SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3af5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 THR A 284
THR A 281
THR A 365
HIS A 261
None
None
None
ZN  A 665 (-3.3A)
1.32A 1d4fB-3af5A:
2.8
1d4fB-3af5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 PHE A 547
ILE A 545
PHE A 534
VAL A 585
None
0.86A 1fslA-3af5A:
undetectable
1fslA-3af5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 6 HIS A 261
HIS A 344
HIS A 594
HIS A 618
ASP A 260
ZN  A 665 (-3.3A)
ZN  A 662 (-3.4A)
SO4  A 657 (-3.4A)
ZN  A 665 ( 3.3A)
ZN  A 665 ( 2.9A)
1.32A 1fweC-3af5A:
2.8
1fweC-3af5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 7 LEU A 625
ILE A 637
THR A 639
MET A 601
None
1.03A 1kglA-3af5A:
undetectable
1kglA-3af5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 7 PHE A 104
ALA A  85
ILE A 113
ILE A 132
None
0.92A 1oniD-3af5A:
undetectable
1oniF-3af5A:
undetectable
1oniD-3af5A:
12.15
1oniF-3af5A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 7 GLY A 347
ASP A 286
TYR A 472
THR A 322
None
None
None
ACY  A 660 (-4.0A)
1.16A 2aouB-3af5A:
undetectable
2aouB-3af5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 LEU A 443
ILE A 452
PHE A 497
ILE A 519
None
0.85A 2azxA-3af5A:
undetectable
2azxA-3af5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 LEU A 412
ILE A 546
LEU A 427
SER A 544
None
0.86A 2byoA-3af5A:
undetectable
2byoA-3af5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 7 SER A 203
ASP A 217
VAL A 200
LEU A 600
None
0.97A 2hdnE-3af5A:
undetectable
2hdnF-3af5A:
2.2
2hdnH-3af5A:
undetectable
2hdnE-3af5A:
4.77
2hdnF-3af5A:
18.50
2hdnH-3af5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 7 VAL A 200
LEU A 600
SER A 203
ASP A 217
None
1.02A 2hdnF-3af5A:
2.2
2hdnG-3af5A:
undetectable
2hdnH-3af5A:
undetectable
2hdnF-3af5A:
18.50
2hdnG-3af5A:
4.77
2hdnH-3af5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 THR A 255
SER A 203
ASP A 217
VAL A 200
None
1.12A 2hdnI-3af5A:
undetectable
2hdnJ-3af5A:
undetectable
2hdnL-3af5A:
undetectable
2hdnI-3af5A:
4.77
2hdnJ-3af5A:
18.50
2hdnL-3af5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 VAL A 200
THR A 255
SER A 203
ASP A 217
None
1.12A 2hdnJ-3af5A:
undetectable
2hdnK-3af5A:
undetectable
2hdnL-3af5A:
undetectable
2hdnJ-3af5A:
18.50
2hdnK-3af5A:
4.77
2hdnL-3af5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 ALA A 465
ILE A 468
SER A 150
LYS A 293
None
1.13A 2othA-3af5A:
undetectable
2othA-3af5A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 11 ASP A 260
HIS A 261
HIS A 344
ASP A 367
HIS A 618
ZN  A 665 ( 2.9A)
ZN  A 665 (-3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
ZN  A 665 ( 3.3A)
0.58A 2q0jB-3af5A:
11.8
2q0jB-3af5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ALA A 465
LEU A 346
ILE A 484
LEU A 480
PHE A 492
None
1.22A 2qk8A-3af5A:
2.7
2qk8A-3af5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 VAL A 390
VAL A 216
ASP A 217
SER A 203
None
1.19A 2x45A-3af5A:
undetectable
2x45A-3af5A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 VAL A 390
VAL A 216
ASP A 217
SER A 203
None
1.29A 2x45C-3af5A:
undetectable
2x45C-3af5A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 344
ARG A 435
HIS A 256
ASP A 367
ZN  A 662 (-3.4A)
SO4  A 654 (-3.7A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
1.04A 2xadA-3af5A:
undetectable
2xadA-3af5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 344
ARG A 435
HIS A 256
ASP A 367
ZN  A 662 (-3.4A)
SO4  A 654 (-3.7A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
