuI-3aexA:
undetectable
5eeuJ-3aexA:
undetectable		 5eeuI-3aexA:
11.36
5eeuJ-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5eeuO-3aexA:
undetectable
5eeuP-3aexA:
undetectable		 5eeuO-3aexA:
11.36
5eeuP-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.09A 5eeuQ-3aexA:
undetectable
5eeuR-3aexA:
undetectable		 5eeuQ-3aexA:
11.36
5eeuR-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.06A 5eevF-3aexA:
undetectable
5eevG-3aexA:
undetectable		 5eevF-3aexA:
11.36
5eevG-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5eevI-3aexA:
undetectable
5eevJ-3aexA:
undetectable		 5eevI-3aexA:
11.36
5eevJ-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5eevO-3aexA:
undetectable
5eevP-3aexA:
undetectable		 5eevO-3aexA:
11.36
5eevP-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.10A 5eevQ-3aexA:
undetectable
5eevR-3aexA:
undetectable		 5eevQ-3aexA:
11.36
5eevR-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5eewF-3aexA:
undetectable
5eewG-3aexA:
undetectable		 5eewF-3aexA:
11.36
5eewG-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5eewI-3aexA:
undetectable
5eewJ-3aexA:
undetectable		 5eewI-3aexA:
11.36
5eewJ-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5eewO-3aexA:
undetectable
5eewP-3aexA:
undetectable		 5eewO-3aexA:
11.36
5eewP-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.10A 5eewQ-3aexA:
undetectable
5eewR-3aexA:
undetectable		 5eewQ-3aexA:
11.36
5eewR-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.06A 5eexF-3aexA:
undetectable
5eexG-3aexA:
undetectable		 5eexF-3aexA:
11.36
5eexG-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5eexO-3aexA:
undetectable
5eexP-3aexA:
undetectable		 5eexO-3aexA:
11.36
5eexP-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.06A 5eeyF-3aexA:
undetectable
5eeyG-3aexA:
undetectable		 5eeyF-3aexA:
11.36
5eeyG-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5eeyO-3aexA:
undetectable
5eeyP-3aexA:
undetectable		 5eeyO-3aexA:
11.36
5eeyP-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.06A 5eezF-3aexA:
undetectable
5eezG-3aexA:
undetectable		 5eezF-3aexA:
11.36
5eezG-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5eezO-3aexA:
undetectable
5eezP-3aexA:
undetectable		 5eezO-3aexA:
11.36
5eezP-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5ef0F-3aexA:
undetectable
5ef0G-3aexA:
undetectable		 5ef0F-3aexA:
11.36
5ef0G-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5ef0O-3aexA:
undetectable
5ef0P-3aexA:
undetectable		 5ef0O-3aexA:
11.36
5ef0P-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5ef1F-3aexA:
undetectable
5ef1G-3aexA:
undetectable		 5ef1F-3aexA:
11.36
5ef1G-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5ef1O-3aexA:
undetectable
5ef1P-3aexA:
undetectable		 5ef1O-3aexA:
11.36
5ef1P-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5ef2F-3aexA:
undetectable
5ef2G-3aexA:
undetectable		 5ef2F-3aexA:
11.36
5ef2G-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5ef2O-3aexA:
undetectable
5ef2P-3aexA:
undetectable		 5ef2O-3aexA:
11.36
5ef2P-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.07A 5ef3F-3aexA:
undetectable
5ef3G-3aexA:
undetectable		 5ef3F-3aexA:
11.36
5ef3G-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A 187
ALA A 292
THR A 317
ILE A 241
ALA A 293
 AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
None
 1.07A 5ef3O-3aexA:
undetectable
5ef3P-3aexA:
undetectable		 5ef3O-3aexA:
11.36
5ef3P-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_6LHD302_0
(CARBONIC ANHYDRASE 4)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 9 HIS A 195
HIS A 182
LEU A 316
THR A 315
THR A 317
 None
None
None
None
AN7  A1001 (-2.8A)
 1.50A 5jncD-3aexA:
undetectable		 5jncD-3aexA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 HIS A 195
HIS A 182
LEU A 316
THR A 315
THR A 317
 None
None
None
None
AN7  A1001 (-2.8A)
 1.48A 5ku6B-3aexA:
undetectable		 5ku6B-3aexA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 9 ALA A 292
ALA A 274
ALA A 295
ALA A 238
ASP A 268
 None
 1.09A 5l5zK-3aexA:
undetectable
5l5zL-3aexA:
undetectable		 5l5zK-3aexA:
20.90
5l5zL-3aexA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 9 ALA A 292
ALA A 274
ALA A 295
ALA A 238
ASP A 268
 None
 1.09A 5l5zY-3aexA:
undetectable
5l5zZ-3aexA:
undetectable		 5l5zY-3aexA:
20.90
5l5zZ-3aexA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3aex THREONINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 VAL A 153
LEU A 102
ALA A  81
GLY A  86
LEU A 107
 None
None
None
AN7  A1001 (-4.2A)
None
 1.25A 5m5cE-3aexA:
2.1		 5m5cE-3aexA:
22.49