SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3afo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 182
ALA A 199
LEU A 143
VAL A  70
TYR A  96
 None
MPD  A2002 (-3.7A)
None
None
None
 1.27A 1claA-3afoA:
undetectable		 1claA-3afoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 8 ILE A  72
PHE A 184
HIS A 187
LEU A  92
VAL A  70
 None
 1.41A 1fslA-3afoA:
undetectable		 1fslA-3afoA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 267
PHE A 178
SER A 276
LEU A 202
 NAI  A1001 (-3.7A)
MPD  A2001 ( 3.8A)
None
MPD  A2001 ( 4.8A)
 1.11A 1qcaA-3afoA:
undetectable		 1qcaA-3afoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 177
THR A 146
ILE A 153
GLY A 149
 NAI  A1001 (-3.5A)
None
None
None
 0.82A 2jkjE-3afoA:
undetectable		 2jkjE-3afoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 182
PHE A 171
PHE A  88
VAL A 383
 None
 1.20A 2lh6A-3afoA:
undetectable		 2lh6A-3afoA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 275
GLY A 274
VAL A 278
LEU A 286
 None
 0.69A 2oa1B-3afoA:
4.7		 2oa1B-3afoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 165
PRO A 166
THR A 141
VAL A 138
 None
 0.62A 2v32C-3afoA:
undetectable
2v32D-3afoA:
2.7		 2v32C-3afoA:
21.07
2v32D-3afoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 128
PRO A 126
PHE A  33
PRO A 118
 None
 1.37A 3bjwC-3afoA:
undetectable		 3bjwC-3afoA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 9 THR A 146
LEU A  61
SER A  47
ILE A 153
GLY A 156
 None
 1.19A 3cv9A-3afoA:
undetectable		 3cv9A-3afoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 9 THR A 146
SER A  46
LEU A  61
ILE A 153
GLY A 156
 None
 0.96A 3cv9A-3afoA:
undetectable		 3cv9A-3afoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 278
LEU A 207
ILE A 285
ALA A 284
THR A 205
 None
 1.02A 3mdvA-3afoA:
undetectable		 3mdvA-3afoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 202
ARG A 204
ILE A 277
ASN A 395
 MPD  A2001 ( 4.8A)
MPD  A2001 (-3.4A)
None
None
 1.34A 4i00A-3afoA:
undetectable		 4i00A-3afoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  99
TYR A  96
VAL A 101
ILE A  72
LEU A 169
 None
 1.40A 4jqaB-3afoA:
1.0		 4jqaB-3afoA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 210
VAL A 345
GLU A 208
VAL A 221
 None
 1.36A 4p6vB-3afoA:
undetectable
4p6vE-3afoA:
undetectable		 4p6vB-3afoA:
21.93
4p6vE-3afoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 5 SER A  52
ARG A 204
GLY A 379
THR A 262
 None
MPD  A2001 (-3.4A)
None
None
 1.21A 5btiC-3afoA:
undetectable
5btiD-3afoA:
2.7		 5btiC-3afoA:
21.02
5btiD-3afoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 103
HIS A 127
VAL A  34
 None
 0.69A 5jmnC-3afoA:
undetectable		 5jmnC-3afoA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 12 THR A 163
LYS A 376
ARG A 377
SER A 378
GLY A 379
 None
 1.37A 5lf3b-3afoA:
undetectable		 5lf3b-3afoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  67
VAL A  70
LEU A  92
VAL A 145
 None
 0.90A 5x7zA-3afoA:
undetectable		 5x7zA-3afoA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 132
THR A 131
GLN A 104
TYR A  71
 None
 1.28A 6ag0A-3afoA:
undetectable		 6ag0A-3afoA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 132
THR A 131
GLN A 104
TYR A  71
 None
 1.28A 6ag0C-3afoA:
undetectable		 6ag0C-3afoA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  48
ASP A  49
ILE A  62
ILE A 195
VAL A 383
 None
 0.95A 6dj1B-3afoA:
undetectable		 6dj1B-3afoA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  48
ASP A  49
ILE A  62
ILE A 195
VAL A 383
 None
 0.95A 6dj2B-3afoA:
undetectable		 6dj2B-3afoA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.19A 6r2eA-3afoA:
undetectable		 6r2eA-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.17A 6r2eB-3afoA:
undetectable		 6r2eB-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.14A 6r2eC-3afoA:
undetectable		 6r2eC-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.21A 6r2eD-3afoA:
undetectable		 6r2eD-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.19A 6r2eE-3afoA:
undetectable		 6r2eE-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.21A 6r2eF-3afoA:
undetectable		 6r2eF-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.18A 6r2eG-3afoA:
undetectable		 6r2eG-3afoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3afo NADH KINASE POS5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 178
LEU A 144
LEU A 154
GLY A 151
MET A 225
 MPD  A2001 ( 3.8A)
None
NAI  A1001 (-4.9A)
NAI  A1001 (-3.3A)
None
 1.23A 6r2eH-3afoA:
undetectable		 6r2eH-3afoA:
19.80