0.99A 2xadB-3af5A:
undetectable
2xadB-3af5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 344
ARG A 435
HIS A 256
ASP A 367
ZN  A 662 (-3.4A)
SO4  A 654 (-3.7A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
1.02A 2xadC-3af5A:
undetectable
2xadC-3af5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 344
ARG A 435
HIS A 256
ASP A 367
ZN  A 662 (-3.4A)
SO4  A 654 (-3.7A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
1.03A 2xadD-3af5A:
undetectable
2xadD-3af5A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 TYR A 550
ARG A 558
ASP A 260
ASP A 217
None
None
ZN  A 665 ( 2.9A)
None
1.45A 2yqzA-3af5A:
2.3
2yqzA-3af5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 TYR A 550
ARG A 558
ASP A 260
ASP A 217
None
None
ZN  A 665 ( 2.9A)
None
1.44A 2yqzB-3af5A:
2.3
2yqzB-3af5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
3 / 3 GLU A 464
ASP A 286
TYR A 472
None
0.88A 2yvlB-3af5A:
2.5
2yvlB-3af5A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 PRO A 611
VAL A 607
THR A 255
GLY A 366
None
1.00A 3elzB-3af5A:
undetectable
3elzB-3af5A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 ALA A 465
LEU A 346
ILE A 484
LEU A 480
PHE A 492
None
1.14A 3jw5B-3af5A:
undetectable
3jw5B-3af5A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 ILE A 102
PHE A 104
ASP A 105
GLU A 110
None
0.83A 3kp6A-3af5A:
undetectable
3kp6B-3af5A:
undetectable
3kp6A-3af5A:
13.80
3kp6B-3af5A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ILE A 189
ASP A 334
THR A 209
ILE A 191
ILE A 362
None
1.18A 3kpbA-3af5A:
undetectable
3kpbA-3af5A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ILE A 189
ASP A 334
THR A 209
ILE A 191
ILE A 362
None
1.18A 3kpbC-3af5A:
undetectable
3kpbC-3af5A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 ILE A 189
ASP A 334
THR A 209
ILE A 191
ILE A 362
None
1.18A 3kpbD-3af5A:
undetectable
3kpbD-3af5A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 VAL A 531
ILE A 298
MET A 569
ARG A 435
None
None
None
SO4  A 654 (-3.7A)
1.06A 3mssA-3af5A:
undetectable
3mssA-3af5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 VAL A 531
ILE A 298
MET A 569
ARG A 435
None
None
None
SO4  A 654 (-3.7A)
1.07A 3mssC-3af5A:
undetectable
3mssC-3af5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 VAL A 328
VAL A 351
ILE A 331
ARG A 385
None
None
None
SO4  A 656 (-3.9A)
1.09A 3pyyA-3af5A:
undetectable
3pyyA-3af5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 LEU A 215
LEU A 194
GLY A 195
GLY A 193
None
0.68A 3si7C-3af5A:
undetectable
3si7D-3af5A:
undetectable
3si7C-3af5A:
18.24
3si7D-3af5A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 SER A  71
ARG A  73
PRO A  74
VAL A  46
None
1.01A 3sufC-3af5A:
undetectable
3sufC-3af5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 9 LEU A 194
LEU A 215
ILE A 362
ILE A 189
GLN A 208
None
1.49A 3tmzA-3af5A:
undetectable
3tmzA-3af5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 LEU A 339
LEU A 323
ILE A 364
PRO A 277
VAL A 214
None
1.38A 3w1wB-3af5A:
4.1
3w1wB-3af5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ALA A 342
ASN A 341
ASP A 260
ASP A 217
HIS A 618
None
ACY  A 658 (-3.4A)
ZN  A 665 ( 2.9A)
None
ZN  A 665 ( 3.3A)
1.28A 3w37A-3af5A:
undetectable
3w37A-3af5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ALA A 342
ASN A 341
ASP A 260
ASP A 217
HIS A 618
None
ACY  A 658 (-3.4A)
ZN  A 665 ( 2.9A)
None
ZN  A 665 ( 3.3A)
1.29A 3welA-3af5A:
undetectable
