SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A  13
ILE A 170
TYR A  38
GLY A  39
 None
None
None
THR  A 353 (-3.3A)
 1.12A 1maaB-3ajeA:
undetectable
1maaD-3ajeA:
undetectable		 1maaB-3ajeA:
20.72
1maaD-3ajeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A 246
LEU A 245
LEU A 305
GLY A 313
LEU A 259
 None
 1.12A 1pxxA-3ajeA:
undetectable		 1pxxA-3ajeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A  38
ILE A 171
GLY A 173
LEU A  10
 None
 0.89A 2vctA-3ajeA:
undetectable		 2vctA-3ajeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A  38
ILE A 171
GLY A 173
LEU A  10
 None
 0.87A 2vctC-3ajeA:
undetectable		 2vctC-3ajeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  38
ILE A 171
GLY A 173
LEU A  10
 None
 0.92A 2vctD-3ajeA:
undetectable		 2vctD-3ajeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 187
ILE A  66
THR A 183
SER A 182
ILE A 185
 None
ANP  A 354 ( 3.4A)
None
THR  A 353 (-2.6A)
None
 1.45A 3hbbB-3ajeA:
3.3		 3hbbB-3ajeA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A 245
GLU A 247
SER A 335
PHE A 337
 None
 1.18A 3i9jB-3ajeA:
undetectable		 3i9jB-3ajeA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 5 PHE A 302
LEU A 245
GLY A 317
VAL A 294
 None
 0.89A 3wrkA-3ajeA:
undetectable		 3wrkA-3ajeA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 5 PHE A 302
LEU A 245
GLY A 317
VAL A 294
 None
 0.90A 3wrkD-3ajeA:
undetectable		 3wrkD-3ajeA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		4 / 6 PHE A 100
ALA A  90
GLY A  96
PRO A  97
 None
 1.04A 4dubA-3ajeA:
undetectable		 4dubA-3ajeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A 294
ALA A 295
VAL A 180
PHE A 318
GLY A 324
 None
 1.18A 4mm4B-3ajeA:
undetectable		 4mm4B-3ajeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.09A 4mm5A-3ajeA:
undetectable		 4mm5A-3ajeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.01A 4mm8A-3ajeA:
undetectable		 4mm8A-3ajeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.09A 4mmbA-3ajeA:
undetectable		 4mmbA-3ajeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.09A 4mmdA-3ajeA:
undetectable		 4mmdA-3ajeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.16A 4mmdB-3ajeA:
undetectable		 4mmdB-3ajeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 0.99A 4mmeB-3ajeA:
undetectable		 4mmeB-3ajeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.04A 4mmfA-3ajeA:
undetectable		 4mmfA-3ajeA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 294
ALA A 295
GLY A 317
PHE A 318
GLY A 324
 None
 1.00A 4mmfB-3ajeA:
undetectable		 4mmfB-3ajeA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A 306
LEU A 305
PHE A 302
 None
 0.66A 4pthA-3ajeA:
3.6		 4pthA-3ajeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A 170
LEU A 132
LEU A  40
GLY A  39
ALA A  42
 None
None
None
THR  A 353 (-3.3A)
None
 1.21A 5fctA-3ajeA:
undetectable		 5fctA-3ajeA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A  47
ASP A  46
ASN A  26
 None
 0.57A 5jglA-3ajeA:
undetectable		 5jglA-3ajeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 ALA A  31
ILE A 171
ILE A 140
ALA A 129
LEU A 132
 None
 1.11A 5mvmA-3ajeA:
undetectable
5mvmE-3ajeA:
undetectable		 5mvmA-3ajeA:
11.61
5mvmE-3ajeA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 ILE A 171
ALA A  20
ILE A  17
ILE A 133
ALA A 129
 None
 1.12A 5mvmA-3ajeA:
undetectable
5mvmE-3ajeA:
undetectable		 5mvmA-3ajeA:
11.61
5mvmE-3ajeA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 9 THR A 105
ARG A 107
PRO A 139
PHE A  45
VAL A  67
 None
 1.09A 6ef6A-3ajeA:
undetectable		 6ef6A-3ajeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A 170
LEU A 132
LEU A  40
GLY A  39
ALA A  42
 None
None
None
THR  A 353 (-3.3A)
None
 1.19A 6r2eF-3ajeA:
undetectable		 6r2eF-3ajeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 170
LEU A 132
LEU A  40
GLY A  39
ALA A  42
 None
None
None
THR  A 353 (-3.3A)
None
 1.18A 6r2eH-3ajeA:
undetectable		 6r2eH-3ajeA:
21.12