SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ahm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 GLU A 391
HIS A 356
ASP A 416
 None
ZN  A 565 (-3.4A)
None
 0.78A 1i9gA-3ahmA:
undetectable		 1i9gA-3ahmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.29A 1j36A-3ahmA:
24.7		 1j36A-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.44A 1j36A-3ahmA:
24.7		 1j36A-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.28A 1j36B-3ahmA:
24.7		 1j36B-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.44A 1j36B-3ahmA:
24.7		 1j36B-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 11 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.24A 1j37A-3ahmA:
24.7		 1j37A-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 ( 4.6A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.51A 1j37A-3ahmA:
24.7		 1j37A-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 11 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.24A 1j37B-3ahmA:
24.7		 1j37B-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 ( 4.6A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.50A 1j37B-3ahmA:
24.7		 1j37B-3ahmA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 486
 ACT  A 567 (-3.5A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
None
 1.47A 1o86A-3ahmA:
26.6		 1o86A-3ahmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.28A 1o86A-3ahmA:
26.6		 1o86A-3ahmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		8 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 ( 4.6A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.44A 1o86A-3ahmA:
26.6		 1o86A-3ahmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 6 ASP A 350
ASP A 283
ASN A 285
GLU A 357
 None
None
None
ZN  A 565 ( 4.6A)
 1.11A 1rjdA-3ahmA:
undetectable		 1rjdA-3ahmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 6 ASP A 350
ASP A 283
ASN A 285
GLU A 357
 None
None
None
ZN  A 565 ( 4.6A)
 1.11A 1rjdB-3ahmA:
undetectable		 1rjdB-3ahmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 6 ASP A 350
ASP A 283
ASN A 285
GLU A 357
 None
None
None
ZN  A 565 ( 4.6A)
 1.13A 1rjdC-3ahmA:
undetectable		 1rjdC-3ahmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 LEU A 518
HIS A 386
SER A 387
MET A 388
GLN A 111
 None
None
ZN  A 565 (-3.5A)
None
None
 1.34A 1s2aA-3ahmA:
undetectable		 1s2aA-3ahmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 11 VAL A 261
GLU A 253
ARG A 171
GLU A 262
ASP A 268
 None
 1.42A 1t6zA-3ahmA:
undetectable		 1t6zA-3ahmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 11 VAL A 261
GLU A 253
ARG A 171
GLU A 262
ASP A 268
 None
 1.36A 1t6zB-3ahmA:
undetectable		 1t6zB-3ahmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.92A 1v7zA-3ahmA:
undetectable		 1v7zA-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.93A 1v7zB-3ahmA:
undetectable		 1v7zB-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.93A 1v7zC-3ahmA:
undetectable		 1v7zC-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.95A 1v7zD-3ahmA:
undetectable		 1v7zD-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.95A 1v7zE-3ahmA:
undetectable		 1v7zE-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.94A 1v7zF-3ahmA:
undetectable		 1v7zF-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 PHE A 430
ASP A 428
PHE A 485
VAL A 434
 None
 1.15A 1w0fA-3ahmA:
undetectable		 1w0fA-3ahmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 PHE A   3
TYR A  70
TYR A   8
 None
 1.06A 1x70B-3ahmA:
undetectable		 1x70B-3ahmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 PHE A 498
ALA A 417
LEU A 251
ILE A 247
ILE A 244
 None
 1.22A 1xdkB-3ahmA:
undetectable		 1xdkB-3ahmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 LEU A 162
PHE A 152
ARG A 171
 None
 0.83A 1xdkB-3ahmA:
undetectable		 1xdkB-3ahmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 ASN A 343
GLY A 326
ALA A 324
THR A  62
TYR A  58
 None
