SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3afe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  70
ARG A  73
ARG A  74
LEU A  13
 None
 0.86A 1cmaA-3afeA:
undetectable
1cmaB-3afeA:
undetectable		 1cmaA-3afeA:
13.21
1cmaB-3afeA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 8 THR A  82
GLY A  83
GLY A 191
LEU A  36
GLY A 144
 None
 1.37A 1jhqA-3afeA:
undetectable		 1jhqA-3afeA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  16
LEU A  20
MET A 248
GLY A 247
 None
 0.94A 1os6A-3afeA:
undetectable		 1os6A-3afeA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q72_H_COCH401_1
(FAB M82G2, HEAVY
CHAIN
FAB M82G2, LIGHT
CHAIN)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 10 ASN A 371
VAL A 394
GLN A 326
GLY A 234
HIS A  92
 None
 1.39A 1q72H-3afeA:
0.0
1q72L-3afeA:
0.0		 1q72H-3afeA:
18.43
1q72L-3afeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 107
ASP A 111
PRO A 172
LEU A 170
 None
 1.03A 1z2bB-3afeA:
undetectable		 1z2bB-3afeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 11 THR A 347
ALA A 255
GLU A 258
PRO A 354
PHE A 358
 None
 1.25A 2admA-3afeA:
undetectable		 2admA-3afeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 11 THR A 347
ALA A 255
GLU A 258
PRO A 354
PHE A 358
 None
 1.26A 2admB-3afeA:
undetectable		 2admB-3afeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
ALA A 222
ASP A 215
ALA A 212
ASP A 100
 None
 0.90A 3id6C-3afeA:
undetectable		 3id6C-3afeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  95
PHE A  68
PHE A  69
 None
 0.78A 3lk0D-3afeA:
undetectable		 3lk0D-3afeA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 324
ALA A 320
GLU A 317
HIS A 383
 None
 1.38A 3mbgB-3afeA:
0.0
3mbgC-3afeA:
0.0		 3mbgB-3afeA:
12.72
3mbgC-3afeA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 317
HIS A 383
ARG A 324
ALA A 320
 None
 1.36A 3mbgB-3afeA:
0.1
3mbgC-3afeA:
0.1		 3mbgB-3afeA:
12.72
3mbgC-3afeA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 SER A 143
SER A 142
HIS A 147
 None
 0.70A 3mzeA-3afeA:
undetectable		 3mzeA-3afeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 SER A 192
SER A 142
HIS A 147
 None
 0.71A 3mzeA-3afeA:
undetectable		 3mzeA-3afeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
ALA A 222
ASP A 215
ALA A 212
ASP A 100
 None
 0.85A 3nmuA-3afeA:
undetectable
3nmuF-3afeA:
undetectable		 3nmuA-3afeA:
22.01
3nmuF-3afeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
ALA A 222
ASP A 215
ALA A 212
ASP A 100
 None
 0.94A 3nvkI-3afeA:
undetectable		 3nvkI-3afeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
ALA A 222
ASP A 215
ALA A 212
ASP A 100
 None
 0.81A 3nvkF-3afeA:
2.3
3nvkJ-3afeA:
undetectable		 3nvkF-3afeA:
22.48
3nvkJ-3afeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  88
LEU A 187
THR A 330
THR A  30
 None
 1.25A 3nxuA-3afeA:
1.6		 3nxuA-3afeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
ALA A 222
ASP A 215
ALA A 212
ASP A 100
 None
 0.97A 4df3A-3afeA:
undetectable		 4df3A-3afeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 219
ALA A 222
ASP A 215
ALA A 212
ASP A 100
 None
 0.98A 4df3B-3afeA:
undetectable		 4df3B-3afeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  16
LEU A  20
MET A 248
GLY A 247
 None
 0.99A 4hajA-3afeA:
undetectable		 4hajA-3afeA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 133
HIS A  92
HIS A  95
MET A 213
TYR A 210
 None
 1.31A 4qa0A-3afeA:
undetectable		 4qa0A-3afeA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		5 / 11 TYR A 133
HIS A  92
HIS A  95
MET A 213
TYR A 210
 None
 1.26A 4qa0B-3afeA:
undetectable		 4qa0B-3afeA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 223
ASN A 224
SER A 225
 None
 0.76A 4tvtA-3afeA:
undetectable		 4tvtA-3afeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 MET A 213
HIS A  95
GLY A 167
 None
 0.68A 5gwzB-3afeA:
undetectable		 5gwzB-3afeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  15
ASN A  18
LEU A  19
 None
 0.40A 5i1nC-3afeA:
undetectable		 5i1nC-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  15
ASN A  18
LEU A  19
 None
 0.38A 5i1nB-3afeA:
undetectable		 5i1nB-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  15
ASN A  18
LEU A  19
 None
 0.35A 5i1oC-3afeA:
undetectable		 5i1oC-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  15
ASN A  18
LEU A  19
 None
 0.44A 5i1oA-3afeA:
undetectable		 5i1oA-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  15
ASN A  18
LEU A  19
 None
 0.27A 5i1pA-3afeA:
undetectable		 5i1pA-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  15
ASN A  18
LEU A  19
 None
 0.39A 5i1pD-3afeA:
undetectable		 5i1pD-3afeA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 243
LEU A  75
ALA A  71
PHE A  49
GLY A  90
LEU A  53
 None
 1.18A 5te0A-3afeA:
undetectable		 5te0A-3afeA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3afe HYDROXYLASE,
PUTATIVE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 299
ASN A 300
ASP A 303
ARG A 321
 None
 0.97A 6dwdA-3afeA:
undetectable
6dwdC-3afeA:
undetectable		 6dwdA-3afeA:
21.86
6dwdC-3afeA:
21.86