SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3afl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 555
GLU A 254
PHE A 462
TRP A 467
 MAW  A1003 (-4.9A)
LGU  A1002 (-4.5A)
MAW  A1003 (-4.4A)
MAW  A1003 (-3.8A)
 1.10A 1b2iA-3aflA:
undetectable		 1b2iA-3aflA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 GLN A 569
ILE A 714
HIS A 716
 None
 0.73A 1fm9A-3aflA:
undetectable		 1fm9A-3aflA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 402
LEU A 428
MET A 510
GLY A 408
HIS A 516
 None
 1.12A 1g50B-3aflA:
undetectable		 1g50B-3aflA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 11 LEU A 402
LEU A 428
MET A 510
GLY A 408
HIS A 516
 None
 1.12A 1g50C-3aflA:
undetectable		 1g50C-3aflA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 PHE A 393
LEU A 316
VAL A 313
MET A 370
ALA A 353
 None
 1.27A 1gseA-3aflA:
4.7		 1gseA-3aflA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 GLN A 569
ILE A 714
HIS A 716
 None
 0.73A 1k74A-3aflA:
undetectable		 1k74A-3aflA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 210
ASN A 464
TYR A 430
GLY A 425
 None
 1.32A 1mxgA-3aflA:
undetectable		 1mxgA-3aflA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 388
ALA A 133
ALA A 130
VAL A 342
LEU A 125
 None
 1.36A 1rbpA-3aflA:
undetectable		 1rbpA-3aflA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 TRP A 467
ARG A 199
PHE A 462
 MAW  A1003 (-3.8A)
MAW  A1003 (-3.7A)
MAW  A1003 (-4.4A)
 1.25A 1zeaH-3aflA:
4.5
1zeaL-3aflA:
4.3		 1zeaH-3aflA:
13.69
1zeaL-3aflA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 ARG A 314
ALA A 318
GLU A 254
VAL A 293
 LGU  A1002 (-4.3A)
None
LGU  A1002 (-4.5A)
None
 0.83A 2bxgA-3aflA:
2.3		 2bxgA-3aflA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 6 SER A 350
TYR A 365
SER A 524
GLN A 536
 None
LGU  A1002 (-3.5A)
None
None
 1.18A 2cl5B-3aflA:
undetectable		 2cl5B-3aflA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 HIS A 296
ILE A 298
LEU A 316
 None
 0.77A 2kceA-3aflA:
undetectable		 2kceA-3aflA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 6 THR A 243
ARG A 289
THR A 247
ASN A 191
 None
 1.16A 2okcA-3aflA:
2.1		 2okcA-3aflA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 TYR A 542
GLY A 408
ARG A 410
LEU A 423
 None
 0.88A 2vctA-3aflA:
4.6		 2vctA-3aflA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 650
GLN A 656
THR A 721
ILE A 578
ASN A 623
 None
 1.32A 2vdyA-3aflA:
undetectable		 2vdyA-3aflA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 ALA A 360
SER A 310
SER A 532
ALA A 531
 None
LGU  A1002 ( 2.8A)
None
None
 0.82A 2vh3B-3aflA:
undetectable		 2vh3B-3aflA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.14A 2y69C-3aflA:
2.6
2y69N-3aflA:
undetectable
2y69P-3aflA:
2.1		 2y69C-3aflA:
13.68
2y69N-3aflA:
20.15
2y69P-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 6 SER A 350
TYR A 365
SER A 524
GLN A 536
 None
LGU  A1002 (-3.5A)
None
None
 1.15A 2zvjA-3aflA:
undetectable		 2zvjA-3aflA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.16A 3ablC-3aflA:
2.1
3ablN-3aflA:
undetectable
3ablP-3aflA:
2.6		 3ablC-3aflA:
13.68
3ablN-3aflA:
20.15
3ablP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.21A 3asnC-3aflA:
2.0
3asnN-3aflA:
undetectable
3asnP-3aflA:
2.9		 3asnC-3aflA:
13.68
3asnN-3aflA:
20.15
3asnP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.21A 3asoC-3aflA:
2.7
3asoN-3aflA:
undetectable
3asoP-3aflA:
undetectable		 3asoC-3aflA:
13.68
3asoN-3aflA:
20.15
3asoP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 5 ILE A 550
HIS A 715
ARG A 567
GLY A 421
 None
 1.27A 3b9mA-3aflA:
undetectable		 3b9mA-3aflA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 209
ASP A 469
PHE A 472
PRO A 322
ILE A 217
 None
 1.22A 3clbB-3aflA:
undetectable		 3clbB-3aflA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 ASN A 413
MET A 370
PHE A 400
 None
 0.70A 3g4lD-3aflA:
undetectable		 3g4lD-3aflA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 376
SER A 382
ASP A 387
LEU A 388
ALA A 318
 None
 1.06A 3ou6A-3aflA:
undetectable		 3ou6A-3aflA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 376
SER A 382
ASP A 387
LEU A 388
ALA A 318
 None
 1.07A 3ou6C-3aflA:
undetectable		 3ou6C-3aflA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 5 TYR A 349
SER A 310
ASP A 356
ILE A 501
 None
LGU  A1002 ( 2.8A)
None
None
 1.38A 3uj7B-3aflA:
undetectable		 3uj7B-3aflA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.18A 3x2qC-3aflA:
2.5
3x2qN-3aflA:
1.7
3x2qP-3aflA:
2.6		 3x2qC-3aflA:
13.68
3x2qN-3aflA:
20.15
3x2qP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 555
ASP A 416
HIS A 311
HIS A 563
 MAW  A1003 (-4.9A)
None
LGU  A1002 ( 3.9A)
