SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ajz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 8 PHE A 106
ALA A  40
PHE A 115
ILE A  39
 None
 0.99A 1gm7A-3ajzA:
undetectable
1gm7B-3ajzA:
undetectable		 1gm7A-3ajzA:
22.68
1gm7B-3ajzA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 12 ASN A  74
SER A  72
LEU A  58
ILE A  87
LEU A  41
 None
 1.25A 1lhuA-3ajzA:
8.8		 1lhuA-3ajzA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 12 LEU A  11
ILE A  91
HIS A 110
GLY A 111
GLY A  33
 None
 1.07A 1zz1C-3ajzA:
undetectable		 1zz1C-3ajzA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 6 SER A  35
SER A  38
ASP A  63
ASP A  37
 None
 1.18A 2j2pE-3ajzA:
undetectable
2j2pF-3ajzA:
undetectable		 2j2pE-3ajzA:
20.09
2j2pF-3ajzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		3 / 3 ASP A  37
THR A   8
GLU A  34
 None
 0.65A 2zifB-3ajzA:
undetectable		 2zifB-3ajzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 8 VAL A  32
VAL A 129
LEU A 131
VAL A  17
 None
 0.73A 2zujA-3ajzA:
undetectable		 2zujA-3ajzA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 6 HIS A  42
ARG A  46
ASN A  59
TRP A  66
GLU A  69
 GAL  A 133 (-4.0A)
BGC  A 134 ( 2.8A)
GAL  A 133 (-3.8A)
GAL  A 133 (-3.7A)
BGC  A 134 ( 2.8A)
 0.19A 3galA-3ajzA:
19.7		 3galA-3ajzA:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 6 HIS A  42
ARG A  46
ASN A  59
TRP A  66
GLU A  69
 GAL  A 133 (-4.0A)
BGC  A 134 ( 2.8A)
GAL  A 133 (-3.8A)
GAL  A 133 (-3.7A)
BGC  A 134 ( 2.8A)
 0.24A 3galB-3ajzA:
19.2		 3galB-3ajzA:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 10 VAL A  17
PHE A  83
ALA A 121
ILE A  39
VAL A  32
 None
 1.04A 3me6A-3ajzA:
undetectable		 3me6A-3ajzA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 10 VAL A  17
PHE A  83
ILE A 118
ALA A 121
ILE A  39
 None
 1.09A 3me6A-3ajzA:
undetectable		 3me6A-3ajzA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 5 TYR A  95
ILE A  96
ASN A 108
ILE A  87
 None
 1.05A 4jtpA-3ajzA:
undetectable		 4jtpA-3ajzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 6 TRP A  66
ILE A  39
ILE A  85
VAL A  17
 GAL  A 133 (-3.7A)
None
None
None
 0.93A 4zj8A-3ajzA:
undetectable		 4zj8A-3ajzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		3 / 3 ASN A  31
SER A  29
ARG A  27
 None
None
GAL  A 133 (-2.9A)
 0.95A 5b2qA-3ajzA:
undetectable		 5b2qA-3ajzA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		4 / 7 ASN A  31
HIS A  42
ASP A  64
GLY A  65
 None
GAL  A 133 (-4.0A)
None
None
 1.07A 5x7pA-3ajzA:
undetectable		 5x7pA-3ajzA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 9 SER A  29
PHE A  83
SER A  23
GLY A  80
THR A 127
 None
 1.20A 6awpA-3ajzA:
undetectable		 6awpA-3ajzA:
13.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		6 / 7 HIS A  42
ARG A  46
ASN A  59
TRP A  66
GLU A  69
ARG A  71
 GAL  A 133 (-4.0A)
BGC  A 134 ( 2.8A)
GAL  A 133 (-3.8A)
GAL  A 133 (-3.7A)
BGC  A 134 ( 2.8A)
BGC  A 134 ( 4.4A)
 0.67A 6b8kA-3ajzA:
19.7		 6b8kA-3ajzA:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 8 HIS A  42
ARG A  46
ASN A  59
TRP A  66
GLU A  69
 GAL  A 133 (-4.0A)
BGC  A 134 ( 2.8A)
GAL  A 133 (-3.8A)
GAL  A 133 (-3.7A)
BGC  A 134 ( 2.8A)
 0.39A 6b94A-3ajzA:
24.5		 6b94A-3ajzA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		5 / 8 HIS A  42
ARG A  46
TRP A  66
GLU A  69
ARG A  71
 GAL  A 133 (-4.0A)
BGC  A 134 ( 2.8A)
GAL  A 133 (-3.7A)
BGC  A 134 ( 2.8A)
BGC  A 134 ( 4.4A)
 0.75A 6b94A-3ajzA:
24.5		 6b94A-3ajzA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 3ajz ANCESTRAL CONGERIN
CON-ANC
(-) 		7 / 10 HIS A  42
ARG A  46
ASP A  52
ASN A  59
TRP A  66
GLU A  69
ARG A  71
 GAL  A 133 (-4.0A)
BGC  A 134 ( 2.8A)
None
GAL  A 133 (-3.8A)
GAL  A 133 (-3.7A)
BGC  A 134 ( 2.8A)
BGC  A 134 ( 4.4A)
 0.74A 6b94A-3ajzA:
24.5
6b94B-3ajzA:
24.4		 6b94A-3ajzA:
35.63
6b94B-3ajzA:
35.63