SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ajy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 8 VAL A  34
VAL A 131
LEU A 133
VAL A  19
 None
 0.74A 2zujA-3ajyA:
undetectable		 2zujA-3ajyA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 6 HIS A  44
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 136 (-3.9A)
BGC  A 135 ( 2.9A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.5A)
BGC  A 135 ( 2.6A)
 0.36A 3galA-3ajyA:
17.4		 3galA-3ajyA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 6 HIS A  44
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 136 (-3.9A)
BGC  A 135 ( 2.9A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.5A)
BGC  A 135 ( 2.6A)
 0.44A 3galB-3ajyA:
17.1		 3galB-3ajyA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 12 LEU A  43
LEU A  41
ILE A  98
ILE A  87
LEU A  17
 None
 1.20A 4j24B-3ajyA:
undetectable		 4j24B-3ajyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 5 TYR A  97
ILE A  98
ASN A 110
ILE A  89
 None
 1.05A 4jtpA-3ajyA:
undetectable		 4jtpA-3ajyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 6 LEU A 101
LEU A 100
GLU A  99
ILE A  87
 None
 0.77A 4ww7A-3ajyA:
undetectable		 4ww7A-3ajyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		3 / 3 ASN A  33
SER A  31
ARG A  29
 None
None
GAL  A 136 (-2.9A)
 0.78A 5b2qA-3ajyA:
undetectable		 5b2qA-3ajyA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		6 / 7 HIS A  44
ARG A  48
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 136 (-3.9A)
BGC  A 135 ( 2.9A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.5A)
BGC  A 135 ( 2.6A)
BGC  A 135 (-4.1A)
 0.76A 6b8kA-3ajyA:
17.7		 6b8kA-3ajyA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 8 HIS A  44
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 GAL  A 136 (-3.9A)
BGC  A 135 ( 2.9A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.5A)
BGC  A 135 ( 2.6A)
 0.48A 6b94A-3ajyA:
22.0		 6b94A-3ajyA:
43.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 8 HIS A  44
ARG A  48
TRP A  68
GLU A  71
ARG A  73
 GAL  A 136 (-3.9A)
BGC  A 135 ( 2.9A)
GAL  A 136 (-3.5A)
BGC  A 135 ( 2.6A)
BGC  A 135 (-4.1A)
 0.84A 6b94A-3ajyA:
22.0		 6b94A-3ajyA:
43.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 3ajy ANCESTRAL CONGERIN
CON-ANC
(-) 		7 / 10 HIS A  44
ARG A  48
ASP A  54
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 GAL  A 136 (-3.9A)
BGC  A 135 ( 2.9A)
None
GAL  A 136 (-3.7A)
GAL  A 136 (-3.5A)
BGC  A 135 ( 2.6A)
BGC  A 135 (-4.1A)
 0.81A 6b94A-3ajyA:
22.0
6b94B-3ajyA:
21.9		 6b94A-3ajyA:
43.21
6b94B-3ajyA:
43.21