None
 1.27A 3zodA-3aflA:
undetectable		 3zodA-3aflA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 650
GLN A 656
THR A 721
ILE A 578
ASN A 623
 None
 1.32A 4c49B-3aflA:
undetectable		 4c49B-3aflA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 650
GLN A 656
THR A 721
ILE A 578
ASN A 623
 None
 1.35A 4c49C-3aflA:
undetectable		 4c49C-3aflA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 10 ILE A 374
ALA A 376
LEU A 345
PRO A 351
TYR A 389
 None
 1.24A 4g8zX-3aflA:
undetectable		 4g8zX-3aflA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 PRO A  45
LEU A  14
LEU A  96
TRP A  76
 None
 0.99A 4iomA-3aflA:
undetectable		 4iomA-3aflA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 530
LEU A 529
TYR A 365
ASP A 500
GLY A 502
 LGU  A1001 (-3.3A)
None
LGU  A1002 (-3.5A)
None
None
 1.35A 4j7xA-3aflA:
undetectable		 4j7xA-3aflA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 530
LEU A 529
TYR A 365
ASP A 500
GLY A 502
 LGU  A1001 (-3.3A)
None
LGU  A1002 (-3.5A)
None
None
 1.32A 4j7xF-3aflA:
undetectable		 4j7xF-3aflA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 632
ARG A 610
HIS A 634
 None
 0.74A 4kf9A-3aflA:
undetectable		 4kf9A-3aflA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 316
LEU A 373
THR A 123
ILE A 380
ALA A 377
 None
 0.96A 4o2bD-3aflA:
undetectable		 4o2bD-3aflA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 VAL A 644
ILE A 643
ILE A 758
PHE A 635
ILE A 506
 None
 1.05A 4pd4C-3aflA:
2.3		 4pd4C-3aflA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 658
LEU A 630
GLU A 632
ALA A 720
LEU A 734
 None
 1.20A 4retA-3aflA:
2.9		 4retA-3aflA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 658
LEU A 630
GLU A 632
ALA A 720
LEU A 734
 None
 1.20A 4retC-3aflA:
undetectable		 4retC-3aflA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 362
ILE A 501
ALA A 353
PHE A 393
PHE A 498
 None
 1.11A 4u8vB-3aflA:
2.8		 4u8vB-3aflA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 362
ILE A 501
ALA A 353
PHE A 393
PHE A 498
 None
 1.15A 4u8yB-3aflA:
undetectable		 4u8yB-3aflA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 6 GLU A  30
PHE A 114
TYR A  90
HIS A  89
 None
 1.17A 4uciA-3aflA:
undetectable		 4uciA-3aflA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 5 LEU A 730
ALA A 720
LEU A 655
VAL A 718
 None
 1.17A 5cr1A-3aflA:
3.2		 5cr1A-3aflA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 PRO A 185
GLN A 200
VAL A 259
GLY A 256
 None
 1.00A 5nzyA-3aflA:
undetectable		 5nzyA-3aflA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		6 / 12 LEU A 338
ALA A 334
LEU A 327
ILE A 380
LEU A 142
LEU A 320
 None
 1.29A 5toaA-3aflA:
undetectable		 5toaA-3aflA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 ARG A 213
TRP A 165
VAL A 173
TYR A 210
 None
 1.06A 5vlmA-3aflA:
undetectable		 5vlmA-3aflA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 HIS A 479
TRP A 143
HIS A 162
LEU A 228
 None
 1.13A 5w97A-3aflA:
undetectable
5w97C-3aflA:
undetectable
5w97c-3aflA:
undetectable		 5w97A-3aflA:
20.15
5w97C-3aflA:
13.68
5w97c-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 HIS A 479
TRP A 143
HIS A 162
LEU A 228
 None
 1.18A 5x19A-3aflA:
undetectable
5x19C-3aflA:
2.1
5x19P-3aflA:
undetectable		 5x19A-3aflA:
20.15
5x19C-3aflA:
13.68
5x19P-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.18A 5xdqC-3aflA:
undetectable
5xdqN-3aflA:
undetectable
5xdqP-3aflA:
undetectable		 5xdqC-3aflA:
13.68
5xdqN-3aflA:
20.15
5xdqP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.17A 5xdxC-3aflA:
2.0
5xdxN-3aflA:
undetectable
5xdxP-3aflA:
undetectable		 5xdxC-3aflA:
13.55
5xdxN-3aflA:
20.15
5xdxP-3aflA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 316
LEU A 373
THR A 123
ILE A 380
ALA A 377
 None
 0.92A 5xiwB-3aflA:
undetectable		 5xiwB-3aflA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.19A 5z86C-3aflA:
2.6
5z86N-3aflA:
undetectable
5z86P-3aflA:
2.7		 5z86C-3aflA:
13.68
5z86N-3aflA:
20.15
5z86P-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.16A 5zcoC-3aflA:
2.7
5zcoN-3aflA:
undetectable
5zcoP-3aflA:
2.1		 5zcoC-3aflA:
13.68
5zcoN-3aflA:
20.15
5zcoP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.17A 5zcpC-3aflA:
undetectable
5zcpN-3aflA:
undetectable
5zcpP-3aflA:
undetectable		 5zcpC-3aflA:
13.68
5zcpN-3aflA:
20.15
5zcpP-3aflA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 TYR A 430
ASN A 464
LEU A 470
 None
 0.73A 6b58A-3aflA:
3.7		 6b58A-3aflA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 228
HIS A 479
TRP A 143
HIS A 162
 None
 1.17A 6nknC-3aflA:
2.4
6nknN-3aflA:
undetectable
6nknP-3aflA:
2.4		 6nknC-3aflA:
13.68
6nknN-3aflA:
20.15
6nknP-3aflA:
13.68