SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3agk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		4 / 7 LEU A 213
LEU A 158
GLY A 144
LEU A 166
 None
 0.89A 1gtiA-3agkA:
undetectable		 1gtiA-3agkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		3 / 3 PHE A 120
LEU A  37
MET A  79
 None
 0.82A 1mx1D-3agkA:
undetectable		 1mx1D-3agkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		4 / 5 LEU A 320
PRO A 346
VAL A 345
ILE A 343
 None
 0.78A 2aoiB-3agkA:
undetectable		 2aoiB-3agkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		3 / 3 VAL A 137
GLU A 134
GLU A 138
 None
 0.73A 2nv4A-3agkA:
undetectable		 2nv4A-3agkA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		5 / 11 GLN A 258
PRO A 227
LEU A 252
VAL A 235
PHE A 199
 None
 1.43A 3n23C-3agkA:
undetectable		 3n23C-3agkA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		4 / 6 GLY A 364
VAL A 307
GLY A 314
GLU A 312
 None
 0.86A 4dxuA-3agkA:
undetectable		 4dxuA-3agkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		3 / 3 LYS A 295
LEU A 291
ALA A 294
 None
 0.70A 4ikiA-3agkA:
undetectable		 4ikiA-3agkA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Aeropyrum
pernix) 		5 / 10 LEU A 263
VAL A 222
LEU A 248
LEU A 240
VAL A 235
 None
 1.14A 4po0A-3agkA:
2.1		 4po0A-3agkA:
21.94