SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3afb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 4 ILE A 613
LEU A 610
VAL A 606
ALA A 599
None
0.74A 1mz9A-3afbA:
undetectable
1mz9A-3afbA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 5 ILE A 613
LEU A 610
VAL A 606
ALA A 599
None
0.73A 1mz9C-3afbA:
undetectable
1mz9C-3afbA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 GLN A 497
ASP A 530
ILE A 529
ILE A 568
None
0.92A 1p7lD-3afbA:
undetectable
1p7lD-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 GLN A 497
ASP A 530
ILE A 529
ILE A 568
None
0.92A 1p7lC-3afbA:
undetectable
1p7lC-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 GLN A 497
ASP A 530
ILE A 529
ILE A 568
None
0.89A 1rg9B-3afbA:
undetectable
1rg9B-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 GLN A 497
ASP A 530
ILE A 529
ILE A 568
None
0.90A 1rg9A-3afbA:
undetectable
1rg9A-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 GLN A 497
ASP A 530
ILE A 529
ILE A 568
None
0.90A 1rg9D-3afbA:
undetectable
1rg9D-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 GLN A 497
ASP A 530
ILE A 529
ILE A 568
None
0.91A 1rg9C-3afbA:
undetectable
1rg9C-3afbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 7 LEU A 476
TYR A 516
MET A 424
ILE A 422
None
1.16A 1tuvA-3afbA:
undetectable
1tuvA-3afbA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 5 PHE A 523
LEU A 505
PHE A 552
MET A 572
None
1.15A 1wrkB-3afbA:
undetectable
1wrkB-3afbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 7 PHE A 523
LEU A 505
PHE A 552
MET A 572
None
1.08A 1wrlA-3afbA:
undetectable
1wrlB-3afbA:
undetectable
1wrlA-3afbA:
13.83
1wrlB-3afbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 5 PHE A 523
LEU A 505
PHE A 552
MET A 572
None
1.09A 1wrlC-3afbA:
undetectable
1wrlC-3afbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 7 PHE A 523
LEU A 505
PHE A 552
MET A 572
None
1.08A 1wrlE-3afbA:
undetectable
1wrlE-3afbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 ILE A 484
ILE A 485
ALA A 486
MET A 424
LEU A 432
None
0.99A 1xzxX-3afbA:
undetectable
1xzxX-3afbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 11 TYR A 421
PHE A 448
GLY A 489
GLU A 526
MET A 585
TRP A 664
None
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A   2 ( 4.4A)
GOL  A   2 (-3.8A)
0.73A 2a3aA-3afbA:
19.2
2a3aA-3afbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 9 PHE A 448
GLY A 489
GLU A 526
ASP A 636
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A 718 ( 3.8A)
GOL  A   2 (-3.8A)
0.73A 2a3aB-3afbA:
19.3
2a3aB-3afbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 9 PHE A 448
GLY A 489
GLU A 526
MET A 585
ASP A 588
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A   2 ( 4.4A)
None
0.84A 2a3aB-3afbA:
19.3
2a3aB-3afbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 9 PHE A 448
GLY A 489
GLU A 526
MET A 585
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A   2 ( 4.4A)
GOL  A   2 (-3.8A)
0.84A 2a3aB-3afbA:
19.3
2a3aB-3afbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 10 PHE A 448
GLY A 489
GLU A 526
ASP A 636
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A 718 ( 3.8A)
GOL  A   2 (-3.8A)
0.97A 2a3bB-3afbA:
19.2
2a3bB-3afbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 GLY A 489
PHE A 523
ALA A 527
ASN A 583
PHE A 550
GOL  A   2 ( 3.7A)
None
None
None
None
1.02A 2dpmA-3afbA:
undetectable
2dpmA-3afbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 6 SER A 678
GLY A 683
THR A 684
ARG A 682
None
1.19A 2f7fA-3afbA:
2.3
2f7fA-3afbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 ALA A 563
GLY A 561
GLY A 559
VAL A 606
PRO A 555
None
1.09A 2okcA-3afbA:
