SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ahy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 12 ASN A 195
TRP A 190
GLY A 175
SER A 176
THR A 178
 None
 1.41A 1g60A-3ahyA:
undetectable		 1g60A-3ahyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 8 TYR A 429
GLU A  18
GLY A  19
THR A  49
ALA A  50
 None
 1.49A 2ej3A-3ahyA:
undetectable		 2ej3A-3ahyA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 4 ASP A  22
ASP A  32
ASP A  24
GLY A  19
 None
 1.10A 2igtC-3ahyA:
undetectable		 2igtC-3ahyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 7 GLY A 173
PRO A 172
THR A 315
GLY A 175
 None
 0.84A 2jkjE-3ahyA:
undetectable		 2jkjE-3ahyA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 7 PHE A 139
PHE A 118
ILE A  30
GLY A  86
 None
 0.88A 2v0mC-3ahyA:
undetectable		 2v0mC-3ahyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 11 ASN A 164
GLU A 165
TYR A 298
GLU A 367
TRP A 417
 TRS  A 500 ( 4.8A)
TRS  A 500 (-2.9A)
TRS  A 500 (-4.1A)
TRS  A 500 (-3.2A)
TRS  A 500 ( 4.1A)
 0.84A 2v3dB-3ahyA:
15.4		 2v3dB-3ahyA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A  86
ILE A  82
ASP A 121
LEU A 122
GLU A 138
 None
 0.91A 3o7wA-3ahyA:
undetectable		 3o7wA-3ahyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 10 ILE A  30
GLY A 173
TYR A 174
GLU A 188
GLY A 177
 None
 1.17A 4bwlC-3ahyA:
10.3		 4bwlC-3ahyA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 7 GLY A 201
VAL A 286
PHE A 163
ILE A 196
PHE A 118
 None
 1.50A 4fglC-3ahyA:
undetectable		 4fglC-3ahyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 7 VAL A 401
MET A 400
ALA A 399
PHE A 347
 None
 1.03A 4lb2A-3ahyA:
undetectable		 4lb2A-3ahyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B602_1
(SERUM ALBUMIN)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 9 VAL A 401
MET A 400
ALA A 399
PHE A 347
TYR A 298
 None
None
None
None
TRS  A 500 (-4.1A)
 1.39A 4lb2B-3ahyA:
undetectable		 4lb2B-3ahyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 ASP A 121
TRP A 417
SER A  75
 None
TRS  A 500 ( 4.1A)
None
 0.99A 4lrhB-3ahyA:
undetectable		 4lrhB-3ahyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 ASP A 121
TRP A 417
SER A  75
 None
TRS  A 500 ( 4.1A)
None
 1.07A 4lrhF-3ahyA:
undetectable		 4lrhF-3ahyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		5 / 12 TYR A 146
ILE A 222
ALA A 147
HIS A 119
ILE A 196
 None
 1.12A 4rvdA-3ahyA:
undetectable		 4rvdA-3ahyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 ASN A 164
PHE A 415
TYR A  72
 TRS  A 500 ( 4.8A)
None
None
 0.64A 4u15A-3ahyA:
undetectable		 4u15A-3ahyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 4 ALA A 284
PRO A 257
LEU A 275
HIS A 194
 None
 1.21A 5eskA-3ahyA:
undetectable		 5eskA-3ahyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 8 ASP A  60
VAL A 435
GLY A 434
ARG A 389
 None
 1.04A 5nzyA-3ahyA:
1.2		 5nzyA-3ahyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 6 ARG A 183
ALA A 180
PRO A 181
GLU A 124
 None
 1.40A 5odqA-3ahyA:
1.7		 5odqA-3ahyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 8 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
TRS  A 500 (-4.1A)
None
None
 1.27A 5tzoA-3ahyA:
undetectable		 5tzoA-3ahyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 8 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
TRS  A 500 (-4.1A)
None
None
 1.26A 5tzoB-3ahyA:
undetectable		 5tzoB-3ahyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 8 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
TRS  A 500 (-4.1A)
None
None
 1.29A 5tzoC-3ahyA:
undetectable		 5tzoC-3ahyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		4 / 7 VAL A 286
ARG A 136
GLU A 282
LEU A 275
 None
 0.94A 5umwB-3ahyA:
undetectable
5umwE-3ahyA:
undetectable		 5umwB-3ahyA:
11.44
5umwE-3ahyA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 TYR A 263
LEU A 271
ASP A 314
 None
 0.83A 5zv2B-3ahyA:
undetectable		 5zv2B-3ahyA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 ARG A 306
ARG A 304
ASP A 320
 None
 0.95A 6d8pA-3ahyA:
1.5		 6d8pA-3ahyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 MET A 267
GLN A 270
ARG A 245
 None
 1.12A 6fn9A-3ahyA:
undetectable		 6fn9A-3ahyA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3ahy BETA-GLUCOSIDASE
(Trichoderma
reesei) 		3 / 3 MET A 267
GLN A 270
ARG A 245
 None
 1.13A 6fnbA-3ahyA:
undetectable		 6fnbA-3ahyA:
17.55