3welA-3af5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ALA A 342
ASN A 341
ASP A 260
ASP A 217
HIS A 618
None
ACY  A 658 (-3.4A)
ZN  A 665 ( 2.9A)
None
ZN  A 665 ( 3.3A)
1.30A 3wemA-3af5A:
2.1
3wemA-3af5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ALA A 342
ASN A 341
ASP A 260
ASP A 217
HIS A 618
None
ACY  A 658 (-3.4A)
ZN  A 665 ( 2.9A)
None
ZN  A 665 ( 3.3A)
1.30A 3wenA-3af5A:
2.1
3wenA-3af5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 ALA A 342
ASN A 341
ASP A 260
ASP A 217
HIS A 618
None
ACY  A 658 (-3.4A)
ZN  A 665 ( 2.9A)
None
ZN  A 665 ( 3.3A)
1.31A 3weoA-3af5A:
undetectable
3weoA-3af5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 9 ASP A 589
ILE A 588
GLY A 590
PHE A 591
VAL A 415
None
1.32A 4acaB-3af5A:
2.7
4acaC-3af5A:
2.6
4acaB-3af5A:
22.65
4acaC-3af5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 8 ASP A 589
ILE A 588
GLY A 590
PHE A 591
VAL A 415
None
1.31A 4acbB-3af5A:
2.7
4acbC-3af5A:
2.2
4acbB-3af5A:
22.65
4acbC-3af5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 LEU A 476
TYR A 472
GLY A 347
LEU A 375
GLY A 434
None
None
None
None
SO4  A 654 (-3.4A)
1.08A 4blvA-3af5A:
2.4
4blvA-3af5A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 HIS A 256
HIS A 258
ASP A 260
HIS A 344
HIS A 618
ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.87A 4c1dB-3af5A:
9.1
4c1dB-3af5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 TYR A 550
HIS A 256
HIS A 258
ASP A 260
HIS A 344
None
ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
1.41A 4c1dB-3af5A:
9.1
4c1dB-3af5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 11 HIS A 256
HIS A 258
ASP A 260
HIS A 344
HIS A 618
ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.90A 4c1fA-3af5A:
9.7
4c1fB-3af5A:
2.7
4c1fA-3af5A:
16.46
4c1fB-3af5A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 9 HIS A 256
HIS A 258
ASP A 260
HIS A 344
HIS A 618
ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.90A 4c1hA-3af5A:
8.6
4c1hA-3af5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 258
ASP A 260
HIS A 344
HIS A 618
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.81A 4exsB-3af5A:
9.7
4exsB-3af5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 PHE A 235
PRO A 233
GLY A 193
ASN A 644
LEU A 215
None
None
None
SO4  A 652 (-4.0A)
None
1.10A 4kowA-3af5A:
undetectable
4kowA-3af5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 GLY A 109
GLU A 110
ASP A  75
ASP A 105
None
0.99A 4uckB-3af5A:
undetectable
4uckB-3af5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
3 / 3 TYR A 229
ARG A 202
LYS A 230
SO4  A 652 (-3.8A)
SO4  A 652 (-3.8A)
SO4  A 652 (-3.1A)
1.38A 4wq5B-3af5A:
undetectable
4wq5B-3af5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 258
ASP A 260
HIS A 344
HIS A 618
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.76A 5a5zA-3af5A:
8.5
5a5zA-3af5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 VAL A 200
HIS A 258
HIS A 344
HIS A 618
None
ZN  A 662 ( 3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.81A 5a5zA-3af5A:
8.5
5a5zA-3af5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
6 / 11 HIS A 256
HIS A 258
ASP A 260
HIS A 261
HIS A 344
HIS A 618
ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 665 (-3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.40A 5ayaA-3af5A:
11.4
5ayaA-3af5A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 LEU A 625
ILE A 637
THR A 639
MET A 601
None
1.10A 5ljeA-3af5A:
undetectable
5ljeA-3af5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 PRO A 455
