SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ai9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 ALA X 174
PHE X 168
ASN X 121
LEU X 122
VAL X 152
None
1.27A 1u72A-3ai9X:
undetectable
1u72A-3ai9X:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
8 / 9 LEU X 136
ILE X 155
GLY X 156
GLY X 160
SER X 178
SER X 180
LEU X 184
CYH X 189
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
SAM  X 501 (-3.3A)
0.44A 2qmmA-3ai9X:
31.2
2qmmA-3ai9X:
43.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
9 / 11 LEU X 136
ILE X 155
GLY X 156
GLY X 160
SER X 178
LEU X 179
SER X 180
LEU X 184
CYH X 189
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
SAM  X 501 (-3.3A)
0.38A 2qmmA-3ai9X:
31.2
2qmmB-3ai9X:
31.2
2qmmA-3ai9X:
43.81
2qmmB-3ai9X:
43.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 10 LEU X 136
GLY X 156
LEU X 179
SER X 180
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
0.46A 2v3kA-3ai9X:
14.0
2v3kA-3ai9X:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
9 / 9 LEU X 136
ILE X 155
GLY X 156
SER X 178
LEU X 179
SER X 180
GLU X 183
LEU X 184
CYH X 189
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.7A)
SAM  X 501 (-4.3A)
SAM  X 501 (-3.3A)
0.03A 3ai9X-3ai9X:
41.6
3ai9X-3ai9X:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
6 / 6 LEU X 136
MET X 138
GLY X 156
LEU X 179
SER X 180
CYH X 189
SAM  X 501 (-4.3A)
SAM  X 501 (-4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-3.3A)
0.36A 3aiaA-3ai9X:
37.9
3aiaA-3ai9X:
98.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
4 / 5 LEU X 136
GLY X 156
GLU X 183
CYH X 189
SAM  X 501 (-4.3A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.7A)
SAM  X 501 (-3.3A)
0.63A 3aiaA-3ai9X:
37.9
3aiaB-3ai9X:
36.9
3aiaA-3ai9X:
98.58
3aiaB-3ai9X:
98.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 LEU X 169
ARG X 120
ASP X 170
ALA X 174
ASP X 165
None
1.17A 3axtA-3ai9X:
undetectable
3axtA-3ai9X:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 TYR X 135
LEU X 136
GLY X 156
SER X 178
LEU X 184
None
SAM  X 501 (-4.3A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.3A)
0.59A 3axzA-3ai9X:
8.4
3axzA-3ai9X:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 10 LEU X 136
ILE X 155
GLY X 156
GLY X 160
SER X 180
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 (-4.2A)
0.86A 4fakA-3ai9X:
6.5
4fakA-3ai9X:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 LEU X  56
LEU X  73
ILE X 112
GLU X  95
VAL X  36
None
1.11A 4y0qA-3ai9X:
undetectable
4y0qA-3ai9X:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 LEU X 136
ILE X 155
GLY X 156
LEU X 179
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.3A)
0.72A 5nfjA-3ai9X:
7.4
5nfjA-3ai9X:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 9 LEU X 136
ILE X 155
GLY X 156
GLY X 160
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 (-4.3A)
0.77A 5o96A-3ai9X:
10.9
5o96B-3ai9X:
11.1
5o96A-3ai9X:
19.53
5o96B-3ai9X:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 9 LEU X 136
ILE X 155
GLY X 156
LEU X 179
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.3A)
0.62A 5o96A-3ai9X:
10.9
5o96B-3ai9X:
11.1
5o96A-3ai9X:
19.53
5o96B-3ai9X:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 LEU X 136
ILE X 155
GLY X 156
GLY X 160
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 (-4.3A)
0.65A 5twjA-3ai9X:
7.2
5twjA-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
7 / 12 LEU X 136
ILE X 155
GLY X 156
SER X 178
LEU X 179
SER X 180
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
0.51A 5twjA-3ai9X:
7.2
5twjA-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 10 LEU X 136
ILE X 155
GLY X 156
GLY X 160
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 (-4.3A)
0.63A 5twjB-3ai9X:
7.3
5twjB-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 10 LEU X 136
ILE X 155
GLY X 156
LEU X 179
SER X 180
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
0.54A 5twjB-3ai9X:
7.3
5twjB-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 10 LEU X 136
ILE X 155
GLY X 156
SER X 180
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
0.41A 5twjB-3ai9X:
7.3
5twjB-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
6 / 12 LEU X 136
ILE X 155
GLY X 156
SER X 178
LEU X 179
SER X 180
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
0.51A 5twjC-3ai9X:
7.2
5twjC-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
6 / 12 LEU X 136
ILE X 155
GLY X 156
SER X 178
SER X 180
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
0.44A 5twjC-3ai9X:
7.2
5twjC-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
7 / 11 LEU X 136
ILE X 155
GLY X 156
GLY X 160
LEU X 179
SER X 180
LEU X 184
SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
0.72A 5twjD-3ai9X:
7.2
5twjD-3ai9X:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococc
us
jannaschii)
5 / 12 TYR X 135
LEU X 136
GLY X 156
SER X 178
LEU X 184
None
SAM  X 501 (-4.3A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.3A)
0.69A 5wyqB-3ai9X:
4.3
5wyqB-3ai9X:
21.80