SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		5 / 10 PHE A 242
VAL A 211
VAL A  48
ILE A  35
LEU A  16
 None
 1.27A 1fe2A-3aizA:
undetectable		 1fe2A-3aizA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A 205
VAL A 208
VAL A 218
VAL A 232
 None
 0.82A 1iwiA-3aizA:
undetectable		 1iwiA-3aizA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		3 / 3 ASP C 144
PHE C 139
VAL C 202
 None
 0.76A 1kijB-3aizC:
undetectable		 1kijB-3aizC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A 205
VAL A 208
VAL A 218
VAL A 232
 None
 0.81A 1t86A-3aizA:
undetectable		 1t86A-3aizA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  13
THR A 107
THR A 109
SER A 111
 None
 1.10A 1tv8B-3aizA:
undetectable		 1tv8B-3aizA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 110
ARG A 103
ILE A  78
 SO4  A 249 ( 4.6A)
SO4  A 249 (-3.2A)
None
 0.76A 1uobA-3aizA:
undetectable		 1uobA-3aizA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 4 LEU A  19
PRO A  53
ILE A 241
LEU A 240
 None
 1.13A 1ya4C-3aizA:
undetectable		 1ya4C-3aizA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 8 SER C 188
LEU C 165
LEU C 225
LEU C 227
 None
 1.02A 2bfpA-3aizC:
undetectable		 2bfpA-3aizC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 8 SER C 188
LEU C 165
LEU C 225
LEU C 227
 None
 0.99A 2bfpB-3aizC:
undetectable		 2bfpB-3aizC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 103
THR A 101
VAL A 100
LEU A  91
 SO4  A 249 (-3.2A)
SO4  A 249 ( 4.1A)
None
None
 1.05A 2e1qC-3aizA:
undetectable		 2e1qC-3aizA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A 205
VAL A 208
VAL A 218
VAL A 232
 None
 0.79A 2z97A-3aizA:
undetectable		 2z97A-3aizA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A 205
VAL A 208
VAL A 218
VAL A 232
 None
 0.80A 2zujA-3aizA:
undetectable		 2zujA-3aizA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 12 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
 None
 1.11A 3a50A-3aizC:
undetectable		 3a50A-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 11 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
 None
 1.12A 3a50C-3aizC:
undetectable		 3a50C-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 12 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
 None
 1.10A 3a50E-3aizC:
undetectable		 3a50E-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 11 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
 None
 1.08A 3a51A-3aizC:
undetectable		 3a51A-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		5 / 12 THR A  41
LEU A  40
ILE A 244
VAL A 130
PRO A 128
 None
 1.19A 3a51B-3aizA:
undetectable		 3a51B-3aizA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		5 / 12 THR A  41
LEU A  40
ILE A 244
VAL A 130
PRO A 128
 None
 1.13A 3a51C-3aizA:
undetectable		 3a51C-3aizA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 12 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
 None
 1.10A 3a51D-3aizC:
undetectable		 3a51D-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A 103
THR A 101
VAL A 100
LEU A  91
 SO4  A 249 (-3.2A)
SO4  A 249 ( 4.1A)
None
None
 1.02A 3ax7A-3aizA:
undetectable		 3ax7A-3aizA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 6 THR C 138
PHE C 139
LEU C 185
LEU C 178
 None
 1.03A 3bgdA-3aizC:
undetectable		 3bgdA-3aizC:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 10 LEU C 178
ALA C 132
ILE C 217
LEU C 227
PHE C 156
 None
 1.04A 3fl9A-3aizC:
undetectable		 3fl9A-3aizC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 10 LEU C 178
ALA C 132
ILE C 217
LEU C 227
PHE C 156
 None
 1.02A 3fl9F-3aizC:
undetectable		 3fl9F-3aizC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 12 LEU C 231
ILE C  49
LEU C  18
PHE C 239
THR C 136
 None
 1.04A 3fl9G-3aizC:
undetectable		 3fl9G-3aizC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 12 LEU C  34
ILE C  36
PHE C  11
ALA C 237
LEU C  18
 None
 0.99A 3gwvA-3aizC:
undetectable		 3gwvA-3aizC:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 7 ARG A 103
THR A 101
VAL A 100
LEU A  91
 SO4  A 249 (-3.2A)
SO4  A 249 ( 4.1A)
None
None
 0.98A 3uniA-3aizA:
undetectable		 3uniA-3aizA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  20
PHE A 209
VAL A 211
THR A 170
GLY A 154
 None
 1.26A 4hvcB-3aizA:
undetectable		 4hvcB-3aizA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 6 ILE C 241
ILE C 143
SER C 206
PHE C  21
 None
 0.97A 4m51A-3aizC:
undetectable		 4m51A-3aizC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 149
VAL A 142
ASP A 145
PHE C 109
 None
 1.10A 4nedA-3aizA:
undetectable		 4nedA-3aizA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 8 ILE C 154
PHE C 139
LEU C 165
LEU C 227
 None
 0.84A 4qopC-3aizC:
undetectable		 4qopC-3aizC:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		6 / 12 LEU C 163
ILE C 176
ILE C 217
ALA C 134
ILE C 143
PHE C 139
 None
 1.41A 4rp8C-3aizC:
undetectable		 4rp8C-3aizC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A 238
GLN A 239
SER A 236
SER A 215
 None
 1.00A 4wrzA-3aizA:
undetectable		 4wrzA-3aizA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A 238
GLN A 239
SER A 236
SER A 215
 None
 0.97A 4ws1A-3aizA:
undetectable		 4ws1A-3aizA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 7 ILE C 119
ILE C  25
ILE C  49
LEU C  27
 None
 0.81A 5fukA-3aizC:
undetectable
5fukB-3aizC:
undetectable		 5fukA-3aizC:
21.17
5fukB-3aizC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 12 VAL C  81
ASP C  85
SER C  12
PHE C  74
LEU C  89
 None
 1.46A 5m54B-3aizC:
undetectable		 5m54B-3aizC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		5 / 12 ALA A 198
LEU A 205
VAL A 166
TYR C 105
ASP A 149
 None
 1.46A 5vlmD-3aizA:
undetectable		 5vlmD-3aizA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 4 PHE C  15
LEU C 101
LEU C  89
VAL C  77
 None
 1.20A 5xxiA-3aizC:
undetectable		 5xxiA-3aizC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		5 / 11 ILE C  14
LEU C  78
PHE C  15
LEU C  27
TYR C  55
 None
 1.07A 5z6mA-3aizC:
undetectable		 5z6mA-3aizC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 3aiz DNA POLYMERASE
SLIDING CLAMP B
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A 237
ASP A  11
ILE A 214
 None
 0.49A 6dgxB-3aizA:
undetectable		 6dgxB-3aizA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 7 ASN C 230
GLY C  54
ALA C  53
LEU C  50
 None
 0.81A 6dwnB-3aizC:
undetectable		 6dwnB-3aizC:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3aiz DNA POLYMERASE
SLIDING CLAMP C
(Sulfurisphaera
tokodaii) 		4 / 6 LEU C 163
TYR C 164
PHE C 130
GLY C 160
 None
 1.05A 6hd4B-3aizC:
undetectable		 6hd4B-3aizC:
18.28