SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ahr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		4 / 4 HIS A 261
LEU A  69
LEU A  65
LEU A 312
 None
 1.25A 1a4lD-3ahrA:
undetectable		 1a4lD-3ahrA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		4 / 7 GLU A 311
ARG A 449
THR A 452
VAL A 454
 None
 1.08A 1fo4B-3ahrA:
undetectable		 1fo4B-3ahrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 PHE A  74
LEU A 329
TYR A  73
LEU A 345
LEU A 348
 None
 1.37A 1p33A-3ahrA:
undetectable		 1p33A-3ahrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 LEU A  65
LEU A  68
LEU A 344
ILE A 347
ILE A 351
 None
 1.01A 2bdmA-3ahrA:
undetectable		 2bdmA-3ahrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 11 ILE A 414
LEU A 415
ASP A 359
GLY A  41
PHE A 416
 None
 1.02A 2fxdA-3ahrA:
undetectable		 2fxdA-3ahrA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		4 / 7 TRP A 200
SER A 386
GLN A 404
ILE A 203
 FAD  A   1 (-3.2A)
None
None
None
 1.09A 2xz5A-3ahrA:
undetectable
2xz5B-3ahrA:
undetectable		 2xz5A-3ahrA:
18.16
2xz5B-3ahrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 LEU A 415
ALA A 446
ALA A 314
VAL A 318
LEU A 329
 None
 1.28A 3b0wB-3ahrA:
undetectable		 3b0wB-3ahrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 344
ASN A 340
LEU A 443
LEU A  65
 None
 1.17A 3d90B-3ahrA:
undetectable		 3d90B-3ahrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		4 / 7 ARG A  64
VAL A 441
LEU A 408
ILE A 440
 None
 0.92A 3gp0A-3ahrA:
undetectable		 3gp0A-3ahrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		4 / 7 PHE A 382
PHE A 378
THR A 410
PHE A 416
 None
 0.99A 3vnsA-3ahrA:
undetectable		 3vnsA-3ahrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 ALA A 411
ARG A 449
PHE A 447
ILE A 347
LEU A  61
 None
 1.04A 4kfjB-3ahrA:
undetectable		 4kfjB-3ahrA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 11 LEU A 254
GLU A 186
GLN A 404
LEU A 307
SER A 453
 None
 1.21A 4wnuA-3ahrA:
1.2		 4wnuA-3ahrA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		5 / 10 PHE A 382
ALA A 246
LEU A 250
ILE A 351
LEU A 348
 None
 1.17A 5oy01-3ahrA:
undetectable
5oy07-3ahrA:
undetectable		 5oy01-3ahrA:
11.29
5oy07-3ahrA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens) 		4 / 5 VAL A 152
THR A 156
LEU A 144
LEU A 181
 None
 0.98A 6bqgA-3ahrA:
2.4		 6bqgA-3ahrA:
9.07