SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 VAL A 166
ARG A 171
PHE A 317
VAL A 290
VAL A 287
 None
 1.08A 1fe2A-3aiiA:
undetectable		 1fe2A-3aiiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 440
ASP A 462
ARG A 533
GLU A 532
ARG A 403
 None
 1.28A 1l7fA-3aiiA:
undetectable		 1l7fA-3aiiA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 440
ASP A 462
ARG A 533
GLU A 532
ARG A 403
 None
 1.26A 1l7gA-3aiiA:
undetectable		 1l7gA-3aiiA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 SER A 510
PHE A 406
VAL A 512
VAL A 529
ALA A 537
 None
 1.15A 1q23H-3aiiA:
undetectable
1q23I-3aiiA:
undetectable		 1q23H-3aiiA:
16.57
1q23I-3aiiA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 134
THR A 288
VAL A 287
 None
 0.96A 2qakA-3aiiA:
undetectable		 2qakA-3aiiA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 133
LEU A 131
ILE A 135
ARG A 134
 None
ACY  A 601 (-3.9A)
None
None
 1.11A 2rlfB-3aiiA:
undetectable
2rlfC-3aiiA:
undetectable		 2rlfB-3aiiA:
6.39
2rlfC-3aiiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 LEU A 133
ARG A 356
LEU A 109
ALA A 153
 None
EDO  A 602 ( 4.4A)
None
EDO  A 602 ( 4.7A)
 0.98A 3b9mA-3aiiA:
undetectable		 3b9mA-3aiiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 531
ALA A 537
ALA A 520
GLY A 545
ILE A 505
 None
 1.05A 3c6gA-3aiiA:
undetectable		 3c6gA-3aiiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LEU A  99
LEU A 131
ARG A 125
 None
ACY  A 601 (-3.9A)
None
 0.59A 3hcnB-3aiiA:
2.3		 3hcnB-3aiiA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 PRO A 449
VAL A 446
LEU A 413
LEU A 473
ILE A 491
 None
 1.16A 3u5kB-3aiiA:
undetectable		 3u5kB-3aiiA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLN A 303
ALA A 279
ILE A 132
GLU A 164
VAL A 287
 None
 1.17A 4azwA-3aiiA:
undetectable		 4azwA-3aiiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 440
ASP A 462
ARG A 533
GLU A 532
ARG A 403
 None
 1.29A 4mwvA-3aiiA:
undetectable		 4mwvA-3aiiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A 143
LEU A 133
ILE A 135
ILE A 167
LEU A 109
 None
 0.90A 4y0pA-3aiiA:
undetectable		 4y0pA-3aiiA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PHE A 405
LEU A 448
PRO A 449
ARG A 438
 None
 1.30A 4yv5B-3aiiA:
undetectable		 4yv5B-3aiiA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PHE A 405
LEU A 448
PRO A 449
ARG A 438
 None
 1.30A 4yv5A-3aiiA:
undetectable		 4yv5A-3aiiA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A 449
VAL A 446
VAL A 415
ILE A 491
 None
 0.81A 5pbeA-3aiiA:
undetectable		 5pbeA-3aiiA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3aii GLUTAMYL-TRNA
SYNTHETASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 ILE A 151
LEU A 158
HIS A 110
ALA A 114
 None
 1.00A 6ck2C-3aiiA:
undetectable
6ck2D-3aiiA:
undetectable		 6ck2C-3aiiA:
2.47
6ck2D-3aiiA:
4.43