SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 206
THR A 261
ASP A 209
ASP A 184
GLY A 253
 None
 1.20A 1xwfB-3ajaA:
5.2		 1xwfB-3ajaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 271
LEU A 270
ALA A 208
GLY A 266
SER A 267
 None
 1.01A 2a58A-3ajaA:
4.5
2a58B-3ajaA:
4.5		 2a58A-3ajaA:
21.16
2a58B-3ajaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 271
LEU A 270
ALA A 208
GLY A 266
SER A 267
 None
 1.00A 2a58B-3ajaA:
4.5
2a58C-3ajaA:
5.1		 2a58B-3ajaA:
21.16
2a58C-3ajaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 271
LEU A 270
ALA A 208
GLY A 266
SER A 267
 None
 1.02A 2a58D-3ajaA:
4.8
2a58E-3ajaA:
4.8		 2a58D-3ajaA:
21.16
2a58E-3ajaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 288
ALA A 241
SER A 142
LEU A 244
ASP A 145
 None
 1.29A 2c12F-3ajaA:
undetectable		 2c12F-3ajaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A 247
MET A 246
THR A 232
ALA A 229
VAL A 180
 None
 1.46A 2cojA-3ajaA:
undetectable
2cojB-3ajaA:
undetectable		 2cojA-3ajaA:
22.98
2cojB-3ajaA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 211
MET A 246
THR A 245
LEU A 244
 None
 1.35A 3ag1J-3ajaA:
undetectable		 3ag1J-3ajaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 125
ILE A  81
ILE A 181
THR A 153
 None
 0.86A 3deuA-3ajaA:
undetectable		 3deuA-3ajaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TYR A 127
TYR A 143
GLY A 178
 None
 0.75A 3eteB-3ajaA:
undetectable
3eteD-3ajaA:
2.8
3eteF-3ajaA:
undetectable		 3eteB-3ajaA:
20.87
3eteD-3ajaA:
20.87
3eteF-3ajaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.05A 3keeA-3ajaA:
undetectable		 3keeA-3ajaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.06A 3keeB-3ajaA:
undetectable		 3keeB-3ajaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.04A 3keeC-3ajaA:
undetectable		 3keeC-3ajaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.05A 3keeD-3ajaA:
undetectable		 3keeD-3ajaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 0.98A 3sueA-3ajaA:
undetectable		 3sueA-3ajaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.02A 3sueC-3ajaA:
undetectable		 3sueC-3ajaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.03A 3sueD-3ajaA:
undetectable		 3sueD-3ajaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 0.93A 3sufA-3ajaA:
undetectable		 3sufA-3ajaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 0.93A 3sufB-3ajaA:
undetectable		 3sufB-3ajaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 189
ASP A 188
ILE A 185
VAL A  79
ARG A 164
 None
 0.83A 4ac9B-3ajaA:
4.2
4ac9C-3ajaA:
4.2		 4ac9B-3ajaA:
21.02
4ac9C-3ajaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A 188
ILE A 185
VAL A  79
ARG A 164
 None
 0.87A 4acbB-3ajaA:
4.2
4acbC-3ajaA:
4.2		 4acbB-3ajaA:
21.02
4acbC-3ajaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 8 ARG A 250
GLY A 192
ASP A 197
ASP A 199
THR A 261
 None
 1.43A 4eyrB-3ajaA:
undetectable		 4eyrB-3ajaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 250
GLY A 253
ASP A 184
ARG A 193
 None
 1.22A 4lajA-3ajaA:
undetectable
4lajB-3ajaA:
undetectable		 4lajA-3ajaA:
20.91
4lajB-3ajaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 127
GLY A 174
ILE A 172
SER A 176
ALA A 179
 None
 1.17A 4qtuD-3ajaA:
undetectable		 4qtuD-3ajaA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ILE A 207
MET A 214
ASP A 269
 None
 0.71A 5h2uA-3ajaA:
undetectable		 5h2uA-3ajaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 172
ILE A 189
VAL A 204
THR A 261
ASN A 259
 None
 1.25A 5lg3F-3ajaA:
undetectable		 5lg3F-3ajaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 172
ILE A 189
VAL A 204
THR A 261
ASN A 259
 None
 1.28A 5lg3G-3ajaA:
undetectable		 5lg3G-3ajaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 160
PRO A 126
GLU A 149
THR A 153
 None
 1.42A 5uxcA-3ajaA:
undetectable		 5uxcA-3ajaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 126
GLU A 149
ARG A 152
THR A 153
 None
 1.15A 5uxcA-3ajaA:
undetectable		 5uxcA-3ajaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ARG A 193
MET A 158
VAL A  79
GLY A 183
ILE A 185
 None
 1.12A 5vooE-3ajaA:
undetectable		 5vooE-3ajaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3aja PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 211
MET A 246
THR A 245
LEU A 244
 None
 1.35A 6nknJ-3ajaA:
undetectable		 6nknJ-3ajaA:
18.05