SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3aih PROTEIN OS-9
(Homo
sapiens) 		3 / 3 ARG A 226
GLY A 204
ASP A 205
 None
 0.57A 1kf6A-3aihA:
undetectable
1kf6B-3aihA:
undetectable		 1kf6A-3aihA:
11.66
1kf6B-3aihA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3aih PROTEIN OS-9
(Homo
sapiens) 		5 / 12 GLY A 178
GLY A 176
TYR A 175
LEU A 112
THR A 119
 None
 1.12A 1p91B-3aihA:
undetectable		 1p91B-3aihA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3aih PROTEIN OS-9
(Homo
sapiens) 		4 / 8 THR A 224
PRO A 225
LEU A 111
SER A 203
 None
 1.07A 4qknA-3aihA:
undetectable		 4qknA-3aihA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3aih PROTEIN OS-9
(Homo
sapiens) 		5 / 12 ASP A 205
ARG A 226
PHE A 122
LEU A 111
ILE A 207
 None
 1.25A 5b8iC-3aihA:
undetectable		 5b8iC-3aihA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3aih PROTEIN OS-9
(Homo
sapiens) 		4 / 8 TRP A 118
THR A 114
TYR A 120
GLN A 129
 MAN  A 301 (-3.8A)
None
None
None
 1.31A 5tzoB-3aihA:
undetectable		 5tzoB-3aihA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3aih PROTEIN OS-9
(Homo
sapiens) 		4 / 8 TRP A 118
THR A 114
TYR A 120
GLN A 129
 MAN  A 301 (-3.8A)
None
None
None
 1.35A 5tzoC-3aihA:
undetectable		 5tzoC-3aihA:
16.58