undetectable
2okcA-3afbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 ALA A 563
GLY A 561
GLY A 559
VAL A 606
PRO A 555
None
1.09A 2okcB-3afbA:
undetectable
2okcB-3afbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 9 TYR A 421
PHE A 448
GLY A 489
ALA A 490
GLU A 526
TRP A 664
None
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.5A)
GOL  A   2 (-3.7A)
GOL  A   2 (-3.8A)
0.50A 2uy4A-3afbA:
19.4
2uy4A-3afbA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 11 TYR A 421
PHE A 448
GLY A 489
ALA A 490
GLU A 526
TRP A 664
None
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.5A)
GOL  A   2 (-3.7A)
GOL  A   2 (-3.8A)
0.69A 2xtkA-3afbA:
19.6
2xtkA-3afbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 10 TYR A 421
PHE A 448
GLY A 489
ALA A 490
GLU A 526
TRP A 664
None
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.5A)
GOL  A   2 (-3.7A)
GOL  A   2 (-3.8A)
0.51A 2xtkB-3afbA:
19.7
2xtkB-3afbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 11 TYR A 421
PHE A 448
GLY A 489
GLU A 526
MET A 585
TRP A 664
None
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A   2 ( 4.4A)
GOL  A   2 (-3.8A)
0.78A 3g6mA-3afbA:
19.3
3g6mA-3afbA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 ILE A 484
ILE A 485
ALA A 486
MET A 424
LEU A 432
None
1.04A 3uvvA-3afbA:
undetectable
3uvvA-3afbA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 11 PHE A 448
GLY A 489
GLU A 526
ASP A 636
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A 718 ( 3.8A)
GOL  A   2 (-3.8A)
0.62A 3wqvA-3afbA:
20.4
3wqvA-3afbA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 11 PHE A 448
GLY A 489
GLU A 526
MET A 585
ASP A 588
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A   2 ( 4.4A)
None
GOL  A   2 (-3.8A)
0.76A 3wqvA-3afbA:
20.4
3wqvA-3afbA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 11 PHE A 448
GLY A 489
GLU A 526
ASP A 636
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A 718 ( 3.8A)
GOL  A   2 (-3.8A)
0.64A 3wqwA-3afbA:
20.4
3wqwA-3afbA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
6 / 11 PHE A 448
GLY A 489
GLU A 526
MET A 585
ASP A 588
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A   2 ( 4.4A)
None
GOL  A   2 (-3.8A)
0.75A 3wqwA-3afbA:
20.4
3wqwA-3afbA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
3 / 3 PHE A 695
ILE A 632
ASP A 688
None
0.71A 5cswA-3afbA:
0.4
5cswA-3afbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
3 / 3 PHE A 695
ILE A 632
ASP A 688
None
0.68A 5cswB-3afbA:
0.6
5cswB-3afbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
4 / 8 PHE A 448
GLY A 489
GLU A 526
ASP A 588
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
None
0.72A 5gqbA-3afbA:
19.5
5gqbA-3afbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 8 PHE A 448
GLY A 489
GLU A 526
ASP A 636
TRP A 664
GOL  A   2 (-4.6A)
GOL  A   2 ( 3.7A)
GOL  A   2 (-3.7A)
GOL  A 718 ( 3.8A)
GOL  A   2 (-3.8A)
0.67A 5gqbA-3afbA:
19.5
5gqbA-3afbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 LEU A 432
LEU A 466
TRP A 460
ALA A 518
LEU A 521
None
1.18A 5iepA-3afbA:
undetectable
5iepA-3afbA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 GLY A 488
ALA A 447
ALA A 524
ASP A 522
TYR A 421
None
1.21A 5kvaB-3afbA:
3.7
5kvaB-3afbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 12 GLY A 489
ALA A 447
ALA A 524
ASP A 522
TYR A 421
GOL  A   2 ( 3.7A)
None
None
None
None
1.20A 5kvaB-3afbA:
3.7
5kvaB-3afbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)
3afb PUTATIVE CHITINASE
(Pyrococcus
furiosus)
5 / 11 HIS A 681
SER A 678
HIS A 670
ASP A 686
PRO A 687
None
1.44A 5z0fA-3afbA:
undetectable
5z0fB-3afbA:
undetectable
5z0fA-3afbA:
12.93
5z0fB-3afbA:
14.52