SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ai5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 12 ALA A 110
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
 1.21A 1ddrB-3ai5A:
undetectable		 1ddrB-3ai5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 12 ALA A 110
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
 1.20A 1jolA-3ai5A:
undetectable		 1jolA-3ai5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 8 LYS A 259
VAL A 258
ASP A 264
LEU A 288
 None
 0.85A 1z2bB-3ai5A:
undetectable		 1z2bB-3ai5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 8 ILE A 235
LEU A 275
ILE A 276
HIS A 300
 None
 0.91A 2azxA-3ai5A:
undetectable		 2azxA-3ai5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 4 GLN A 263
GLU A 266
ILE A 268
PRO A 269
 None
 0.91A 2fcnA-3ai5A:
16.0		 2fcnA-3ai5A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 GLN A 263
GLU A 266
ILE A 268
PRO A 269
 None
 0.44A 2fcnA-3ai5A:
16.0
2fcnB-3ai5A:
16.3		 2fcnA-3ai5A:
27.55
2fcnB-3ai5A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 5 ASP A 180
ARG A 168
ILE A 167
VAL A 150
 None
 1.12A 3eigA-3ai5A:
undetectable		 3eigA-3ai5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 ILE A 188
PHE A  83
ALA A  87
ASN A 185
 None
 1.15A 3pgyA-3ai5A:
undetectable
3pgyB-3ai5A:
undetectable		 3pgyA-3ai5A:
21.69
3pgyB-3ai5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.19A 3t3rB-3ai5A:
undetectable		 3t3rB-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.22A 3t3rC-3ai5A:
undetectable		 3t3rC-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.17A 3t3rD-3ai5A:
undetectable		 3t3rD-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 7 ASP A  19
THR A 108
SER A  28
PHE A  27
 None
 1.03A 4ac9C-3ai5A:
undetectable		 4ac9C-3ai5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 8 VAL A  55
LEU A  53
ILE A  47
VAL A  16
 None
 0.97A 4ma7A-3ai5A:
undetectable		 4ma7A-3ai5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.3A)
 0.94A 4o1zA-3ai5A:
undetectable		 4o1zA-3ai5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 12 ALA A 110
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
 1.15A 4qlgA-3ai5A:
undetectable		 4qlgA-3ai5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 7 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.86A 4w5oA-3ai5A:
undetectable		 4w5oA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.80A 4w5qA-3ai5A:
undetectable		 4w5qA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.81A 4w5tA-3ai5A:
undetectable		 4w5tA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.84A 4z4cA-3ai5A:
undetectable		 4z4cA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.85A 4z4dA-3ai5A:
undetectable		 4z4dA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 7 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.80A 4z4eA-3ai5A:
undetectable		 4z4eA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 7 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.84A 4z4gA-3ai5A:
undetectable		 4z4gA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 12 ALA A 110
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
 1.16A 5e8qB-3ai5A:
undetectable		 5e8qB-3ai5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 12 LEU A 137
GLY A 138
GLN A 177
ILE A 171
ASP A 173
 None
 1.15A 6bxnB-3ai5A:
undetectable		 6bxnB-3ai5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.81A 6cbdA-3ai5A:
undetectable		 6cbdA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 8 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
None
EDO  A 317 (-3.8A)
None
 0.86A 6cduD-3ai5A:
undetectable
6cduE-3ai5A:
undetectable		 6cduD-3ai5A:
20.80
6cduE-3ai5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 8 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
None
EDO  A 317 (-3.8A)
None
 0.91A 6cduG-3ai5A:
undetectable
6cduH-3ai5A:
undetectable		 6cduG-3ai5A:
20.80
6cduH-3ai5A:
20.80