SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ah5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 7 HIS A 231
HIS A 234
LEU A 196
THR A 195
 None
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 1.09A 1am6A-3ah5A:
undetectable		 1am6A-3ah5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		5 / 11 ALA A 169
LEU A 112
LEU A 155
LEU A 152
SER A 176
 None
 1.01A 1h9zA-3ah5A:
2.6		 1h9zA-3ah5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 8 GLN A  93
LEU A 181
TYR A 183
LEU A 209
 None
 1.10A 1hk3A-3ah5A:
2.7		 1hk3A-3ah5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 6 TYR A  31
LEU A  78
LYS A  59
ASP A  58
 None
 1.43A 2w98A-3ah5A:
undetectable
2w98B-3ah5A:
undetectable		 2w98A-3ah5A:
19.11
2w98B-3ah5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 8 HIS A 231
HIS A 234
LEU A 196
THR A 195
 None
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 1.05A 3w6hA-3ah5A:
undetectable		 3w6hA-3ah5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 6 HIS A 237
HIS A 234
LEU A 196
THR A 195
 SO4  A  10 (-4.1A)
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 0.97A 5ogjA-3ah5A:
undetectable		 5ogjA-3ah5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 6 HIS A 237
HIS A 234
LEU A 196
THR A 195
 SO4  A  10 (-4.1A)
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 0.97A 5ogjB-3ah5A:
undetectable		 5ogjB-3ah5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 5 HIS A 237
HIS A 234
LEU A 196
THR A 195
 SO4  A  10 (-4.1A)
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 0.96A 5ohhA-3ah5A:
undetectable		 5ohhA-3ah5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 6 HIS A 237
HIS A 234
LEU A 196
THR A 195
 SO4  A  10 (-4.1A)
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 0.97A 5ohhB-3ah5A:
undetectable		 5ohhB-3ah5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		5 / 10 LEU A 115
LEU A 150
LEU A 129
ALA A 132
LEU A 136
 None
 1.26A 5y7pD-3ah5A:
undetectable		 5y7pD-3ah5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 3ah5 THYMIDYLATE SYNTHASE
THYX
(Helicobacter
pylori) 		4 / 5 TYR A 183
ASN A 186
TYR A  80
PHE A  82
 None
 1.23A 6h3dA-3ah5A:
undetectable		 6h3dA-3ah5A:
21.09