 1.08A 2axnA-3ahmA:
undetectable		 2axnA-3ahmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.24A 2c6nA-3ahmA:
25.1		 2c6nA-3ahmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.36A 2c6nA-3ahmA:
25.1		 2c6nA-3ahmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.27A 2c6nB-3ahmA:
24.8		 2c6nB-3ahmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.41A 2c6nB-3ahmA:
24.8		 2c6nB-3ahmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 GLU A  81
ASN A 135
LEU A 199
GLU A 134
ARG A 203
 None
 1.48A 2f10A-3ahmA:
undetectable		 2f10A-3ahmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 11 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.23A 2x8zA-3ahmA:
25.2		 2x8zA-3ahmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 ( 4.6A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.39A 2x8zA-3ahmA:
25.2		 2x8zA-3ahmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 12 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.26A 2x91A-3ahmA:
25.4		 2x91A-3ahmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		7 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.33A 2x91A-3ahmA:
25.4		 2x91A-3ahmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.92A 3a6jA-3ahmA:
undetectable		 3a6jA-3ahmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 7 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.89A 3a6jB-3ahmA:
undetectable		 3a6jB-3ahmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.90A 3a6jC-3ahmA:
undetectable		 3a6jC-3ahmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.94A 3a6jE-3ahmA:
undetectable		 3a6jE-3ahmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 8 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.89A 3a6jF-3ahmA:
undetectable		 3a6jF-3ahmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 11 PHE A 362
MET A 390
SER A 504
PRO A 396
TRP A 397
 None
 1.49A 3aqiA-3ahmA:
0.0		 3aqiA-3ahmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 ILE A 495
ALA A 248
ILE A 247
VAL A 240
PHE A 236
 None
 1.06A 3b2rA-3ahmA:
3.6		 3b2rA-3ahmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 5 TYR A 467
ARG A 476
TYR A 481
THR A 482
 None
 1.01A 3dgqA-3ahmA:
2.0		 3dgqA-3ahmA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 GLU A 179
ASP A 463
ASP A 172
 None
 0.68A 3jb2A-3ahmA:
undetectable		 3jb2A-3ahmA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 HIS A 356
GLU A 357
HIS A 360
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
 0.22A 3kecB-3ahmA:
2.0		 3kecB-3ahmA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 LEU A 131
THR A 204
ILE A 206
ALA A 207
ALA A 221
 None
 0.97A 3mdvB-3ahmA:
undetectable		 3mdvB-3ahmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 7 GLU A  73
GLU A  81
PHE A  50
PRO A  11
 None
 1.40A 3ql6A-3ahmA:
undetectable		 3ql6A-3ahmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 7 LEU A 264
GLU A 269
PRO A 274
ILE A 259
 None
 0.95A 3s56B-3ahmA:
undetectable		 3s56B-3ahmA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 7 LEU A 380
GLY A 219
ALA A 484
PHE A 215
 None
 0.97A 3tehB-3ahmA:
undetectable		 3tehB-3ahmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 9 ILE A 385
ALA A 497
VAL A 548
PHE A 498
PHE A 500
 None
 1.22A 3ti1A-3ahmA:
undetectable		 3ti1A-3ahmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 7 GLU A 391
PHE A 392
TYR A 409
VAL A 559
 None
 1.10A 4a97A-3ahmA:
2.4		 4a97A-3ahmA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 7 ILE A 372
GLU A 374
PHE A 113
TYR A  91
 None
 0.97A 4a97D-3ahmA:
2.3		 4a97D-3ahmA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 11 GLN A 477
GLU A 357
HIS A 360
GLU A 384
TYR A 486
 ACT  A 567 (-3.5A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
None
 1.49A 4c2pA-3ahmA:
25.9		 4c2pA-3ahmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		6 / 11 GLN A 477
HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ACT  A 567 (-3.5A)
ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 1.28A 4c2pA-3ahmA:
25.9		 4c2pA-3ahmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		8 / 11 HIS A 356
GLU A 357
HIS A 360
GLU A 384
PHE A 420
HIS A 479
TYR A 487
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 ( 4.6A)
ACT  A 567 (-4.6A)
ACT  A 567 (-4.5A)
ACT  A 567 (-3.6A)
 0.50A 4c2pA-3ahmA:
25.9		 4c2pA-3ahmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 6 ILE A 452
ARG A 237
GLY A 424
HIS A 432
 None
 1.02A 4oltA-3ahmA:
undetectable		 4oltA-3ahmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 HIS A 356
GLU A 357
HIS A 360
GLU A 384
TYR A 490
 ZN  A 565 (-3.4A)
ZN  A 565 ( 4.6A)
ZN  A 565 (-3.3A)
ZN  A 565 (-2.1A)
ACT  A 567 (-3.6A)
 0.57A 4r7lA-3ahmA:
6.9		 4r7lA-3ahmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 ASP A 428
THR A 379
ALA A 382
ALA A 493
TYR A 228
 None
 1.36A 4u15B-3ahmA:
undetectable		 4u15B-3ahmA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 VAL A 427
PHE A 485
ARG A 203
 None
 0.86A 4xr4B-3ahmA:
undetectable		 4xr4B-3ahmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 5 GLY A 349
GLU A 391
HIS A 356
ASP A 416
 None
None
ZN  A 565 (-3.4A)
None
 0.89A 5c0oH-3ahmA:
undetectable		 5c0oH-3ahmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 PHE A 500
ILE A 385
SER A 524
VAL A 533
PRO A 378
 None
 1.38A 5mlmA-3ahmA:
undetectable		 5mlmA-3ahmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		3 / 3 ALA A 324
GLN A  74
THR A  65
 None
 0.74A 5n0oA-3ahmA:
undetectable		 5n0oA-3ahmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.07A 5n0rA-3ahmA:
undetectable		 5n0rA-3ahmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.09A 5n0sA-3ahmA:
undetectable		 5n0sA-3ahmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 5 SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.06A 5n0tA-3ahmA:
undetectable		 5n0tA-3ahmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 5 TYR A 328
SER A 325
ALA A 324
THR A  65
 None
 0.93A 5n0tA-3ahmA:
undetectable		 5n0tA-3ahmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 TYR A 328
SER A 325
GLN A  74
THR A  65
 None
 1.38A 5n0tB-3ahmA:
0.0		 5n0tB-3ahmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.08A 5n0wA-3ahmA:
undetectable		 5n0wA-3ahmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 5 TYR A 328
SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.11A 5n0wB-3ahmA:
undetectable		 5n0wB-3ahmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.11A 5n0xA-3ahmA:
undetectable		 5n0xA-3ahmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 5 TYR A 328
SER A 325
ALA A 324
GLN A  74
THR A  65
 None
 1.16A 5n4iA-3ahmA:
undetectable		 5n4iA-3ahmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 4 HIS A 356
HIS A 360
TYR A 486
GLU A 384
 ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
None
ZN  A 565 (-2.1A)
 1.22A 5pahA-3ahmA:
undetectable		 5pahA-3ahmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 PHE A 498
ALA A 417
LEU A 251
ILE A 247
ILE A 244
 None
 1.25A 5uanB-3ahmA:
undetectable		 5uanB-3ahmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 12 ILE A 351
LEU A 400
PHE A 402
MET A 294
ASP A 283
 None
 1.09A 5x66A-3ahmA:
undetectable
5x66B-3ahmA:
undetectable		 5x66A-3ahmA:
19.72
5x66B-3ahmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 11 GLU A 231
ALA A 221
THR A 379
LEU A 380
ALA A 382
 None
 1.24A 6efnA-3ahmA:
undetectable		 6efnA-3ahmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		5 / 11 ASP A  78
PHE A  77
ARG A  10
PRO A  11
ILE A  13
 None
 1.49A 6fgdA-3ahmA:
undetectable		 6fgdA-3ahmA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3ahm OLIGOPEPTIDASE
(Geobacillus
sp.
MO-1) 		4 / 6 THR A 379
LEU A 380
THR A 226
LEU A 492
 None
 1.14A 6mvxA-3ahmA:
undetectable
6mvxB-3ahmA:
1.6
6mvxC-3ahmA:
3.6		 6mvxA-3ahmA:
19.33
6mvxB-3ahmA:
19.33
6mvxC-3ahmA:
19.33