TYR A 457
ILE A 518
ILE A 517
ILE A 420
None
1.47A 5mzrA-3af5A:
undetectable
5mzrA-3af5A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 PRO A 455
TYR A 457
ILE A 518
ILE A 517
ILE A 420
None
1.45A 5mzrC-3af5A:
undetectable
5mzrC-3af5A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 9 PRO A 455
TYR A 457
ILE A 518
ILE A 517
ILE A 420
None
1.47A 5mzrD-3af5A:
undetectable
5mzrD-3af5A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
7 / 10 HIS A 256
HIS A 258
HIS A 261
HIS A 344
ASP A 367
TYR A 395
HIS A 594
ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 (-3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
None
SO4  A 657 (-3.4A)
0.43A 5nzwA-3af5A:
23.0
5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 HIS A 256
HIS A 344
HIS A 261
THR A 616
HIS A 618
ZN  A 662 (-3.4A)
ZN  A 662 (-3.4A)
ZN  A 665 (-3.3A)
None
ZN  A 665 ( 3.3A)
1.12A 5nzwA-3af5A:
23.0
5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 HIS A 261
HIS A 618
HIS A 256
ASP A 367
HIS A 344
ZN  A 665 (-3.3A)
ZN  A 665 ( 3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
ZN  A 662 (-3.4A)
1.06A 5nzwA-3af5A:
23.0
5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 10 HIS A 344
HIS A 256
HIS A 594
ASP A 367
HIS A 618
ZN  A 662 (-3.4A)
ZN  A 662 (-3.4A)
SO4  A 657 (-3.4A)
ZN  A 665 (-2.5A)
ZN  A 665 ( 3.3A)
1.05A 5nzwA-3af5A:
23.0
5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 VAL A 207
HIS A 354
LEU A 650
ASP A 334
None
SO4  A 656 (-3.7A)
None
None
1.37A 5vcvA-3af5A:
undetectable
5vcvA-3af5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
3 / 3 THR A 394
GLU A 392
HIS A 344
None
None
ZN  A 662 (-3.4A)
0.80A 5xioA-3af5A:
undetectable
5xioA-3af5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
3 / 3 THR A 394
GLU A 392
HIS A 344
None
None
ZN  A 662 (-3.4A)
0.81A 5xiqB-3af5A:
undetectable
5xiqB-3af5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
3 / 3 THR A 394
GLU A 392
HIS A 344
None
None
ZN  A 662 (-3.4A)
0.82A 5xiqD-3af5A:
undetectable
5xiqD-3af5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 ALA A 342
SER A 348
GLY A 347
TYR A 325
None
1.08A 5yodB-3af5A:
undetectable
5yodB-3af5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 ALA A 342
SER A 348
GLY A 347
TYR A 325
None
1.15A 5yodD-3af5A:
undetectable
5yodD-3af5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 258
ASP A 260
HIS A 256
HIS A 618
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
1.04A 5zj8A-3af5A:
9.6
5zj8A-3af5A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 8 HIS A 258
ASP A 260
HIS A 344
HIS A 618
ZN  A 662 ( 3.3A)
ZN  A 665 ( 2.9A)
ZN  A 662 (-3.4A)
ZN  A 665 ( 3.3A)
0.85A 5zj8A-3af5A:
9.6
5zj8A-3af5A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 VAL A 426
ILE A 456
ILE A 416
LEU A 458
ALA A 520
None
1.17A 6ajiA-3af5A:
undetectable
6ajiA-3af5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 LEU A 458
ILE A 462
GLY A 460
ILE A 456
ILE A 519
None
0.86A 6emuA-3af5A:
undetectable
6emuA-3af5A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
5 / 12 LEU A 458
ILE A 462
GLY A 460
ILE A 456
ILE A 519
None
0.89A 6emuC-3af5A:
undetectable
6emuC-3af5A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 5 LEU A 205
LEU A 353
THR A 365
PRO A 609
None
1.00A 6ew0F-3af5A:
undetectable
6ew0F-3af5A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii)
4 / 6 LEU A 205
LEU A 353
THR A 365
PRO A 609
None
1.00A 6ew0G-3af5A:
undetectable
6ew0G-3af5A:
8.84