SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ak1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		3 / 3 VAL A 152
TRP A 130
TRP A 167
 None
 1.43A 1c4dA-3ak1A:
undetectable
1c4dB-3ak1A:
undetectable		 1c4dA-3ak1A:
5.14
1c4dB-3ak1A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		3 / 3 ALA A 121
VAL A 132
TRP A 130
 None
 0.93A 1gmkC-3ak1A:
undetectable
1gmkD-3ak1A:
undetectable		 1gmkC-3ak1A:
5.14
1gmkD-3ak1A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 5 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 1.00A 1rs7A-3ak1A:
undetectable		 1rs7A-3ak1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 6 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 1.05A 1rs7B-3ak1A:
undetectable		 1rs7B-3ak1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 7 GLY A 129
HIS A  31
HIS A  35
HIS A 150
 None
EDO  A 218 (-3.7A)
EDO  A 219 (-4.2A)
None
 1.19A 3ai8A-3ak1A:
undetectable		 3ai8A-3ak1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 5 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 0.97A 4d33A-3ak1A:
undetectable		 4d33A-3ak1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 5 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 0.99A 4d33B-3ak1A:
undetectable		 4d33B-3ak1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 6 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 0.99A 4d39B-3ak1A:
undetectable		 4d39B-3ak1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		5 / 12 LEU A 199
TRP A 187
PHE A 114
PHE A 118
PHE A 108
 None
 1.34A 4iaqA-3ak1A:
undetectable		 4iaqA-3ak1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		4 / 6 GLY A  75
ILE A  77
TRP A 130
VAL A 147
 None
 1.02A 4kcnA-3ak1A:
undetectable		 4kcnA-3ak1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		5 / 12 ILE A 104
LEU A 133
GLU A 112
PHE A 114
GLY A 110
 None
 1.29A 5il1A-3ak1A:
undetectable		 5il1A-3ak1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3ak1 SUPEROXIDE DISMUTASE
[MN/FE]
(Aeropyrum
pernix) 		5 / 12 ILE A 104
LEU A 133
GLU A 112
PHE A 114
GLY A 110
 None
 1.30A 5k7uA-3ak1A:
undetectable		 5k7uA-3ak1A:
20.08